Candida auris—the growing menace to global health
summary A paradigm shift of candidiasis from Candida albicans to non‐albicans Candida species has fundamentally increased with the advent of C. auris . C. auris, despite being a newly emerged multidrug‐resistant fungal pathogen, is associated with severe invasive infections and outbreaks with high m...
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crwiley:10.1111/myc.12904 2024-09-30T14:26:27+00:00 Candida auris—the growing menace to global health Lone, Shabir A. Ahmad, Aijaz South African Agency for Science and Technology Advancement University of the Witwatersrand, Johannesburg 2019 http://dx.doi.org/10.1111/myc.12904 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmyc.12904 https://onlinelibrary.wiley.com/doi/pdf/10.1111/myc.12904 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/myc.12904 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Mycoses volume 62, issue 8, page 620-637 ISSN 0933-7407 1439-0507 journal-article 2019 crwiley https://doi.org/10.1111/myc.12904 2024-09-17T04:48:21Z summary A paradigm shift of candidiasis from Candida albicans to non‐albicans Candida species has fundamentally increased with the advent of C. auris . C. auris, despite being a newly emerged multidrug‐resistant fungal pathogen, is associated with severe invasive infections and outbreaks with high mortality rates. Initially reported from Japan in 2009, C. auris have now been found in different countries on all the continents except Antarctica. Due to its capability of nosocomial transmission and forming adherent biofilms on clinically important substrates, a high number of related hospital outbreaks have been reported worldwide. As C. auris is a multidrug‐resistant pathogen and is prone to misidentification by available conventional methods, it becomes difficult to detect and manage C. auris infection and also limits the therapeutic options against this deadly pathogen. The emergence of multidrug‐resistant C. auris advocates and amplifies the vigilance of early diagnosis and appropriate treatment of fungal infections. In this review, we discussed the nine‐year‐old history of C. auris —its trends in global emergence, epidemiological relatedness, isolation, mortality, associated risk factors, virulence factors, drug resistance and susceptibility testing, diagnostic challenges, microbiological characteristics, therapeutic options and infection prevention and control associated with this pathogen. Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library Mycoses 62 8 620 637 |
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summary A paradigm shift of candidiasis from Candida albicans to non‐albicans Candida species has fundamentally increased with the advent of C. auris . C. auris, despite being a newly emerged multidrug‐resistant fungal pathogen, is associated with severe invasive infections and outbreaks with high mortality rates. Initially reported from Japan in 2009, C. auris have now been found in different countries on all the continents except Antarctica. Due to its capability of nosocomial transmission and forming adherent biofilms on clinically important substrates, a high number of related hospital outbreaks have been reported worldwide. As C. auris is a multidrug‐resistant pathogen and is prone to misidentification by available conventional methods, it becomes difficult to detect and manage C. auris infection and also limits the therapeutic options against this deadly pathogen. The emergence of multidrug‐resistant C. auris advocates and amplifies the vigilance of early diagnosis and appropriate treatment of fungal infections. In this review, we discussed the nine‐year‐old history of C. auris —its trends in global emergence, epidemiological relatedness, isolation, mortality, associated risk factors, virulence factors, drug resistance and susceptibility testing, diagnostic challenges, microbiological characteristics, therapeutic options and infection prevention and control associated with this pathogen. |
author2 |
South African Agency for Science and Technology Advancement University of the Witwatersrand, Johannesburg |
format |
Article in Journal/Newspaper |
author |
Lone, Shabir A. Ahmad, Aijaz |
spellingShingle |
Lone, Shabir A. Ahmad, Aijaz Candida auris—the growing menace to global health |
author_facet |
Lone, Shabir A. Ahmad, Aijaz |
author_sort |
Lone, Shabir A. |
title |
Candida auris—the growing menace to global health |
title_short |
Candida auris—the growing menace to global health |
title_full |
Candida auris—the growing menace to global health |
title_fullStr |
Candida auris—the growing menace to global health |
title_full_unstemmed |
Candida auris—the growing menace to global health |
title_sort |
candida auris—the growing menace to global health |
publisher |
Wiley |
publishDate |
2019 |
url |
http://dx.doi.org/10.1111/myc.12904 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmyc.12904 https://onlinelibrary.wiley.com/doi/pdf/10.1111/myc.12904 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/myc.12904 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Mycoses volume 62, issue 8, page 620-637 ISSN 0933-7407 1439-0507 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/myc.12904 |
container_title |
Mycoses |
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62 |
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8 |
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620 |
op_container_end_page |
637 |
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1811646787071508480 |