A screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice Lepeophtheirus salmonis
Abstract The salmon louse, Lepeophtheirus salmonis Krøyer, is the major obstacle facing a sustainable future for farmers of salmonids in the North Atlantic Ocean. Medicinal compounds have been the most utilized tool to prevent salmon lice infestation; however, the active compounds have become less e...
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Online Access: | http://dx.doi.org/10.1111/jfd.12463 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12463 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12463 |
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crwiley:10.1111/jfd.12463 2024-06-23T07:55:07+00:00 A screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice Lepeophtheirus salmonis Aaen, S M Horsberg, T E 2016 http://dx.doi.org/10.1111/jfd.12463 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12463 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12463 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Fish Diseases volume 39, issue 10, page 1213-1223 ISSN 0140-7775 1365-2761 journal-article 2016 crwiley https://doi.org/10.1111/jfd.12463 2024-06-06T04:20:43Z Abstract The salmon louse, Lepeophtheirus salmonis Krøyer, is the major obstacle facing a sustainable future for farmers of salmonids in the North Atlantic Ocean. Medicinal compounds have been the most utilized tool to prevent salmon lice infestation; however, the active compounds have become less effective or considered environmentally unfriendly in the past years. Novel medicinal compounds are thus highly desired. In two experiment series, 26 medicinal compounds were screened for their efficacy against salmon lice, in a 30‐min exposure and 24‐h exposure, respectively. Pyriprole, imidacloprid, cartap and spinetoram were effective at 50 mg L −1 in the short‐time exposure. In the 24‐h exposure, pyriprole, propoxur, cartap, imidacloprid, fenoxycarb, pyriproxyfen, nitenpyram, spinetoram, spiromesifen and diflubenzuron induced a high level of immobilization at 5 mg L −1 . The EC 50 values of the effective compounds were calculated in further titration studies for both exposure periods. Several physiological and biochemical pathways were discovered as possible targets for medicinal intervention against the salmon louse. Article in Journal/Newspaper North Atlantic Wiley Online Library Journal of Fish Diseases 39 10 1213 1223 |
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Open Polar |
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Wiley Online Library |
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language |
English |
description |
Abstract The salmon louse, Lepeophtheirus salmonis Krøyer, is the major obstacle facing a sustainable future for farmers of salmonids in the North Atlantic Ocean. Medicinal compounds have been the most utilized tool to prevent salmon lice infestation; however, the active compounds have become less effective or considered environmentally unfriendly in the past years. Novel medicinal compounds are thus highly desired. In two experiment series, 26 medicinal compounds were screened for their efficacy against salmon lice, in a 30‐min exposure and 24‐h exposure, respectively. Pyriprole, imidacloprid, cartap and spinetoram were effective at 50 mg L −1 in the short‐time exposure. In the 24‐h exposure, pyriprole, propoxur, cartap, imidacloprid, fenoxycarb, pyriproxyfen, nitenpyram, spinetoram, spiromesifen and diflubenzuron induced a high level of immobilization at 5 mg L −1 . The EC 50 values of the effective compounds were calculated in further titration studies for both exposure periods. Several physiological and biochemical pathways were discovered as possible targets for medicinal intervention against the salmon louse. |
format |
Article in Journal/Newspaper |
author |
Aaen, S M Horsberg, T E |
spellingShingle |
Aaen, S M Horsberg, T E A screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice Lepeophtheirus salmonis |
author_facet |
Aaen, S M Horsberg, T E |
author_sort |
Aaen, S M |
title |
A screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice Lepeophtheirus salmonis |
title_short |
A screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice Lepeophtheirus salmonis |
title_full |
A screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice Lepeophtheirus salmonis |
title_fullStr |
A screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice Lepeophtheirus salmonis |
title_full_unstemmed |
A screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice Lepeophtheirus salmonis |
title_sort |
screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice lepeophtheirus salmonis |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1111/jfd.12463 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12463 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12463 |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_source |
Journal of Fish Diseases volume 39, issue 10, page 1213-1223 ISSN 0140-7775 1365-2761 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/jfd.12463 |
container_title |
Journal of Fish Diseases |
container_volume |
39 |
container_issue |
10 |
container_start_page |
1213 |
op_container_end_page |
1223 |
_version_ |
1802647560034189312 |