Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in <scp>A</scp>tlantic salmon's ( <scp>S</scp>almo salar ) muscle after oral administration in feed
Ribavirin is an antiviral used in human medicine, but it has not been authorized for use in veterinary medicine although it is effective against infectious salmon anemia ( ISA ) virus, between others. In this study, we present a pharmacokinetic profile of ribavirin in Atlantic salmon ( Salmo salar )...
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crwiley:10.1111/jvp.12288 2024-03-24T09:00:39+00:00 Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in <scp>A</scp>tlantic salmon's ( <scp>S</scp>almo salar ) muscle after oral administration in feed San Martín, B. Muñoz, R. Cornejo, J. Martínez, M. A. Araya‐Jordán, C. Maddaleno, A. Anadón, A. 2016 http://dx.doi.org/10.1111/jvp.12288 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjvp.12288 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jvp.12288 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Veterinary Pharmacology and Therapeutics volume 39, issue 4, page 388-397 ISSN 0140-7783 1365-2885 General Veterinary Pharmacology journal-article 2016 crwiley https://doi.org/10.1111/jvp.12288 2024-02-28T02:09:32Z Ribavirin is an antiviral used in human medicine, but it has not been authorized for use in veterinary medicine although it is effective against infectious salmon anemia ( ISA ) virus, between others. In this study, we present a pharmacokinetic profile of ribavirin in Atlantic salmon ( Salmo salar ), efficacy prediction indexes, and the measure of its withdrawal time. To determine the pharmacokinetic profile, fishes were orally administered with a single ribavirin dose of 1.6 mg/kg bw, and then, plasma concentrations were measured at different times. From the time‐vs.‐concentration curve, Cmax = 413.57 ng/mL, T max = 6.96 h, AUC = 21394.01 μg·h/mL, t 1/2 = 81.61 h, and K 10 = 0.0421/h were obtained. Ribavirin reached adequate concentrations during the pharmacokinetic study, with prediction indexes of C max / IC 50 = 20.7, AUC / IC 50 = 1069.7, and T> IC 50 = 71 h, where IC is the inhibitory concentration 50%. For ribavirin depletion study, fishes were orally administered with a dairy dose of 1.6 mg/kg bw during 10 days. Concentrations were measured on edible tissue on different days post‐treatment. A linear regression of the time vs. concentration was conducted, obtaining a withdrawal time of 1966 °C days. Results obtained reveal that the dose of 1.6 mg/kg bw orally administered is effective for ISA virus, originating a reasonable withdrawal period within the productive schedules of Atlantic salmon. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library Almo ENVELOPE(15.306,15.306,66.954,66.954) Journal of Veterinary Pharmacology and Therapeutics 39 4 388 397 |
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Wiley Online Library |
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crwiley |
language |
English |
topic |
General Veterinary Pharmacology |
spellingShingle |
General Veterinary Pharmacology San Martín, B. Muñoz, R. Cornejo, J. Martínez, M. A. Araya‐Jordán, C. Maddaleno, A. Anadón, A. Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in <scp>A</scp>tlantic salmon's ( <scp>S</scp>almo salar ) muscle after oral administration in feed |
topic_facet |
General Veterinary Pharmacology |
description |
Ribavirin is an antiviral used in human medicine, but it has not been authorized for use in veterinary medicine although it is effective against infectious salmon anemia ( ISA ) virus, between others. In this study, we present a pharmacokinetic profile of ribavirin in Atlantic salmon ( Salmo salar ), efficacy prediction indexes, and the measure of its withdrawal time. To determine the pharmacokinetic profile, fishes were orally administered with a single ribavirin dose of 1.6 mg/kg bw, and then, plasma concentrations were measured at different times. From the time‐vs.‐concentration curve, Cmax = 413.57 ng/mL, T max = 6.96 h, AUC = 21394.01 μg·h/mL, t 1/2 = 81.61 h, and K 10 = 0.0421/h were obtained. Ribavirin reached adequate concentrations during the pharmacokinetic study, with prediction indexes of C max / IC 50 = 20.7, AUC / IC 50 = 1069.7, and T> IC 50 = 71 h, where IC is the inhibitory concentration 50%. For ribavirin depletion study, fishes were orally administered with a dairy dose of 1.6 mg/kg bw during 10 days. Concentrations were measured on edible tissue on different days post‐treatment. A linear regression of the time vs. concentration was conducted, obtaining a withdrawal time of 1966 °C days. Results obtained reveal that the dose of 1.6 mg/kg bw orally administered is effective for ISA virus, originating a reasonable withdrawal period within the productive schedules of Atlantic salmon. |
format |
Article in Journal/Newspaper |
author |
San Martín, B. Muñoz, R. Cornejo, J. Martínez, M. A. Araya‐Jordán, C. Maddaleno, A. Anadón, A. |
author_facet |
San Martín, B. Muñoz, R. Cornejo, J. Martínez, M. A. Araya‐Jordán, C. Maddaleno, A. Anadón, A. |
author_sort |
San Martín, B. |
title |
Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in <scp>A</scp>tlantic salmon's ( <scp>S</scp>almo salar ) muscle after oral administration in feed |
title_short |
Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in <scp>A</scp>tlantic salmon's ( <scp>S</scp>almo salar ) muscle after oral administration in feed |
title_full |
Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in <scp>A</scp>tlantic salmon's ( <scp>S</scp>almo salar ) muscle after oral administration in feed |
title_fullStr |
Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in <scp>A</scp>tlantic salmon's ( <scp>S</scp>almo salar ) muscle after oral administration in feed |
title_full_unstemmed |
Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in <scp>A</scp>tlantic salmon's ( <scp>S</scp>almo salar ) muscle after oral administration in feed |
title_sort |
pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in <scp>a</scp>tlantic salmon's ( <scp>s</scp>almo salar ) muscle after oral administration in feed |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1111/jvp.12288 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjvp.12288 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jvp.12288 |
long_lat |
ENVELOPE(15.306,15.306,66.954,66.954) |
geographic |
Almo |
geographic_facet |
Almo |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Veterinary Pharmacology and Therapeutics volume 39, issue 4, page 388-397 ISSN 0140-7783 1365-2885 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/jvp.12288 |
container_title |
Journal of Veterinary Pharmacology and Therapeutics |
container_volume |
39 |
container_issue |
4 |
container_start_page |
388 |
op_container_end_page |
397 |
_version_ |
1794400543980912640 |