Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares ( Lepus spp., Lagomorpha: Leporidae)
Abstract Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological and behavioural differences. Each species has travelled its own evolutionary trajectory, influenced by random drift and driven by...
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Online Access: | http://dx.doi.org/10.1111/mec.16755 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.16755 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/mec.16755 |
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crwiley:10.1111/mec.16755 2024-06-23T07:50:28+00:00 Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares ( Lepus spp., Lagomorpha: Leporidae) Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko L. O. Academy of Finland 2022 http://dx.doi.org/10.1111/mec.16755 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.16755 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/mec.16755 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Molecular Ecology volume 32, issue 15, page 4097-4117 ISSN 0962-1083 1365-294X journal-article 2022 crwiley https://doi.org/10.1111/mec.16755 2024-06-13T04:21:11Z Abstract Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological and behavioural differences. Each species has travelled its own evolutionary trajectory, influenced by random drift and driven by various types of natural selection, making the association of genetic differences between the species with the phenotypic differences extremely complex to dissect. In the present study, we have used an in vitro model to analyse in depth the genetic and gene regulation differences between fibroblasts of two closely related mammals, the arctic/subarctic mountain hare ( Lepus timidus Linnaeus) and the temperate steppe‐climate adapted brown hare ( Lepus europaeus Pallas). We discovered the existence of a species‐specific expression pattern of 1623 genes, manifesting in differences in cell growth, cell cycle control, respiration, and metabolism. Interspecific differences in the housekeeping functions of fibroblast cells suggest that speciation acts on fundamental cellular processes, even in these two interfertile species. Our results help to understand the molecular constituents of a species difference on a cellular level, which could contribute to the maintenance of the species boundary. Article in Journal/Newspaper Arctic Lepus timidus mountain hare Subarctic Wiley Online Library Arctic Molecular Ecology 32 15 4097 4117 |
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Wiley Online Library |
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English |
description |
Abstract Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological and behavioural differences. Each species has travelled its own evolutionary trajectory, influenced by random drift and driven by various types of natural selection, making the association of genetic differences between the species with the phenotypic differences extremely complex to dissect. In the present study, we have used an in vitro model to analyse in depth the genetic and gene regulation differences between fibroblasts of two closely related mammals, the arctic/subarctic mountain hare ( Lepus timidus Linnaeus) and the temperate steppe‐climate adapted brown hare ( Lepus europaeus Pallas). We discovered the existence of a species‐specific expression pattern of 1623 genes, manifesting in differences in cell growth, cell cycle control, respiration, and metabolism. Interspecific differences in the housekeeping functions of fibroblast cells suggest that speciation acts on fundamental cellular processes, even in these two interfertile species. Our results help to understand the molecular constituents of a species difference on a cellular level, which could contribute to the maintenance of the species boundary. |
author2 |
Academy of Finland |
format |
Article in Journal/Newspaper |
author |
Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko L. O. |
spellingShingle |
Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko L. O. Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares ( Lepus spp., Lagomorpha: Leporidae) |
author_facet |
Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko L. O. |
author_sort |
Gaertner, Kateryna |
title |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares ( Lepus spp., Lagomorpha: Leporidae) |
title_short |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares ( Lepus spp., Lagomorpha: Leporidae) |
title_full |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares ( Lepus spp., Lagomorpha: Leporidae) |
title_fullStr |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares ( Lepus spp., Lagomorpha: Leporidae) |
title_full_unstemmed |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares ( Lepus spp., Lagomorpha: Leporidae) |
title_sort |
molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares ( lepus spp., lagomorpha: leporidae) |
publisher |
Wiley |
publishDate |
2022 |
url |
http://dx.doi.org/10.1111/mec.16755 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.16755 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/mec.16755 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Lepus timidus mountain hare Subarctic |
genre_facet |
Arctic Lepus timidus mountain hare Subarctic |
op_source |
Molecular Ecology volume 32, issue 15, page 4097-4117 ISSN 0962-1083 1365-294X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/mec.16755 |
container_title |
Molecular Ecology |
container_volume |
32 |
container_issue |
15 |
container_start_page |
4097 |
op_container_end_page |
4117 |
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1802641365264236544 |