Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus‐2 pandemic in Turkey: A single‐centre experience
Aim Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection may result in a life‐threatening hyperinflammatory condition named multisystem inflammatory syndrome in children (MIS‐C). We aimed to assess demographics, clinical presentations, laboratory characteristics and treatment outco...
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crwiley:10.1111/jpc.15674 2024-06-23T07:56:34+00:00 Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus‐2 pandemic in Turkey: A single‐centre experience Savas Sen, Zeynep Tanir, Gonul Gumuser Cinni, Ruveyda Uysal Yazici, Mutlu Yoldas, Tamer Ozturk, Zeynelabidin Kizilkaya, Mete Han Ozdem, Suna Yalcinkaya, Rumeysa Ozturk, Caner Yuce Sezen, Aslihan Ozdel, Semanur Derinkuyu, Betul Emine Polat, Meltem Oz, Fatma Nur 2021 http://dx.doi.org/10.1111/jpc.15674 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jpc.15674 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jpc.15674 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Paediatrics and Child Health volume 58, issue 1, page 129-135 ISSN 1034-4810 1440-1754 journal-article 2021 crwiley https://doi.org/10.1111/jpc.15674 2024-06-06T04:22:34Z Aim Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection may result in a life‐threatening hyperinflammatory condition named multisystem inflammatory syndrome in children (MIS‐C). We aimed to assess demographics, clinical presentations, laboratory characteristics and treatment outcomes of patients with MIS‐C. Methods We performed a retrospective study of patients with MIS‐C managed between August 2020 and March 2021 at Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital in Turkey. Results A total of 45 patients (23 male, 51%) with a median age of 8.7 years (interquartile range: 5.6–11.7 years) were enrolled to study. The SARS‐CoV‐2 serology was positive in 43 (95%) patients. Organ‐system involvement included the dermatologic in 41 (91%), cardiovascular in 39 (87%), hematologic in 36 (80%) and gastrointestinal in 36 (80%) patients. Acute anterior uveitis was diagnosed in nine (20%) patients. Two patients presented with clinical findings of deep neck infection such as fever, neck pain, trismus, swelling and induration on the cervical lymph node. One patient presented with Henoch–Schonlein purpura‐like eruption. Coronary artery dilatation was detected in five (11%) patients. For treatment of MIS‐C, intravenous immunoglobulin was used in 44 (98%) patients, methylprednisolone in 27 (60%) and anakinra in 9 (20%) patients. The median duration of hospitalisation was nine days. All patients recovered. Conclusions Children with MIS‐C might have variable clinical presentations. Acute anterior uveitis might be a prominent presentation of MIS‐C and require ophthalmological examination. It is essential to make patient‐based decisions and apply a stepwise approach for the treatment of this life‐threatening disease. Article in Journal/Newspaper sami Wiley Online Library Journal of Paediatrics and Child Health 58 1 129 135 |
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Aim Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection may result in a life‐threatening hyperinflammatory condition named multisystem inflammatory syndrome in children (MIS‐C). We aimed to assess demographics, clinical presentations, laboratory characteristics and treatment outcomes of patients with MIS‐C. Methods We performed a retrospective study of patients with MIS‐C managed between August 2020 and March 2021 at Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital in Turkey. Results A total of 45 patients (23 male, 51%) with a median age of 8.7 years (interquartile range: 5.6–11.7 years) were enrolled to study. The SARS‐CoV‐2 serology was positive in 43 (95%) patients. Organ‐system involvement included the dermatologic in 41 (91%), cardiovascular in 39 (87%), hematologic in 36 (80%) and gastrointestinal in 36 (80%) patients. Acute anterior uveitis was diagnosed in nine (20%) patients. Two patients presented with clinical findings of deep neck infection such as fever, neck pain, trismus, swelling and induration on the cervical lymph node. One patient presented with Henoch–Schonlein purpura‐like eruption. Coronary artery dilatation was detected in five (11%) patients. For treatment of MIS‐C, intravenous immunoglobulin was used in 44 (98%) patients, methylprednisolone in 27 (60%) and anakinra in 9 (20%) patients. The median duration of hospitalisation was nine days. All patients recovered. Conclusions Children with MIS‐C might have variable clinical presentations. Acute anterior uveitis might be a prominent presentation of MIS‐C and require ophthalmological examination. It is essential to make patient‐based decisions and apply a stepwise approach for the treatment of this life‐threatening disease. |
format |
Article in Journal/Newspaper |
author |
Savas Sen, Zeynep Tanir, Gonul Gumuser Cinni, Ruveyda Uysal Yazici, Mutlu Yoldas, Tamer Ozturk, Zeynelabidin Kizilkaya, Mete Han Ozdem, Suna Yalcinkaya, Rumeysa Ozturk, Caner Yuce Sezen, Aslihan Ozdel, Semanur Derinkuyu, Betul Emine Polat, Meltem Oz, Fatma Nur |
spellingShingle |
Savas Sen, Zeynep Tanir, Gonul Gumuser Cinni, Ruveyda Uysal Yazici, Mutlu Yoldas, Tamer Ozturk, Zeynelabidin Kizilkaya, Mete Han Ozdem, Suna Yalcinkaya, Rumeysa Ozturk, Caner Yuce Sezen, Aslihan Ozdel, Semanur Derinkuyu, Betul Emine Polat, Meltem Oz, Fatma Nur Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus‐2 pandemic in Turkey: A single‐centre experience |
author_facet |
Savas Sen, Zeynep Tanir, Gonul Gumuser Cinni, Ruveyda Uysal Yazici, Mutlu Yoldas, Tamer Ozturk, Zeynelabidin Kizilkaya, Mete Han Ozdem, Suna Yalcinkaya, Rumeysa Ozturk, Caner Yuce Sezen, Aslihan Ozdel, Semanur Derinkuyu, Betul Emine Polat, Meltem Oz, Fatma Nur |
author_sort |
Savas Sen, Zeynep |
title |
Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus‐2 pandemic in Turkey: A single‐centre experience |
title_short |
Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus‐2 pandemic in Turkey: A single‐centre experience |
title_full |
Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus‐2 pandemic in Turkey: A single‐centre experience |
title_fullStr |
Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus‐2 pandemic in Turkey: A single‐centre experience |
title_full_unstemmed |
Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus‐2 pandemic in Turkey: A single‐centre experience |
title_sort |
multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus‐2 pandemic in turkey: a single‐centre experience |
publisher |
Wiley |
publishDate |
2021 |
url |
http://dx.doi.org/10.1111/jpc.15674 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jpc.15674 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jpc.15674 |
genre |
sami |
genre_facet |
sami |
op_source |
Journal of Paediatrics and Child Health volume 58, issue 1, page 129-135 ISSN 1034-4810 1440-1754 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/jpc.15674 |
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Journal of Paediatrics and Child Health |
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58 |
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1 |
container_start_page |
129 |
op_container_end_page |
135 |
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1802649752973606912 |