Diabetes, prediabetes, and atrial fibrillation—A population‐based cohort study based on national and regional registers
Abstract Background Previous studies have shown an increased risk for atrial fibrillation and atrial flutter (AF) in people with type 2 diabetes and prediabetes. It is unclear whether this increase in AF risk is independent of other risk factors for AF. Objective To investigate the association betwe...
Published in: | Journal of Internal Medicine |
---|---|
Main Authors: | , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2023
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1111/joim.13688 https://onlinelibrary.wiley.com/doi/pdf/10.1111/joim.13688 |
id |
crwiley:10.1111/joim.13688 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1111/joim.13688 2023-12-03T10:27:58+01:00 Diabetes, prediabetes, and atrial fibrillation—A population‐based cohort study based on national and regional registers Johansson, Cecilia Örtendahl, Lina Lind, Marcus M. Andersson, Jonas Johansson, Lars Brunström, Mattias Umeå Universitet 2023 http://dx.doi.org/10.1111/joim.13688 https://onlinelibrary.wiley.com/doi/pdf/10.1111/joim.13688 en eng Wiley http://creativecommons.org/licenses/by/4.0/ Journal of Internal Medicine volume 294, issue 5, page 605-615 ISSN 0954-6820 1365-2796 Internal Medicine journal-article 2023 crwiley https://doi.org/10.1111/joim.13688 2023-11-09T13:44:19Z Abstract Background Previous studies have shown an increased risk for atrial fibrillation and atrial flutter (AF) in people with type 2 diabetes and prediabetes. It is unclear whether this increase in AF risk is independent of other risk factors for AF. Objective To investigate the association between diabetes and different prediabetic states, as independent risk factors for the onset of AF. Methods We performed a population‐based cohort study in Northern Sweden, including data on fasting plasma glucose, oral glucose tolerance test, major cardiovascular risk factors, medical history, and lifestyle factors. Participants were divided into six groups depending on glycemic status and followed through national registers for AF diagnosis. Cox proportional hazard model was used to assess the association between glycemic status and AF, using normoglycemia as reference. Results The cohort consisted of 88,889 participants who underwent a total of 139,661 health examinations. In the model adjusted for age and sex, there was a significant association between glycemic status and development of AF in all groups except the impaired glucose tolerance group, with the strongest association for the group with known diabetes ( p ‐value <0.001). In a model adjusted for sex, age, systolic blood pressure, body mass index, antihypertensive drugs, cholesterol, alcohol, smoking, education level, marital status, and physical activity, there was no significant association between glycemic status and AF. Conclusions/interpretation The association between glycemic status and AF disappears upon adjustment for potential confounders. Diabetes and prediabetes do not appear to be independent risk factors for AF. Article in Journal/Newspaper Northern Sweden Wiley Online Library (via Crossref) Journal of Internal Medicine 294 5 605 615 |
institution |
Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Internal Medicine |
spellingShingle |
Internal Medicine Johansson, Cecilia Örtendahl, Lina Lind, Marcus M. Andersson, Jonas Johansson, Lars Brunström, Mattias Diabetes, prediabetes, and atrial fibrillation—A population‐based cohort study based on national and regional registers |
topic_facet |
Internal Medicine |
description |
Abstract Background Previous studies have shown an increased risk for atrial fibrillation and atrial flutter (AF) in people with type 2 diabetes and prediabetes. It is unclear whether this increase in AF risk is independent of other risk factors for AF. Objective To investigate the association between diabetes and different prediabetic states, as independent risk factors for the onset of AF. Methods We performed a population‐based cohort study in Northern Sweden, including data on fasting plasma glucose, oral glucose tolerance test, major cardiovascular risk factors, medical history, and lifestyle factors. Participants were divided into six groups depending on glycemic status and followed through national registers for AF diagnosis. Cox proportional hazard model was used to assess the association between glycemic status and AF, using normoglycemia as reference. Results The cohort consisted of 88,889 participants who underwent a total of 139,661 health examinations. In the model adjusted for age and sex, there was a significant association between glycemic status and development of AF in all groups except the impaired glucose tolerance group, with the strongest association for the group with known diabetes ( p ‐value <0.001). In a model adjusted for sex, age, systolic blood pressure, body mass index, antihypertensive drugs, cholesterol, alcohol, smoking, education level, marital status, and physical activity, there was no significant association between glycemic status and AF. Conclusions/interpretation The association between glycemic status and AF disappears upon adjustment for potential confounders. Diabetes and prediabetes do not appear to be independent risk factors for AF. |
author2 |
Umeå Universitet |
format |
Article in Journal/Newspaper |
author |
Johansson, Cecilia Örtendahl, Lina Lind, Marcus M. Andersson, Jonas Johansson, Lars Brunström, Mattias |
author_facet |
Johansson, Cecilia Örtendahl, Lina Lind, Marcus M. Andersson, Jonas Johansson, Lars Brunström, Mattias |
author_sort |
Johansson, Cecilia |
title |
Diabetes, prediabetes, and atrial fibrillation—A population‐based cohort study based on national and regional registers |
title_short |
Diabetes, prediabetes, and atrial fibrillation—A population‐based cohort study based on national and regional registers |
title_full |
Diabetes, prediabetes, and atrial fibrillation—A population‐based cohort study based on national and regional registers |
title_fullStr |
Diabetes, prediabetes, and atrial fibrillation—A population‐based cohort study based on national and regional registers |
title_full_unstemmed |
Diabetes, prediabetes, and atrial fibrillation—A population‐based cohort study based on national and regional registers |
title_sort |
diabetes, prediabetes, and atrial fibrillation—a population‐based cohort study based on national and regional registers |
publisher |
Wiley |
publishDate |
2023 |
url |
http://dx.doi.org/10.1111/joim.13688 https://onlinelibrary.wiley.com/doi/pdf/10.1111/joim.13688 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Journal of Internal Medicine volume 294, issue 5, page 605-615 ISSN 0954-6820 1365-2796 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1111/joim.13688 |
container_title |
Journal of Internal Medicine |
container_volume |
294 |
container_issue |
5 |
container_start_page |
605 |
op_container_end_page |
615 |
_version_ |
1784277935353495552 |