Germline <scp>DNA</scp> methylation in reef corals: patterns and potential roles in response to environmental change
Abstract DNA methylation is an epigenetic mark that plays an inadequately understood role in gene regulation, particularly in nonmodel species. Because it can be influenced by the environment, DNA methylation may contribute to the ability of organisms to acclimatize and adapt to environmental change...
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crwiley:10.1111/mec.13414 2024-04-28T08:34:54+00:00 Germline <scp>DNA</scp> methylation in reef corals: patterns and potential roles in response to environmental change Dimond, James L. Roberts, Steven B. School of Aquatic and Fishery Sciences Achievement Rewards for College Scientists Foundation School of Aquatic and Fishery Sciences Achievement Rewards for College Scientists Foundation 2016 http://dx.doi.org/10.1111/mec.13414 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.13414 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.13414 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor http://doi.wiley.com/10.1002/tdm_license_1.1 Molecular Ecology volume 25, issue 8, page 1895-1904 ISSN 0962-1083 1365-294X Genetics Ecology, Evolution, Behavior and Systematics journal-article 2016 crwiley https://doi.org/10.1111/mec.13414 2024-04-08T06:55:13Z Abstract DNA methylation is an epigenetic mark that plays an inadequately understood role in gene regulation, particularly in nonmodel species. Because it can be influenced by the environment, DNA methylation may contribute to the ability of organisms to acclimatize and adapt to environmental change. We evaluated the distribution of gene body methylation in reef‐building corals, a group of organisms facing significant environmental threats. Gene body methylation in six species of corals was inferred from in silico transcriptome analysis of CpG O/E, an estimate of germline DNA methylation that is highly correlated with patterns of methylation enrichment. Consistent with what has been documented in most other invertebrates, all corals exhibited bimodal distributions of germline methylation suggestive of distinct fractions of genes with high and low levels of methylation. The hypermethylated fractions were enriched with genes with housekeeping functions, while genes with inducible functions were highly represented in the hypomethylated fractions. High transcript abundance was associated with intermediate levels of methylation. In three of the coral species, we found that genes differentially expressed in response to thermal stress and ocean acidification exhibited significantly lower levels of methylation. These results support a link between gene body hypomethylation and transcriptional plasticity that may point to a role of DNA methylation in the response of corals to environmental change. Article in Journal/Newspaper Ocean acidification Wiley Online Library Molecular Ecology 25 8 1895 1904 |
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English |
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Genetics Ecology, Evolution, Behavior and Systematics |
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Genetics Ecology, Evolution, Behavior and Systematics Dimond, James L. Roberts, Steven B. Germline <scp>DNA</scp> methylation in reef corals: patterns and potential roles in response to environmental change |
topic_facet |
Genetics Ecology, Evolution, Behavior and Systematics |
description |
Abstract DNA methylation is an epigenetic mark that plays an inadequately understood role in gene regulation, particularly in nonmodel species. Because it can be influenced by the environment, DNA methylation may contribute to the ability of organisms to acclimatize and adapt to environmental change. We evaluated the distribution of gene body methylation in reef‐building corals, a group of organisms facing significant environmental threats. Gene body methylation in six species of corals was inferred from in silico transcriptome analysis of CpG O/E, an estimate of germline DNA methylation that is highly correlated with patterns of methylation enrichment. Consistent with what has been documented in most other invertebrates, all corals exhibited bimodal distributions of germline methylation suggestive of distinct fractions of genes with high and low levels of methylation. The hypermethylated fractions were enriched with genes with housekeeping functions, while genes with inducible functions were highly represented in the hypomethylated fractions. High transcript abundance was associated with intermediate levels of methylation. In three of the coral species, we found that genes differentially expressed in response to thermal stress and ocean acidification exhibited significantly lower levels of methylation. These results support a link between gene body hypomethylation and transcriptional plasticity that may point to a role of DNA methylation in the response of corals to environmental change. |
author2 |
School of Aquatic and Fishery Sciences Achievement Rewards for College Scientists Foundation School of Aquatic and Fishery Sciences Achievement Rewards for College Scientists Foundation |
format |
Article in Journal/Newspaper |
author |
Dimond, James L. Roberts, Steven B. |
author_facet |
Dimond, James L. Roberts, Steven B. |
author_sort |
Dimond, James L. |
title |
Germline <scp>DNA</scp> methylation in reef corals: patterns and potential roles in response to environmental change |
title_short |
Germline <scp>DNA</scp> methylation in reef corals: patterns and potential roles in response to environmental change |
title_full |
Germline <scp>DNA</scp> methylation in reef corals: patterns and potential roles in response to environmental change |
title_fullStr |
Germline <scp>DNA</scp> methylation in reef corals: patterns and potential roles in response to environmental change |
title_full_unstemmed |
Germline <scp>DNA</scp> methylation in reef corals: patterns and potential roles in response to environmental change |
title_sort |
germline <scp>dna</scp> methylation in reef corals: patterns and potential roles in response to environmental change |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1111/mec.13414 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.13414 https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.13414 |
genre |
Ocean acidification |
genre_facet |
Ocean acidification |
op_source |
Molecular Ecology volume 25, issue 8, page 1895-1904 ISSN 0962-1083 1365-294X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor http://doi.wiley.com/10.1002/tdm_license_1.1 |
op_doi |
https://doi.org/10.1111/mec.13414 |
container_title |
Molecular Ecology |
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25 |
container_issue |
8 |
container_start_page |
1895 |
op_container_end_page |
1904 |
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1797591429079367680 |