Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in <scp>A</scp>tlantic salmon's ( <scp>S</scp>almo salar ) muscle after oral administration in feed

• Published in: Journal of Veterinary Pharmacology and Therapeutics
• Main Authors: San Martín, B., Muñoz, R., Cornejo, J., Martínez, M. A., Araya‐Jordán, C., Maddaleno, A., Anadón, A.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2016
• Subjects: General Veterinary; Pharmacology; Almo; Atlantic salmon; Salmo salar
• Online Access: http://dx.doi.org/10.1111/jvp.12288; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjvp.12288; https://onlinelibrary.wiley.com/doi/pdf/10.1111/jvp.12288

Ribavirin is an antiviral used in human medicine, but it has not been authorized for use in veterinary medicine although it is effective against infectious salmon anemia ( ISA ) virus, between others. In this study, we present a pharmacokinetic profile of ribavirin in Atlantic salmon ( Salmo salar ), efficacy prediction indexes, and the measure of its withdrawal time. To determine the pharmacokinetic profile, fishes were orally administered with a single ribavirin dose of 1.6 mg/kg bw, and then, plasma concentrations were measured at different times. From the time‐vs.‐concentration curve, Cmax = 413.57 ng/mL, T max = 6.96 h, AUC = 21394.01 μg·h/mL, t 1/2 = 81.61 h, and K 10 = 0.0421/h were obtained. Ribavirin reached adequate concentrations during the pharmacokinetic study, with prediction indexes of C max / IC 50 = 20.7, AUC / IC 50 = 1069.7, and T> IC 50 = 71 h, where IC is the inhibitory concentration 50%. For ribavirin depletion study, fishes were orally administered with a dairy dose of 1.6 mg/kg bw during 10 days. Concentrations were measured on edible tissue on different days post‐treatment. A linear regression of the time vs. concentration was conducted, obtaining a withdrawal time of 1966 °C days. Results obtained reveal that the dose of 1.6 mg/kg bw orally administered is effective for ISA virus, originating a reasonable withdrawal period within the productive schedules of Atlantic salmon.