Life‐stage‐associated remodelling of lipid metabolism regulation in Atlantic salmon
Abstract Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens and shift in dietary lipid availabi...
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Online Access: | http://dx.doi.org/10.1111/mec.14533 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.14533 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.14533 |
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crwiley:10.1111/mec.14533 2024-06-23T07:51:16+00:00 Life‐stage‐associated remodelling of lipid metabolism regulation in Atlantic salmon Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjørn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen R. DigiSal NFR GenoSysFat NFR 2018 http://dx.doi.org/10.1111/mec.14533 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.14533 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.14533 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor http://doi.wiley.com/10.1002/tdm_license_1.1 http://onlinelibrary.wiley.com/termsAndConditions#vor Molecular Ecology volume 27, issue 5, page 1200-1213 ISSN 0962-1083 1365-294X journal-article 2018 crwiley https://doi.org/10.1111/mec.14533 2024-06-06T04:24:51Z Abstract Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens and shift in dietary lipid availability. Many changes in physiology and metabolism occur across this life‐stage transition, but little is known about the molecular nature of these changes. Here, we use a long‐term feeding experiment to study transcriptional regulation of lipid metabolism in Atlantic salmon gut and liver in both fresh‐ and saltwater. We find that lipid metabolism becomes significantly less plastic to differences in dietary lipid composition when salmon transitions to saltwater and experiences increased dietary lipid availability. Expression of genes in liver relating to lipogenesis and lipid transport decreases overall and becomes less responsive to diet, while genes for lipid uptake in gut become more highly expressed. Finally, analyses of evolutionary consequences of the salmonid‐specific whole‐genome duplication on lipid metabolism reveal several pathways with significantly different ( p < .05) duplicate retention or duplicate regulatory conservation. We also find a limited number of cases where the whole‐genome duplication has resulted in an increased gene dosage. In conclusion, we find variable and pathway‐specific effects of the salmonid genome duplication on lipid metabolism genes. A clear life‐stage‐associated shift in lipid metabolism regulation is evident, and we hypothesize this to be, at least partly, driven by nondietary factors such as the preparatory remodelling of gene regulation and physiology prior to sea migration. Article in Journal/Newspaper Atlantic salmon Wiley Online Library Molecular Ecology 27 5 1200 1213 |
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Wiley Online Library |
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language |
English |
description |
Abstract Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens and shift in dietary lipid availability. Many changes in physiology and metabolism occur across this life‐stage transition, but little is known about the molecular nature of these changes. Here, we use a long‐term feeding experiment to study transcriptional regulation of lipid metabolism in Atlantic salmon gut and liver in both fresh‐ and saltwater. We find that lipid metabolism becomes significantly less plastic to differences in dietary lipid composition when salmon transitions to saltwater and experiences increased dietary lipid availability. Expression of genes in liver relating to lipogenesis and lipid transport decreases overall and becomes less responsive to diet, while genes for lipid uptake in gut become more highly expressed. Finally, analyses of evolutionary consequences of the salmonid‐specific whole‐genome duplication on lipid metabolism reveal several pathways with significantly different ( p < .05) duplicate retention or duplicate regulatory conservation. We also find a limited number of cases where the whole‐genome duplication has resulted in an increased gene dosage. In conclusion, we find variable and pathway‐specific effects of the salmonid genome duplication on lipid metabolism genes. A clear life‐stage‐associated shift in lipid metabolism regulation is evident, and we hypothesize this to be, at least partly, driven by nondietary factors such as the preparatory remodelling of gene regulation and physiology prior to sea migration. |
author2 |
DigiSal NFR GenoSysFat NFR |
format |
Article in Journal/Newspaper |
author |
Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjørn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen R. |
spellingShingle |
Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjørn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen R. Life‐stage‐associated remodelling of lipid metabolism regulation in Atlantic salmon |
author_facet |
Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjørn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen R. |
author_sort |
Gillard, Gareth |
title |
Life‐stage‐associated remodelling of lipid metabolism regulation in Atlantic salmon |
title_short |
Life‐stage‐associated remodelling of lipid metabolism regulation in Atlantic salmon |
title_full |
Life‐stage‐associated remodelling of lipid metabolism regulation in Atlantic salmon |
title_fullStr |
Life‐stage‐associated remodelling of lipid metabolism regulation in Atlantic salmon |
title_full_unstemmed |
Life‐stage‐associated remodelling of lipid metabolism regulation in Atlantic salmon |
title_sort |
life‐stage‐associated remodelling of lipid metabolism regulation in atlantic salmon |
publisher |
Wiley |
publishDate |
2018 |
url |
http://dx.doi.org/10.1111/mec.14533 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.14533 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.14533 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Molecular Ecology volume 27, issue 5, page 1200-1213 ISSN 0962-1083 1365-294X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor http://doi.wiley.com/10.1002/tdm_license_1.1 http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/mec.14533 |
container_title |
Molecular Ecology |
container_volume |
27 |
container_issue |
5 |
container_start_page |
1200 |
op_container_end_page |
1213 |
_version_ |
1802642303564644352 |