Population genomics of the muskox' resilience in the near absence of genetic variation
Abstract Genomic studies of species threatened by extinction are providing crucial information about evolutionary mechanisms and genetic consequences of population declines and bottlenecks. However, to understand how species avoid the extinction vortex, insights can be drawn by studying species that...
Published in: | Molecular Ecology |
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Online Access: | http://dx.doi.org/10.1111/mec.17205 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.17205 |
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crwiley:10.1111/mec.17205 2024-05-19T07:44:05+00:00 Population genomics of the muskox' resilience in the near absence of genetic variation Pečnerová, Patrícia Lord, Edana Garcia‐Erill, Genís Hanghøj, Kristian Rasmussen, Malthe Sebro Meisner, Jonas Liu, Xiaodong van der Valk, Tom Santander, Cindy G. Quinn, Liam Lin, Long Liu, Shanlin Carøe, Christian Dalerum, Fredrik Götherström, Anders Måsviken, Johannes Vartanyan, Sergey Raundrup, Katrine Al‐Chaer, Amal Rasmussen, Linett Hvilsom, Christina Heide‐Jørgensen, Mads Peter Sinding, Mikkel‐Holger S. Aastrup, Peter Van Coeverden de Groot, Peter J. Schmidt, Niels Martin Albrechtsen, Anders Dalén, Love Heller, Rasmus Moltke, Ida Siegismund, Hans Redlef Carlsbergfondet Danmarks Frie Forskningsfond 2023 http://dx.doi.org/10.1111/mec.17205 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.17205 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Molecular Ecology volume 33, issue 2 ISSN 0962-1083 1365-294X Genetics Ecology, Evolution, Behavior and Systematics journal-article 2023 crwiley https://doi.org/10.1111/mec.17205 2024-04-22T07:35:18Z Abstract Genomic studies of species threatened by extinction are providing crucial information about evolutionary mechanisms and genetic consequences of population declines and bottlenecks. However, to understand how species avoid the extinction vortex, insights can be drawn by studying species that thrive despite past declines. Here, we studied the population genomics of the muskox ( Ovibos moschatus ), an Ice Age relict that was at the brink of extinction for thousands of years at the end of the Pleistocene yet appears to be thriving today. We analysed 108 whole genomes, including present‐day individuals representing the current native range of both muskox subspecies, the white‐faced and the barren‐ground muskox ( O. moschatus wardi and O. moschatus moschatus ) and a ~21,000‐year‐old ancient individual from Siberia. We found that the muskox' demographic history was profoundly shaped by past climate changes and post‐glacial re‐colonizations. In particular, the white‐faced muskox has the lowest genome‐wide heterozygosity recorded in an ungulate. Yet, there is no evidence of inbreeding depression in native muskox populations. We hypothesize that this can be explained by the effect of long‐term gradual population declines that allowed for purging of strongly deleterious mutations. This study provides insights into how species with a history of population bottlenecks, small population sizes and low genetic diversity survive against all odds. Article in Journal/Newspaper muskox ovibos moschatus Siberia Wiley Online Library Molecular Ecology 33 2 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
topic |
Genetics Ecology, Evolution, Behavior and Systematics |
spellingShingle |
Genetics Ecology, Evolution, Behavior and Systematics Pečnerová, Patrícia Lord, Edana Garcia‐Erill, Genís Hanghøj, Kristian Rasmussen, Malthe Sebro Meisner, Jonas Liu, Xiaodong van der Valk, Tom Santander, Cindy G. Quinn, Liam Lin, Long Liu, Shanlin Carøe, Christian Dalerum, Fredrik Götherström, Anders Måsviken, Johannes Vartanyan, Sergey Raundrup, Katrine Al‐Chaer, Amal Rasmussen, Linett Hvilsom, Christina Heide‐Jørgensen, Mads Peter Sinding, Mikkel‐Holger S. Aastrup, Peter Van Coeverden de Groot, Peter J. Schmidt, Niels Martin Albrechtsen, Anders Dalén, Love Heller, Rasmus Moltke, Ida Siegismund, Hans Redlef Population genomics of the muskox' resilience in the near absence of genetic variation |
topic_facet |
Genetics Ecology, Evolution, Behavior and Systematics |
description |
Abstract Genomic studies of species threatened by extinction are providing crucial information about evolutionary mechanisms and genetic consequences of population declines and bottlenecks. However, to understand how species avoid the extinction vortex, insights can be drawn by studying species that thrive despite past declines. Here, we studied the population genomics of the muskox ( Ovibos moschatus ), an Ice Age relict that was at the brink of extinction for thousands of years at the end of the Pleistocene yet appears to be thriving today. We analysed 108 whole genomes, including present‐day individuals representing the current native range of both muskox subspecies, the white‐faced and the barren‐ground muskox ( O. moschatus wardi and O. moschatus moschatus ) and a ~21,000‐year‐old ancient individual from Siberia. We found that the muskox' demographic history was profoundly shaped by past climate changes and post‐glacial re‐colonizations. In particular, the white‐faced muskox has the lowest genome‐wide heterozygosity recorded in an ungulate. Yet, there is no evidence of inbreeding depression in native muskox populations. We hypothesize that this can be explained by the effect of long‐term gradual population declines that allowed for purging of strongly deleterious mutations. This study provides insights into how species with a history of population bottlenecks, small population sizes and low genetic diversity survive against all odds. |
author2 |
Carlsbergfondet Danmarks Frie Forskningsfond |
format |
Article in Journal/Newspaper |
author |
Pečnerová, Patrícia Lord, Edana Garcia‐Erill, Genís Hanghøj, Kristian Rasmussen, Malthe Sebro Meisner, Jonas Liu, Xiaodong van der Valk, Tom Santander, Cindy G. Quinn, Liam Lin, Long Liu, Shanlin Carøe, Christian Dalerum, Fredrik Götherström, Anders Måsviken, Johannes Vartanyan, Sergey Raundrup, Katrine Al‐Chaer, Amal Rasmussen, Linett Hvilsom, Christina Heide‐Jørgensen, Mads Peter Sinding, Mikkel‐Holger S. Aastrup, Peter Van Coeverden de Groot, Peter J. Schmidt, Niels Martin Albrechtsen, Anders Dalén, Love Heller, Rasmus Moltke, Ida Siegismund, Hans Redlef |
author_facet |
Pečnerová, Patrícia Lord, Edana Garcia‐Erill, Genís Hanghøj, Kristian Rasmussen, Malthe Sebro Meisner, Jonas Liu, Xiaodong van der Valk, Tom Santander, Cindy G. Quinn, Liam Lin, Long Liu, Shanlin Carøe, Christian Dalerum, Fredrik Götherström, Anders Måsviken, Johannes Vartanyan, Sergey Raundrup, Katrine Al‐Chaer, Amal Rasmussen, Linett Hvilsom, Christina Heide‐Jørgensen, Mads Peter Sinding, Mikkel‐Holger S. Aastrup, Peter Van Coeverden de Groot, Peter J. Schmidt, Niels Martin Albrechtsen, Anders Dalén, Love Heller, Rasmus Moltke, Ida Siegismund, Hans Redlef |
author_sort |
Pečnerová, Patrícia |
title |
Population genomics of the muskox' resilience in the near absence of genetic variation |
title_short |
Population genomics of the muskox' resilience in the near absence of genetic variation |
title_full |
Population genomics of the muskox' resilience in the near absence of genetic variation |
title_fullStr |
Population genomics of the muskox' resilience in the near absence of genetic variation |
title_full_unstemmed |
Population genomics of the muskox' resilience in the near absence of genetic variation |
title_sort |
population genomics of the muskox' resilience in the near absence of genetic variation |
publisher |
Wiley |
publishDate |
2023 |
url |
http://dx.doi.org/10.1111/mec.17205 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.17205 |
genre |
muskox ovibos moschatus Siberia |
genre_facet |
muskox ovibos moschatus Siberia |
op_source |
Molecular Ecology volume 33, issue 2 ISSN 0962-1083 1365-294X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/mec.17205 |
container_title |
Molecular Ecology |
container_volume |
33 |
container_issue |
2 |
_version_ |
1799483843007217664 |