Laterality defect of the heart in non‐teleost fish
Abstract Dextrocardia is a rare congenital malformation in humans in which most of the heart mass is positioned in the right hemithorax rather than on the left. The heart itself may be normal and dextrocardia is sometimes diagnosed during non‐related explorations. A few reports have documented atypi...
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crwiley:10.1111/joa.13933 2024-05-19T07:50:11+00:00 Laterality defect of the heart in non‐teleost fish Huijskes, Myrte M. Icardo, José M. Coolen, Bram F. Jensen, Bjarke 2023 http://dx.doi.org/10.1111/joa.13933 https://onlinelibrary.wiley.com/doi/pdf/10.1111/joa.13933 en eng Wiley http://creativecommons.org/licenses/by-nc/4.0/ Journal of Anatomy volume 243, issue 6, page 1052-1058 ISSN 0021-8782 1469-7580 journal-article 2023 crwiley https://doi.org/10.1111/joa.13933 2024-04-25T08:30:33Z Abstract Dextrocardia is a rare congenital malformation in humans in which most of the heart mass is positioned in the right hemithorax rather than on the left. The heart itself may be normal and dextrocardia is sometimes diagnosed during non‐related explorations. A few reports have documented atypical positions of the cardiac chambers in farmed teleost fish. Here, we report the casual finding of a left–right mirrored heart in an 85 cm long wild‐caught spiny dogfish ( Squalus acanthias ) with several organ malformations. Macroscopic observations showed an outflow tract originating from the left side of the ventricular mass, rather than from the right. Internal inspection revealed the expected structures and a looped cavity. The inner curvature of the loop comprised a large trabeculation, the bulboventricular fold, as expected. The junction between the sinus venosus and the atrium appeared normal, only mirrored. MRI data acquired at 0.7 mm isotropic resolution and subsequent 3D‐modeling revealed the atrioventricular canal was to the right of the bulboventricular fold, rather than on the left. Spurred by the finding of dextrocardia in the shark, we revisit our previously published material on farmed Adriatic sturgeon ( Acipenser naccarii ), a non‐teleost bony fish. We found several alevins with inverted (left‐loop) hearts, amounting to an approximate incidence of 1%–2%. Additionally, an adult sturgeon measuring 90 cm in length showed abnormal topology of the cardiac chambers, but normal position of the abdominal organs. In conclusion, left–right mirrored hearts, a setting that resembles human dextrocardia, can occur in both farmed and wild non‐teleost fish. Article in Journal/Newspaper spiny dogfish Squalus acanthias Wiley Online Library |
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Wiley Online Library |
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English |
description |
Abstract Dextrocardia is a rare congenital malformation in humans in which most of the heart mass is positioned in the right hemithorax rather than on the left. The heart itself may be normal and dextrocardia is sometimes diagnosed during non‐related explorations. A few reports have documented atypical positions of the cardiac chambers in farmed teleost fish. Here, we report the casual finding of a left–right mirrored heart in an 85 cm long wild‐caught spiny dogfish ( Squalus acanthias ) with several organ malformations. Macroscopic observations showed an outflow tract originating from the left side of the ventricular mass, rather than from the right. Internal inspection revealed the expected structures and a looped cavity. The inner curvature of the loop comprised a large trabeculation, the bulboventricular fold, as expected. The junction between the sinus venosus and the atrium appeared normal, only mirrored. MRI data acquired at 0.7 mm isotropic resolution and subsequent 3D‐modeling revealed the atrioventricular canal was to the right of the bulboventricular fold, rather than on the left. Spurred by the finding of dextrocardia in the shark, we revisit our previously published material on farmed Adriatic sturgeon ( Acipenser naccarii ), a non‐teleost bony fish. We found several alevins with inverted (left‐loop) hearts, amounting to an approximate incidence of 1%–2%. Additionally, an adult sturgeon measuring 90 cm in length showed abnormal topology of the cardiac chambers, but normal position of the abdominal organs. In conclusion, left–right mirrored hearts, a setting that resembles human dextrocardia, can occur in both farmed and wild non‐teleost fish. |
format |
Article in Journal/Newspaper |
author |
Huijskes, Myrte M. Icardo, José M. Coolen, Bram F. Jensen, Bjarke |
spellingShingle |
Huijskes, Myrte M. Icardo, José M. Coolen, Bram F. Jensen, Bjarke Laterality defect of the heart in non‐teleost fish |
author_facet |
Huijskes, Myrte M. Icardo, José M. Coolen, Bram F. Jensen, Bjarke |
author_sort |
Huijskes, Myrte M. |
title |
Laterality defect of the heart in non‐teleost fish |
title_short |
Laterality defect of the heart in non‐teleost fish |
title_full |
Laterality defect of the heart in non‐teleost fish |
title_fullStr |
Laterality defect of the heart in non‐teleost fish |
title_full_unstemmed |
Laterality defect of the heart in non‐teleost fish |
title_sort |
laterality defect of the heart in non‐teleost fish |
publisher |
Wiley |
publishDate |
2023 |
url |
http://dx.doi.org/10.1111/joa.13933 https://onlinelibrary.wiley.com/doi/pdf/10.1111/joa.13933 |
genre |
spiny dogfish Squalus acanthias |
genre_facet |
spiny dogfish Squalus acanthias |
op_source |
Journal of Anatomy volume 243, issue 6, page 1052-1058 ISSN 0021-8782 1469-7580 |
op_rights |
http://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1111/joa.13933 |
_version_ |
1799468775733460992 |