Genetic features of bivalve transmissible neoplasia in blue mussels from the Kola Bay (Barents Sea) suggest a recent trans‐Arctic migration of the cancer lineages
Abstract Ecology and biogeography of bivalve transmissible neoplasia (BTN) are underexplored due to its recent discovery and a challenging diagnostics. Blue mussels harbour two evolutionary lineages of BTN, Mtr BTN1 and Mtr BTN2, both derived from Mytilus trossulus . Mtr BTN1 has been found only in...
Published in: | Molecular Ecology |
---|---|
Main Authors: | , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2023
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1111/mec.17157 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.17157 |
id |
crwiley:10.1111/mec.17157 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1111/mec.17157 2024-03-31T07:51:17+00:00 Genetic features of bivalve transmissible neoplasia in blue mussels from the Kola Bay (Barents Sea) suggest a recent trans‐Arctic migration of the cancer lineages Skazina, Maria Ponomartsev, Nikita Maiorova, Mariia Khaitov, Vadim Marchenko, Julia Lentsman, Natalia Odintsova, Nelly Strelkov, Petr Russian Science Foundation 2023 http://dx.doi.org/10.1111/mec.17157 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.17157 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Molecular Ecology volume 32, issue 21, page 5724-5741 ISSN 0962-1083 1365-294X Genetics Ecology, Evolution, Behavior and Systematics journal-article 2023 crwiley https://doi.org/10.1111/mec.17157 2024-03-04T13:00:27Z Abstract Ecology and biogeography of bivalve transmissible neoplasia (BTN) are underexplored due to its recent discovery and a challenging diagnostics. Blue mussels harbour two evolutionary lineages of BTN, Mtr BTN1 and Mtr BTN2, both derived from Mytilus trossulus . Mtr BTN1 has been found only in M. trossulus from North Pacific. Mtr BTN2 parasitizes different Mytilus spp. worldwide. BTN in M. trossulus in the Atlantic sector has never been studied. We looked for BTN in mussels from the Barents Sea using flow cytometry of cells, qPCR with primers specific to cancer‐associated alleles and sequencing of mtDNA and nuclear loci. Both Mtr BTN1 and Mtr BTN2 were present in our material, though their prevalence was low (~0.4%). All cancers parasitized M. trossulus except one, Mtr BTN1, which was found in a hybrid between M. trossulus and M. edulis . The mtDNA haplotypes found in both lineages were nearly identical to those known from the Northwest Pacific but not from elsewhere. Our results suggest that these two lineages may have arrived in the Barents Sea in recent decades with the maritime transport along the Northern Sea Route. A young evolutionary age of Mtr BTN1 seems to indicate that it is an emerging disease in the process of niche expansion. Comparing the new and the published sequence data on tumour suppressor p53, we proved that the prevalence of BTN in mussels can reach epizootic levels. The finding of diverse recombinants between paternally and maternally inherited mtDNAs in somatic tissues of M. trossulus was an unexpected result of our study. Article in Journal/Newspaper Arctic Barents Sea Kola Bay Northern Sea Route Wiley Online Library Arctic Barents Sea Pacific Molecular Ecology 32 21 5724 5741 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
topic |
Genetics Ecology, Evolution, Behavior and Systematics |
spellingShingle |
Genetics Ecology, Evolution, Behavior and Systematics Skazina, Maria Ponomartsev, Nikita Maiorova, Mariia Khaitov, Vadim Marchenko, Julia Lentsman, Natalia Odintsova, Nelly Strelkov, Petr Genetic features of bivalve transmissible neoplasia in blue mussels from the Kola Bay (Barents Sea) suggest a recent trans‐Arctic migration of the cancer lineages |
topic_facet |
Genetics Ecology, Evolution, Behavior and Systematics |
description |
Abstract Ecology and biogeography of bivalve transmissible neoplasia (BTN) are underexplored due to its recent discovery and a challenging diagnostics. Blue mussels harbour two evolutionary lineages of BTN, Mtr BTN1 and Mtr BTN2, both derived from Mytilus trossulus . Mtr BTN1 has been found only in M. trossulus from North Pacific. Mtr BTN2 parasitizes different Mytilus spp. worldwide. BTN in M. trossulus in the Atlantic sector has never been studied. We looked for BTN in mussels from the Barents Sea using flow cytometry of cells, qPCR with primers specific to cancer‐associated alleles and sequencing of mtDNA and nuclear loci. Both Mtr BTN1 and Mtr BTN2 were present in our material, though their prevalence was low (~0.4%). All cancers parasitized M. trossulus except one, Mtr BTN1, which was found in a hybrid between M. trossulus and M. edulis . The mtDNA haplotypes found in both lineages were nearly identical to those known from the Northwest Pacific but not from elsewhere. Our results suggest that these two lineages may have arrived in the Barents Sea in recent decades with the maritime transport along the Northern Sea Route. A young evolutionary age of Mtr BTN1 seems to indicate that it is an emerging disease in the process of niche expansion. Comparing the new and the published sequence data on tumour suppressor p53, we proved that the prevalence of BTN in mussels can reach epizootic levels. The finding of diverse recombinants between paternally and maternally inherited mtDNAs in somatic tissues of M. trossulus was an unexpected result of our study. |
author2 |
Russian Science Foundation |
format |
Article in Journal/Newspaper |
author |
Skazina, Maria Ponomartsev, Nikita Maiorova, Mariia Khaitov, Vadim Marchenko, Julia Lentsman, Natalia Odintsova, Nelly Strelkov, Petr |
author_facet |
Skazina, Maria Ponomartsev, Nikita Maiorova, Mariia Khaitov, Vadim Marchenko, Julia Lentsman, Natalia Odintsova, Nelly Strelkov, Petr |
author_sort |
Skazina, Maria |
title |
Genetic features of bivalve transmissible neoplasia in blue mussels from the Kola Bay (Barents Sea) suggest a recent trans‐Arctic migration of the cancer lineages |
title_short |
Genetic features of bivalve transmissible neoplasia in blue mussels from the Kola Bay (Barents Sea) suggest a recent trans‐Arctic migration of the cancer lineages |
title_full |
Genetic features of bivalve transmissible neoplasia in blue mussels from the Kola Bay (Barents Sea) suggest a recent trans‐Arctic migration of the cancer lineages |
title_fullStr |
Genetic features of bivalve transmissible neoplasia in blue mussels from the Kola Bay (Barents Sea) suggest a recent trans‐Arctic migration of the cancer lineages |
title_full_unstemmed |
Genetic features of bivalve transmissible neoplasia in blue mussels from the Kola Bay (Barents Sea) suggest a recent trans‐Arctic migration of the cancer lineages |
title_sort |
genetic features of bivalve transmissible neoplasia in blue mussels from the kola bay (barents sea) suggest a recent trans‐arctic migration of the cancer lineages |
publisher |
Wiley |
publishDate |
2023 |
url |
http://dx.doi.org/10.1111/mec.17157 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.17157 |
geographic |
Arctic Barents Sea Pacific |
geographic_facet |
Arctic Barents Sea Pacific |
genre |
Arctic Barents Sea Kola Bay Northern Sea Route |
genre_facet |
Arctic Barents Sea Kola Bay Northern Sea Route |
op_source |
Molecular Ecology volume 32, issue 21, page 5724-5741 ISSN 0962-1083 1365-294X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/mec.17157 |
container_title |
Molecular Ecology |
container_volume |
32 |
container_issue |
21 |
container_start_page |
5724 |
op_container_end_page |
5741 |
_version_ |
1795029867995070464 |