Inferences of genetic architecture of bill morphology in house sparrow using a high‐density SNP array point to a polygenic basis
Abstract Understanding the genetic architecture of quantitative traits can provide insights into the mechanisms driving phenotypic evolution. Bill morphology is an ecologically important and phenotypically variable trait, which is highly heritable and closely linked to individual fitness. Thus, bill...
Published in: | Molecular Ecology |
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Online Access: | http://dx.doi.org/10.1111/mec.14811 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.14811 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.14811 |
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crwiley:10.1111/mec.14811 2024-06-23T07:55:33+00:00 Inferences of genetic architecture of bill morphology in house sparrow using a high‐density SNP array point to a polygenic basis Lundregan, Sarah L. Hagen, Ingerid J. Gohli, Jostein Niskanen, Alina K. Kemppainen, Petri Ringsby, Thor Harald Kvalnes, Thomas Pärn, Henrik Rønning, Bernt Holand, Håkon Ranke, Peter S. Båtnes, Anna S. Selvik, Linn‐Karina Lien, Sigbjørn Sæther, Bernt‐Erik Husby, Arild Jensen, Henrik Academy of Finland Norges Forskningsråd 2018 http://dx.doi.org/10.1111/mec.14811 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.14811 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.14811 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Molecular Ecology volume 27, issue 17, page 3498-3514 ISSN 0962-1083 1365-294X journal-article 2018 crwiley https://doi.org/10.1111/mec.14811 2024-06-13T04:22:55Z Abstract Understanding the genetic architecture of quantitative traits can provide insights into the mechanisms driving phenotypic evolution. Bill morphology is an ecologically important and phenotypically variable trait, which is highly heritable and closely linked to individual fitness. Thus, bill morphology traits are suitable candidates for gene mapping analyses. Previous studies have revealed several genes that may influence bill morphology, but the similarity of gene and allele effects between species and populations is unknown. Here, we develop a custom 200K SNP array and use it to examine the genetic basis of bill morphology in 1857 house sparrow individuals from a large‐scale, island metapopulation off the coast of Northern Norway. We found high genomic heritabilities for bill depth and length, which were comparable with previous pedigree estimates. Candidate gene and genomewide association analyses yielded six significant loci, four of which have previously been associated with craniofacial development. Three of these loci are involved in bone morphogenic protein ( BMP ) signalling, suggesting a role for BMP genes in regulating bill morphology. However, these loci individually explain a small amount of variance. In combination with results from genome partitioning analyses, this indicates that bill morphology is a polygenic trait. Any studies of eco‐evolutionary processes in bill morphology are therefore dependent on methods that can accommodate polygenic inheritance of the phenotype and molecular‐scale evolution of genetic architecture. Article in Journal/Newspaper Northern Norway Wiley Online Library Norway Molecular Ecology 27 17 3498 3514 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract Understanding the genetic architecture of quantitative traits can provide insights into the mechanisms driving phenotypic evolution. Bill morphology is an ecologically important and phenotypically variable trait, which is highly heritable and closely linked to individual fitness. Thus, bill morphology traits are suitable candidates for gene mapping analyses. Previous studies have revealed several genes that may influence bill morphology, but the similarity of gene and allele effects between species and populations is unknown. Here, we develop a custom 200K SNP array and use it to examine the genetic basis of bill morphology in 1857 house sparrow individuals from a large‐scale, island metapopulation off the coast of Northern Norway. We found high genomic heritabilities for bill depth and length, which were comparable with previous pedigree estimates. Candidate gene and genomewide association analyses yielded six significant loci, four of which have previously been associated with craniofacial development. Three of these loci are involved in bone morphogenic protein ( BMP ) signalling, suggesting a role for BMP genes in regulating bill morphology. However, these loci individually explain a small amount of variance. In combination with results from genome partitioning analyses, this indicates that bill morphology is a polygenic trait. Any studies of eco‐evolutionary processes in bill morphology are therefore dependent on methods that can accommodate polygenic inheritance of the phenotype and molecular‐scale evolution of genetic architecture. |
author2 |
Academy of Finland Norges Forskningsråd |
format |
Article in Journal/Newspaper |
author |
Lundregan, Sarah L. Hagen, Ingerid J. Gohli, Jostein Niskanen, Alina K. Kemppainen, Petri Ringsby, Thor Harald Kvalnes, Thomas Pärn, Henrik Rønning, Bernt Holand, Håkon Ranke, Peter S. Båtnes, Anna S. Selvik, Linn‐Karina Lien, Sigbjørn Sæther, Bernt‐Erik Husby, Arild Jensen, Henrik |
spellingShingle |
Lundregan, Sarah L. Hagen, Ingerid J. Gohli, Jostein Niskanen, Alina K. Kemppainen, Petri Ringsby, Thor Harald Kvalnes, Thomas Pärn, Henrik Rønning, Bernt Holand, Håkon Ranke, Peter S. Båtnes, Anna S. Selvik, Linn‐Karina Lien, Sigbjørn Sæther, Bernt‐Erik Husby, Arild Jensen, Henrik Inferences of genetic architecture of bill morphology in house sparrow using a high‐density SNP array point to a polygenic basis |
author_facet |
Lundregan, Sarah L. Hagen, Ingerid J. Gohli, Jostein Niskanen, Alina K. Kemppainen, Petri Ringsby, Thor Harald Kvalnes, Thomas Pärn, Henrik Rønning, Bernt Holand, Håkon Ranke, Peter S. Båtnes, Anna S. Selvik, Linn‐Karina Lien, Sigbjørn Sæther, Bernt‐Erik Husby, Arild Jensen, Henrik |
author_sort |
Lundregan, Sarah L. |
title |
Inferences of genetic architecture of bill morphology in house sparrow using a high‐density SNP array point to a polygenic basis |
title_short |
Inferences of genetic architecture of bill morphology in house sparrow using a high‐density SNP array point to a polygenic basis |
title_full |
Inferences of genetic architecture of bill morphology in house sparrow using a high‐density SNP array point to a polygenic basis |
title_fullStr |
Inferences of genetic architecture of bill morphology in house sparrow using a high‐density SNP array point to a polygenic basis |
title_full_unstemmed |
Inferences of genetic architecture of bill morphology in house sparrow using a high‐density SNP array point to a polygenic basis |
title_sort |
inferences of genetic architecture of bill morphology in house sparrow using a high‐density snp array point to a polygenic basis |
publisher |
Wiley |
publishDate |
2018 |
url |
http://dx.doi.org/10.1111/mec.14811 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.14811 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.14811 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Northern Norway |
genre_facet |
Northern Norway |
op_source |
Molecular Ecology volume 27, issue 17, page 3498-3514 ISSN 0962-1083 1365-294X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/mec.14811 |
container_title |
Molecular Ecology |
container_volume |
27 |
container_issue |
17 |
container_start_page |
3498 |
op_container_end_page |
3514 |
_version_ |
1802648198551961600 |