, Jost's D , and <scp> F ST </scp> are similarly constrained by allele frequencies: A mathematical, simulation, and empirical study
Abstract Statistics and Jost's D have been proposed for replacing F ST as measures of genetic differentiation. A principal argument in favour of these statistics is the independence of their maximal values with respect to the subpopulation heterozygosity H S , a property not shared by F ST . Ne...
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crwiley:10.1111/mec.15000 2024-04-21T07:57:27+00:00 , Jost's D , and <scp> F ST </scp> are similarly constrained by allele frequencies: A mathematical, simulation, and empirical study Alcala, Nicolas Rosenberg, Noah A. Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung National Institutes of Health 2019 http://dx.doi.org/10.1111/mec.15000 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.15000 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.15000 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/mec.15000 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Molecular Ecology volume 28, issue 7, page 1624-1636 ISSN 0962-1083 1365-294X Genetics Ecology, Evolution, Behavior and Systematics journal-article 2019 crwiley https://doi.org/10.1111/mec.15000 2024-03-26T09:11:16Z Abstract Statistics and Jost's D have been proposed for replacing F ST as measures of genetic differentiation. A principal argument in favour of these statistics is the independence of their maximal values with respect to the subpopulation heterozygosity H S , a property not shared by F ST . Nevertheless, it has been unclear if these alternative differentiation measures are constrained by other aspects of the allele frequencies. Here, for biallelic markers, we study the mathematical properties of the maximal values of and D , comparing them to those of F ST . We show that and D exhibit the same peculiar frequency‐dependence phenomena as F ST , including a maximal value as a function of the frequency of the most frequent allele that lies well below one. Although the functions describing , D , and F ST in terms of the frequency of the most frequent allele are different, the allele frequencies that maximize them are identical. Moreover, we show using coalescent simulations that when taking into account the specific maximal values of the three statistics, their behaviours become similar across a large range of migration rates. We use our results to explain two empirical patterns: the similar values of the three statistics among North American wolves, and the low D values compared to and F ST in Atlantic salmon. The results suggest that the three statistics are often predictably similar, so that they can make quite similar contributions to data analysis. When they are not similar, the difference can be understood in relation to features of genetic diversity. Article in Journal/Newspaper Atlantic salmon Wiley Online Library Molecular Ecology 28 7 1624 1636 |
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language |
English |
topic |
Genetics Ecology, Evolution, Behavior and Systematics |
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Genetics Ecology, Evolution, Behavior and Systematics Alcala, Nicolas Rosenberg, Noah A. , Jost's D , and <scp> F ST </scp> are similarly constrained by allele frequencies: A mathematical, simulation, and empirical study |
topic_facet |
Genetics Ecology, Evolution, Behavior and Systematics |
description |
Abstract Statistics and Jost's D have been proposed for replacing F ST as measures of genetic differentiation. A principal argument in favour of these statistics is the independence of their maximal values with respect to the subpopulation heterozygosity H S , a property not shared by F ST . Nevertheless, it has been unclear if these alternative differentiation measures are constrained by other aspects of the allele frequencies. Here, for biallelic markers, we study the mathematical properties of the maximal values of and D , comparing them to those of F ST . We show that and D exhibit the same peculiar frequency‐dependence phenomena as F ST , including a maximal value as a function of the frequency of the most frequent allele that lies well below one. Although the functions describing , D , and F ST in terms of the frequency of the most frequent allele are different, the allele frequencies that maximize them are identical. Moreover, we show using coalescent simulations that when taking into account the specific maximal values of the three statistics, their behaviours become similar across a large range of migration rates. We use our results to explain two empirical patterns: the similar values of the three statistics among North American wolves, and the low D values compared to and F ST in Atlantic salmon. The results suggest that the three statistics are often predictably similar, so that they can make quite similar contributions to data analysis. When they are not similar, the difference can be understood in relation to features of genetic diversity. |
author2 |
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung National Institutes of Health |
format |
Article in Journal/Newspaper |
author |
Alcala, Nicolas Rosenberg, Noah A. |
author_facet |
Alcala, Nicolas Rosenberg, Noah A. |
author_sort |
Alcala, Nicolas |
title |
, Jost's D , and <scp> F ST </scp> are similarly constrained by allele frequencies: A mathematical, simulation, and empirical study |
title_short |
, Jost's D , and <scp> F ST </scp> are similarly constrained by allele frequencies: A mathematical, simulation, and empirical study |
title_full |
, Jost's D , and <scp> F ST </scp> are similarly constrained by allele frequencies: A mathematical, simulation, and empirical study |
title_fullStr |
, Jost's D , and <scp> F ST </scp> are similarly constrained by allele frequencies: A mathematical, simulation, and empirical study |
title_full_unstemmed |
, Jost's D , and <scp> F ST </scp> are similarly constrained by allele frequencies: A mathematical, simulation, and empirical study |
title_sort |
, jost's d , and <scp> f st </scp> are similarly constrained by allele frequencies: a mathematical, simulation, and empirical study |
publisher |
Wiley |
publishDate |
2019 |
url |
http://dx.doi.org/10.1111/mec.15000 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.15000 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.15000 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/mec.15000 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Molecular Ecology volume 28, issue 7, page 1624-1636 ISSN 0962-1083 1365-294X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/mec.15000 |
container_title |
Molecular Ecology |
container_volume |
28 |
container_issue |
7 |
container_start_page |
1624 |
op_container_end_page |
1636 |
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1796939083220516864 |