Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska
Abstract For pathogens that infect multiple species, the distinction between reservoir hosts and spillover hosts is often difficult. In Alaska, three variants of the arctic rabies virus exist with distinct spatial distributions. We tested the hypothesis that rabies virus variant distribution corresp...
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Online Access: | http://dx.doi.org/10.1111/mec.13509 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.13509 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.13509 |
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crwiley:10.1111/mec.13509 2024-09-15T17:52:35+00:00 Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten National Center for Research Resources National Institute of General Medical Sciences UAF Office of Undergraduate Research and Scholarly Activities Alaska INBRE National Center for Research Resources National Institute of General Medical Sciences 2016 http://dx.doi.org/10.1111/mec.13509 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.13509 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.13509 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor http://doi.wiley.com/10.1002/tdm_license_1.1 Molecular Ecology volume 25, issue 3, page 675-688 ISSN 0962-1083 1365-294X journal-article 2016 crwiley https://doi.org/10.1111/mec.13509 2024-07-11T04:35:12Z Abstract For pathogens that infect multiple species, the distinction between reservoir hosts and spillover hosts is often difficult. In Alaska, three variants of the arctic rabies virus exist with distinct spatial distributions. We tested the hypothesis that rabies virus variant distribution corresponds to the population structure of the primary rabies hosts in Alaska, arctic foxes ( Vulpes lagopus ) and red foxes ( Vulpes vulpes ) to possibly distinguish reservoir and spillover hosts. We used mitochondrial DNA (mt DNA ) sequence and nine microsatellites to assess population structure in those two species. mt DNA structure did not correspond to rabies virus variant structure in either species. Microsatellite analyses gave varying results. Bayesian clustering found two groups of arctic foxes in the coastal tundra region, but for red foxes it identified tundra and boreal types. Spatial Bayesian clustering and spatial principal components analysis identified 3 and 4 groups of arctic foxes, respectively, closely matching the distribution of rabies virus variants in the state. Red foxes, conversely, showed eight clusters comprising two regions (boreal and tundra) with much admixture. These results run contrary to previous beliefs that arctic fox show no fine‐scale spatial population structure. While we cannot rule out that the red fox is part of the maintenance host community for rabies in Alaska, the distribution of virus variants appears to be driven primarily by the arctic fox. Therefore, we show that host population genetics can be utilized to distinguish between maintenance and spillover hosts when used in conjunction with other approaches. Article in Journal/Newspaper Arctic Fox Tundra Vulpes lagopus Alaska Wiley Online Library Molecular Ecology 25 3 675 688 |
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Wiley Online Library |
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crwiley |
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English |
description |
Abstract For pathogens that infect multiple species, the distinction between reservoir hosts and spillover hosts is often difficult. In Alaska, three variants of the arctic rabies virus exist with distinct spatial distributions. We tested the hypothesis that rabies virus variant distribution corresponds to the population structure of the primary rabies hosts in Alaska, arctic foxes ( Vulpes lagopus ) and red foxes ( Vulpes vulpes ) to possibly distinguish reservoir and spillover hosts. We used mitochondrial DNA (mt DNA ) sequence and nine microsatellites to assess population structure in those two species. mt DNA structure did not correspond to rabies virus variant structure in either species. Microsatellite analyses gave varying results. Bayesian clustering found two groups of arctic foxes in the coastal tundra region, but for red foxes it identified tundra and boreal types. Spatial Bayesian clustering and spatial principal components analysis identified 3 and 4 groups of arctic foxes, respectively, closely matching the distribution of rabies virus variants in the state. Red foxes, conversely, showed eight clusters comprising two regions (boreal and tundra) with much admixture. These results run contrary to previous beliefs that arctic fox show no fine‐scale spatial population structure. While we cannot rule out that the red fox is part of the maintenance host community for rabies in Alaska, the distribution of virus variants appears to be driven primarily by the arctic fox. Therefore, we show that host population genetics can be utilized to distinguish between maintenance and spillover hosts when used in conjunction with other approaches. |
author2 |
National Center for Research Resources National Institute of General Medical Sciences UAF Office of Undergraduate Research and Scholarly Activities Alaska INBRE National Center for Research Resources National Institute of General Medical Sciences |
format |
Article in Journal/Newspaper |
author |
Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten |
spellingShingle |
Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
author_facet |
Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten |
author_sort |
Goldsmith, Elizabeth W. |
title |
Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_short |
Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_full |
Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_fullStr |
Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_full_unstemmed |
Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_sort |
population structure of two rabies hosts relative to the known distribution of rabies virus variants in alaska |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1111/mec.13509 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.13509 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.13509 |
genre |
Arctic Fox Tundra Vulpes lagopus Alaska |
genre_facet |
Arctic Fox Tundra Vulpes lagopus Alaska |
op_source |
Molecular Ecology volume 25, issue 3, page 675-688 ISSN 0962-1083 1365-294X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor http://doi.wiley.com/10.1002/tdm_license_1.1 |
op_doi |
https://doi.org/10.1111/mec.13509 |
container_title |
Molecular Ecology |
container_volume |
25 |
container_issue |
3 |
container_start_page |
675 |
op_container_end_page |
688 |
_version_ |
1810294648679170048 |