Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV)
Abstract Melanized focal changes in skeletal muscle of farmed Atlantic salmon ( Salmo salar ) are a major quality problem. The aetiology is unknown, but infection with Piscine orthoreovirus (PRV) has been associated with the condition. Here, we addressed the pathogenesis of red and melanized focal c...
Published in: | Journal of Fish Diseases |
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Online Access: | http://dx.doi.org/10.1111/jfd.12995 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12995 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12995 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jfd.12995 |
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crwiley:10.1111/jfd.12995 2024-09-30T14:32:26+00:00 Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV) Bjørgen, Håvard Haldorsen, Randi Oaland, Øyvind Kvellestad, Agnar Kannimuthu, Dhamotharan Rimstad, Espen Koppang, Erling Olaf Fiskeri - og havbruksnæringens forskningsfond 2019 http://dx.doi.org/10.1111/jfd.12995 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12995 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12995 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jfd.12995 en eng Wiley http://creativecommons.org/licenses/by/4.0/ Journal of Fish Diseases volume 42, issue 6, page 935-945 ISSN 0140-7775 1365-2761 journal-article 2019 crwiley https://doi.org/10.1111/jfd.12995 2024-09-17T04:46:39Z Abstract Melanized focal changes in skeletal muscle of farmed Atlantic salmon ( Salmo salar ) are a major quality problem. The aetiology is unknown, but infection with Piscine orthoreovirus (PRV) has been associated with the condition. Here, we addressed the pathogenesis of red and melanized focal changes and their association with PRV. First, a population of farmed fish (PRV‐negative prior to sea transfer) was sequentially investigated throughout the seawater period. The fish were autopsied and tested for PRV infection. Muscular changes were described by macroscopy and histology, and a classification system was established. Second, in an experimental infection trial, PRV was injected intramuscularly to induce changes. The farmed fish was gradually infected with PRV. Red focal changes occurred throughout the observation period with a low prevalence regardless of PRV status. Melanized changes were highly diverse and their prevalence increased during the trial. Changes of low macroscopic grade and histological category were more prevalent in PRV‐negative fish. Diffuse granulomatous melanized changes only occurred after PRV infection. No muscular changes were observed in the experimentally challenged fish. Our studies do not indicate that PRV infection causes red focal changes, but seems important in the development of granulomatous melanized changes. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library Journal of Fish Diseases 42 6 935 945 |
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English |
description |
Abstract Melanized focal changes in skeletal muscle of farmed Atlantic salmon ( Salmo salar ) are a major quality problem. The aetiology is unknown, but infection with Piscine orthoreovirus (PRV) has been associated with the condition. Here, we addressed the pathogenesis of red and melanized focal changes and their association with PRV. First, a population of farmed fish (PRV‐negative prior to sea transfer) was sequentially investigated throughout the seawater period. The fish were autopsied and tested for PRV infection. Muscular changes were described by macroscopy and histology, and a classification system was established. Second, in an experimental infection trial, PRV was injected intramuscularly to induce changes. The farmed fish was gradually infected with PRV. Red focal changes occurred throughout the observation period with a low prevalence regardless of PRV status. Melanized changes were highly diverse and their prevalence increased during the trial. Changes of low macroscopic grade and histological category were more prevalent in PRV‐negative fish. Diffuse granulomatous melanized changes only occurred after PRV infection. No muscular changes were observed in the experimentally challenged fish. Our studies do not indicate that PRV infection causes red focal changes, but seems important in the development of granulomatous melanized changes. |
author2 |
Fiskeri - og havbruksnæringens forskningsfond |
format |
Article in Journal/Newspaper |
author |
Bjørgen, Håvard Haldorsen, Randi Oaland, Øyvind Kvellestad, Agnar Kannimuthu, Dhamotharan Rimstad, Espen Koppang, Erling Olaf |
spellingShingle |
Bjørgen, Håvard Haldorsen, Randi Oaland, Øyvind Kvellestad, Agnar Kannimuthu, Dhamotharan Rimstad, Espen Koppang, Erling Olaf Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV) |
author_facet |
Bjørgen, Håvard Haldorsen, Randi Oaland, Øyvind Kvellestad, Agnar Kannimuthu, Dhamotharan Rimstad, Espen Koppang, Erling Olaf |
author_sort |
Bjørgen, Håvard |
title |
Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV) |
title_short |
Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV) |
title_full |
Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV) |
title_fullStr |
Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV) |
title_full_unstemmed |
Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV) |
title_sort |
melanized focal changes in skeletal muscle in farmed atlantic salmon after natural infection with piscine orthoreovirus (prv) |
publisher |
Wiley |
publishDate |
2019 |
url |
http://dx.doi.org/10.1111/jfd.12995 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12995 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12995 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jfd.12995 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Fish Diseases volume 42, issue 6, page 935-945 ISSN 0140-7775 1365-2761 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1111/jfd.12995 |
container_title |
Journal of Fish Diseases |
container_volume |
42 |
container_issue |
6 |
container_start_page |
935 |
op_container_end_page |
945 |
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1811636595505233920 |