Transcriptome analysis of turbot ( Scophthalmus maximus) head kidney and liver reveals immune mechanism in response to Vibrio anguillarum infection
Abstract The diseases triggered by Vibrio anguillarum infection have created huge economic losses to the turbot ( Scophthalmus maximus ) farming industry. However, the immune mechanism of turbot to V. anguillarum infection has not been deeply investigated. To better understand the immune response of...
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Online Access: | http://dx.doi.org/10.1111/jfd.13628 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.13628 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jfd.13628 |
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crwiley:10.1111/jfd.13628 2024-06-23T07:56:36+00:00 Transcriptome analysis of turbot ( Scophthalmus maximus) head kidney and liver reveals immune mechanism in response to Vibrio anguillarum infection Song, Yuting Dong, Xianzhi Hu, Guobin Fundamental Research Funds for the Central Universities Natural Science Foundation of Shandong Province 2022 http://dx.doi.org/10.1111/jfd.13628 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.13628 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jfd.13628 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Fish Diseases volume 45, issue 7, page 1045-1057 ISSN 0140-7775 1365-2761 journal-article 2022 crwiley https://doi.org/10.1111/jfd.13628 2024-05-31T08:13:49Z Abstract The diseases triggered by Vibrio anguillarum infection have created huge economic losses to the turbot ( Scophthalmus maximus ) farming industry. However, the immune mechanism of turbot to V. anguillarum infection has not been deeply investigated. To better understand the immune response of turbot to V. anguillarum infection, transcriptome analysis of the head kidney and liver of turbot was performed. A total of 15,948 and 11,494 differentially expressed genes (DEGs) were obtained from the turbot head kidney and liver, respectively. Transcriptome analysis revealed that the head kidney and liver of turbot have some differences in the gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the DEGs for the different functions of these two organs. Although there are many uncertain factors in this immune process, such as the occurrence of alternative splicing (AS) events and the differences in the protein structure of the DEGs, the NFκB signalling pathway, MKK‐dependent AP‐1 activation, JAK‐STAT signalling pathway, the signal transmission of MHC Ⅰ and a series of DEGs including HSP90 driving NLRP3 to produce inflammatory factors (IL‐1β, IL‐8, TNFα, etc.) were possible important immune response pathways for turbot to V. anguillarum infection. Overall, our research has conducted a preliminary exploration of the immune mechanism of turbot in response to V. anguillarum infection. Article in Journal/Newspaper Scophthalmus maximus Turbot Wiley Online Library Journal of Fish Diseases 45 7 1045 1057 |
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Wiley Online Library |
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English |
description |
Abstract The diseases triggered by Vibrio anguillarum infection have created huge economic losses to the turbot ( Scophthalmus maximus ) farming industry. However, the immune mechanism of turbot to V. anguillarum infection has not been deeply investigated. To better understand the immune response of turbot to V. anguillarum infection, transcriptome analysis of the head kidney and liver of turbot was performed. A total of 15,948 and 11,494 differentially expressed genes (DEGs) were obtained from the turbot head kidney and liver, respectively. Transcriptome analysis revealed that the head kidney and liver of turbot have some differences in the gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the DEGs for the different functions of these two organs. Although there are many uncertain factors in this immune process, such as the occurrence of alternative splicing (AS) events and the differences in the protein structure of the DEGs, the NFκB signalling pathway, MKK‐dependent AP‐1 activation, JAK‐STAT signalling pathway, the signal transmission of MHC Ⅰ and a series of DEGs including HSP90 driving NLRP3 to produce inflammatory factors (IL‐1β, IL‐8, TNFα, etc.) were possible important immune response pathways for turbot to V. anguillarum infection. Overall, our research has conducted a preliminary exploration of the immune mechanism of turbot in response to V. anguillarum infection. |
author2 |
Fundamental Research Funds for the Central Universities Natural Science Foundation of Shandong Province |
format |
Article in Journal/Newspaper |
author |
Song, Yuting Dong, Xianzhi Hu, Guobin |
spellingShingle |
Song, Yuting Dong, Xianzhi Hu, Guobin Transcriptome analysis of turbot ( Scophthalmus maximus) head kidney and liver reveals immune mechanism in response to Vibrio anguillarum infection |
author_facet |
Song, Yuting Dong, Xianzhi Hu, Guobin |
author_sort |
Song, Yuting |
title |
Transcriptome analysis of turbot ( Scophthalmus maximus) head kidney and liver reveals immune mechanism in response to Vibrio anguillarum infection |
title_short |
Transcriptome analysis of turbot ( Scophthalmus maximus) head kidney and liver reveals immune mechanism in response to Vibrio anguillarum infection |
title_full |
Transcriptome analysis of turbot ( Scophthalmus maximus) head kidney and liver reveals immune mechanism in response to Vibrio anguillarum infection |
title_fullStr |
Transcriptome analysis of turbot ( Scophthalmus maximus) head kidney and liver reveals immune mechanism in response to Vibrio anguillarum infection |
title_full_unstemmed |
Transcriptome analysis of turbot ( Scophthalmus maximus) head kidney and liver reveals immune mechanism in response to Vibrio anguillarum infection |
title_sort |
transcriptome analysis of turbot ( scophthalmus maximus) head kidney and liver reveals immune mechanism in response to vibrio anguillarum infection |
publisher |
Wiley |
publishDate |
2022 |
url |
http://dx.doi.org/10.1111/jfd.13628 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.13628 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jfd.13628 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
Journal of Fish Diseases volume 45, issue 7, page 1045-1057 ISSN 0140-7775 1365-2761 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/jfd.13628 |
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Journal of Fish Diseases |
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45 |
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7 |
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1045 |
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1057 |
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1802649862383075328 |