Circulating glutathione concentrations in marine, semiaquatic, and terrestrial mammals
Abstract An important low molecular weight antioxidant in biological systems is glutathione; its efficiency depends on the equilibrium between its reduced ( GSH ) and oxidized ( GSSG ) forms. The oxidized:total glutathione ( GSSG : GSH ‐Eq) ratio can be used as an indicator of oxidative stress. Prev...
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crwiley:10.1111/mms.12391 2024-06-23T07:52:29+00:00 Circulating glutathione concentrations in marine, semiaquatic, and terrestrial mammals García‐Castañeda, Omar Gaxiola‐Robles, Ramón Kanatous, Shane Zenteno‐Savín, Tania Consejo Nacional de Ciencia y Tecnología 2017 http://dx.doi.org/10.1111/mms.12391 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmms.12391 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mms.12391 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Marine Mammal Science volume 33, issue 3, page 738-747 ISSN 0824-0469 1748-7692 journal-article 2017 crwiley https://doi.org/10.1111/mms.12391 2024-06-13T04:22:41Z Abstract An important low molecular weight antioxidant in biological systems is glutathione; its efficiency depends on the equilibrium between its reduced ( GSH ) and oxidized ( GSSG ) forms. The oxidized:total glutathione ( GSSG : GSH ‐Eq) ratio can be used as an indicator of oxidative stress. Previous studies suggest that marine mammals, unlike terrestrial mammals, do not show adverse effects in tissues exposed to ischemia/reperfusion during the peripheral vasoconstriction associated with breath‐hold diving. This is due, in part, to higher antioxidant enzyme activities in marine mammals compared with terrestrial mammals. The objective of this study was to compare circulating glutathione levels among mammals with different diving capacities. Circulating GSH ‐Eq, GSH , and GSSG concentrations in erythrocyte samples from northern elephant seals ( Mirounga angustirostris ), bottlenose dolphins ( Tursiops truncatus ), neotropical otters ( Lontra longicaudis annectens) , domestic pigs ( Sus scrofa ), and humans were quantified using spectrophotometry. Higher GSH ‐Eq and GSH concentrations and a lower GSSG : GSH ‐Eq index were found in erythrocytes from northern elephant seals and bottlenose dolphins as compared to otters, domestic pigs, and humans. Results suggest that marine mammals, independent of their diving capacity, possess a highly developed antioxidant system, including GSH continuous availability of GSH could allow these species to avoid oxidative damage and tolerate ischemia/reperfusion and hypoxia/reoxygenation events associated with diving. Article in Journal/Newspaper Elephant Seals Lontra Wiley Online Library Marine Mammal Science 33 3 738 747 |
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Wiley Online Library |
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English |
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Abstract An important low molecular weight antioxidant in biological systems is glutathione; its efficiency depends on the equilibrium between its reduced ( GSH ) and oxidized ( GSSG ) forms. The oxidized:total glutathione ( GSSG : GSH ‐Eq) ratio can be used as an indicator of oxidative stress. Previous studies suggest that marine mammals, unlike terrestrial mammals, do not show adverse effects in tissues exposed to ischemia/reperfusion during the peripheral vasoconstriction associated with breath‐hold diving. This is due, in part, to higher antioxidant enzyme activities in marine mammals compared with terrestrial mammals. The objective of this study was to compare circulating glutathione levels among mammals with different diving capacities. Circulating GSH ‐Eq, GSH , and GSSG concentrations in erythrocyte samples from northern elephant seals ( Mirounga angustirostris ), bottlenose dolphins ( Tursiops truncatus ), neotropical otters ( Lontra longicaudis annectens) , domestic pigs ( Sus scrofa ), and humans were quantified using spectrophotometry. Higher GSH ‐Eq and GSH concentrations and a lower GSSG : GSH ‐Eq index were found in erythrocytes from northern elephant seals and bottlenose dolphins as compared to otters, domestic pigs, and humans. Results suggest that marine mammals, independent of their diving capacity, possess a highly developed antioxidant system, including GSH continuous availability of GSH could allow these species to avoid oxidative damage and tolerate ischemia/reperfusion and hypoxia/reoxygenation events associated with diving. |
author2 |
Consejo Nacional de Ciencia y Tecnología |
format |
Article in Journal/Newspaper |
author |
García‐Castañeda, Omar Gaxiola‐Robles, Ramón Kanatous, Shane Zenteno‐Savín, Tania |
spellingShingle |
García‐Castañeda, Omar Gaxiola‐Robles, Ramón Kanatous, Shane Zenteno‐Savín, Tania Circulating glutathione concentrations in marine, semiaquatic, and terrestrial mammals |
author_facet |
García‐Castañeda, Omar Gaxiola‐Robles, Ramón Kanatous, Shane Zenteno‐Savín, Tania |
author_sort |
García‐Castañeda, Omar |
title |
Circulating glutathione concentrations in marine, semiaquatic, and terrestrial mammals |
title_short |
Circulating glutathione concentrations in marine, semiaquatic, and terrestrial mammals |
title_full |
Circulating glutathione concentrations in marine, semiaquatic, and terrestrial mammals |
title_fullStr |
Circulating glutathione concentrations in marine, semiaquatic, and terrestrial mammals |
title_full_unstemmed |
Circulating glutathione concentrations in marine, semiaquatic, and terrestrial mammals |
title_sort |
circulating glutathione concentrations in marine, semiaquatic, and terrestrial mammals |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1111/mms.12391 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmms.12391 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mms.12391 |
genre |
Elephant Seals Lontra |
genre_facet |
Elephant Seals Lontra |
op_source |
Marine Mammal Science volume 33, issue 3, page 738-747 ISSN 0824-0469 1748-7692 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/mms.12391 |
container_title |
Marine Mammal Science |
container_volume |
33 |
container_issue |
3 |
container_start_page |
738 |
op_container_end_page |
747 |
_version_ |
1802643798045491200 |