Host tropism of infectious salmon anaemia virus in marine and freshwater fish species
Abstract The aquatic orthomyxovirus infectious salmon anaemia virus ( ISAV ) causes a severe disease in farmed Atlantic salmon, Salmo salar L. Although some ISA outbreaks are caused by horizontal transmission of virus between farms, the source and reservoir of the virus is largely unknown and a wild...
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crwiley:10.1111/jfd.12284 2024-09-15T17:56:10+00:00 Host tropism of infectious salmon anaemia virus in marine and freshwater fish species Aamelfot, M Dale, O B McBeath, A Falk, K Atlantic Innovation Fund, Canada Inc. Novartis Animal Health 2014 http://dx.doi.org/10.1111/jfd.12284 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12284 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12284 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Fish Diseases volume 38, issue 8, page 687-694 ISSN 0140-7775 1365-2761 journal-article 2014 crwiley https://doi.org/10.1111/jfd.12284 2024-08-22T04:17:07Z Abstract The aquatic orthomyxovirus infectious salmon anaemia virus ( ISAV ) causes a severe disease in farmed Atlantic salmon, Salmo salar L. Although some ISA outbreaks are caused by horizontal transmission of virus between farms, the source and reservoir of the virus is largely unknown and a wild host has been hypothesized. Atlantic salmon are farmed in open net‐pens, allowing transmission of pathogens from wild fish and the surrounding environment to the farmed fish. In this study, a large number of fish species were investigated for ISAV host potential. For orthomyxoviruses, a specific receptor binding is the first requirement for infection; thus, the fish species were investigated for the presence of the ISAV receptor. The receptor was found to be widely distributed across the fish species. All salmonids expressed the receptor. However, only some of the cod‐like and perch‐like fish did, and all flat fish were negative. In the majority of the positive species, the receptor was found on endothelial cells and/or on red blood cells. The study forms a basis for further investigations and opens up the possibility for screening species to determine whether a wild host of ISAV exists. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library Journal of Fish Diseases 38 8 687 694 |
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Wiley Online Library |
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English |
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Abstract The aquatic orthomyxovirus infectious salmon anaemia virus ( ISAV ) causes a severe disease in farmed Atlantic salmon, Salmo salar L. Although some ISA outbreaks are caused by horizontal transmission of virus between farms, the source and reservoir of the virus is largely unknown and a wild host has been hypothesized. Atlantic salmon are farmed in open net‐pens, allowing transmission of pathogens from wild fish and the surrounding environment to the farmed fish. In this study, a large number of fish species were investigated for ISAV host potential. For orthomyxoviruses, a specific receptor binding is the first requirement for infection; thus, the fish species were investigated for the presence of the ISAV receptor. The receptor was found to be widely distributed across the fish species. All salmonids expressed the receptor. However, only some of the cod‐like and perch‐like fish did, and all flat fish were negative. In the majority of the positive species, the receptor was found on endothelial cells and/or on red blood cells. The study forms a basis for further investigations and opens up the possibility for screening species to determine whether a wild host of ISAV exists. |
author2 |
Atlantic Innovation Fund, Canada Inc. Novartis Animal Health |
format |
Article in Journal/Newspaper |
author |
Aamelfot, M Dale, O B McBeath, A Falk, K |
spellingShingle |
Aamelfot, M Dale, O B McBeath, A Falk, K Host tropism of infectious salmon anaemia virus in marine and freshwater fish species |
author_facet |
Aamelfot, M Dale, O B McBeath, A Falk, K |
author_sort |
Aamelfot, M |
title |
Host tropism of infectious salmon anaemia virus in marine and freshwater fish species |
title_short |
Host tropism of infectious salmon anaemia virus in marine and freshwater fish species |
title_full |
Host tropism of infectious salmon anaemia virus in marine and freshwater fish species |
title_fullStr |
Host tropism of infectious salmon anaemia virus in marine and freshwater fish species |
title_full_unstemmed |
Host tropism of infectious salmon anaemia virus in marine and freshwater fish species |
title_sort |
host tropism of infectious salmon anaemia virus in marine and freshwater fish species |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1111/jfd.12284 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12284 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12284 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Fish Diseases volume 38, issue 8, page 687-694 ISSN 0140-7775 1365-2761 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/jfd.12284 |
container_title |
Journal of Fish Diseases |
container_volume |
38 |
container_issue |
8 |
container_start_page |
687 |
op_container_end_page |
694 |
_version_ |
1810432379826733056 |