Combinatorial effects of administration of immunostimulatory compounds in feed and follow‐up administration of triple‐dose <scp>SLICE</scp> ® (<scp>e</scp>mamectin benzoate) on <scp>A</scp>tlantic salmon, <scp>S</scp>almo salar L., infection with <scp>L</scp>epeophtheirus salmonis
Abstract Several immunostimulatory feed additives have shown the ability to induce protective responses in A tlantic salmon to infection with L epeophtheirus salmonis . However, even the most encouraging results rarely surpass a 50% protective index in the host. That fact coupled with the well‐docum...
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Online Access: | http://dx.doi.org/10.1111/jfd.12062 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12062 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12062 |
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crwiley:10.1111/jfd.12062 2023-12-03T10:19:45+01:00 Combinatorial effects of administration of immunostimulatory compounds in feed and follow‐up administration of triple‐dose <scp>SLICE</scp> ® (<scp>e</scp>mamectin benzoate) on <scp>A</scp>tlantic salmon, <scp>S</scp>almo salar L., infection with <scp>L</scp>epeophtheirus salmonis Poley, J Purcell, S L Igboeli, O O Donkin, A Wotton, H Fast, M D NSERC engage programme Springboard Atlantic Northeast Nutrition and Cooke Aquaculture Ltd. Aquatic Animal Facilities and staff at AVC-UPEI 2013 http://dx.doi.org/10.1111/jfd.12062 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12062 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12062 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Fish Diseases volume 36, issue 3, page 299-309 ISSN 0140-7775 1365-2761 Veterinary (miscellaneous) Aquatic Science journal-article 2013 crwiley https://doi.org/10.1111/jfd.12062 2023-11-09T14:29:56Z Abstract Several immunostimulatory feed additives have shown the ability to induce protective responses in A tlantic salmon to infection with L epeophtheirus salmonis . However, even the most encouraging results rarely surpass a 50% protective index in the host. That fact coupled with the well‐documented limitations of single‐therapy strategies in the effective management of parasitic infections generally make it imperative to identify therapies that can be combined in an integrated pest management approach for sea lice. With this in mind, we hypothesized that immunostimulatory feeds could enhance the protection provided by SLICE ® emamectin benzoate ( EMB ). To test this hypothesis, Atlantic salmon were fed one of two different immunostimulatory feeds ( CpG ODN or A quate ® ) for c . 7 weeks, challenged with L . salmonis copepodids early within that immunostimulatory feed period and then placed on a triple‐dose (150 μg kg −1 ) feed of SLICE ® for 1 week following the completion of the immunostimulatory feeding period. CpG ODN (2 mg kg −1 ) and the commercial yeast extract ( A quate ® 0.2%) inclusion in feeds were able to successfully induce inflammatory gene expression (interleukin‐1β) in the head kidneys of infected fish at 13 and 26 days post‐exposure ( DPE ), and 13 DPE , respectively. Lice burdens were lower on fish fed CpG ODN (18%) or A quate ® (19%) diets; however, due to variability, these were not statistically significant over time. Despite no statistically significant reductions in lice numbers, by 33 DPE fish on immunostimulatory feeds had significantly reduced cortisol levels when compared to infected fish on control diet. Cortisol levels in fish receiving an immunostimulatory diet were no different from initial baseline levels prior to infection, whereas the levels in control diet fish were significantly elevated from all other time points. Despite the positive effects on infection of fish fed immunostimulatory feeds, no synergism was observed with follow‐up treatment with SLICE ® . In fact, ... Article in Journal/Newspaper Atlantic salmon Wiley Online Library (via Crossref) Almo ENVELOPE(15.306,15.306,66.954,66.954) Journal of Fish Diseases 36 3 299 309 |
institution |
Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Veterinary (miscellaneous) Aquatic Science |
spellingShingle |
Veterinary (miscellaneous) Aquatic Science Poley, J Purcell, S L Igboeli, O O Donkin, A Wotton, H Fast, M D Combinatorial effects of administration of immunostimulatory compounds in feed and follow‐up administration of triple‐dose <scp>SLICE</scp> ® (<scp>e</scp>mamectin benzoate) on <scp>A</scp>tlantic salmon, <scp>S</scp>almo salar L., infection with <scp>L</scp>epeophtheirus salmonis |
topic_facet |
Veterinary (miscellaneous) Aquatic Science |
description |
Abstract Several immunostimulatory feed additives have shown the ability to induce protective responses in A tlantic salmon to infection with L epeophtheirus salmonis . However, even the most encouraging results rarely surpass a 50% protective index in the host. That fact coupled with the well‐documented limitations of single‐therapy strategies in the effective management of parasitic infections generally make it imperative to identify therapies that can be combined in an integrated pest management approach for sea lice. With this in mind, we hypothesized that immunostimulatory feeds could enhance the protection provided by SLICE ® emamectin benzoate ( EMB ). To test this hypothesis, Atlantic salmon were fed one of two different immunostimulatory feeds ( CpG ODN or A quate ® ) for c . 7 weeks, challenged with L . salmonis copepodids early within that immunostimulatory feed period and then placed on a triple‐dose (150 μg kg −1 ) feed of SLICE ® for 1 week following the completion of the immunostimulatory feeding period. CpG ODN (2 mg kg −1 ) and the commercial yeast extract ( A quate ® 0.2%) inclusion in feeds were able to successfully induce inflammatory gene expression (interleukin‐1β) in the head kidneys of infected fish at 13 and 26 days post‐exposure ( DPE ), and 13 DPE , respectively. Lice burdens were lower on fish fed CpG ODN (18%) or A quate ® (19%) diets; however, due to variability, these were not statistically significant over time. Despite no statistically significant reductions in lice numbers, by 33 DPE fish on immunostimulatory feeds had significantly reduced cortisol levels when compared to infected fish on control diet. Cortisol levels in fish receiving an immunostimulatory diet were no different from initial baseline levels prior to infection, whereas the levels in control diet fish were significantly elevated from all other time points. Despite the positive effects on infection of fish fed immunostimulatory feeds, no synergism was observed with follow‐up treatment with SLICE ® . In fact, ... |
author2 |
NSERC engage programme Springboard Atlantic Northeast Nutrition and Cooke Aquaculture Ltd. Aquatic Animal Facilities and staff at AVC-UPEI |
format |
Article in Journal/Newspaper |
author |
Poley, J Purcell, S L Igboeli, O O Donkin, A Wotton, H Fast, M D |
author_facet |
Poley, J Purcell, S L Igboeli, O O Donkin, A Wotton, H Fast, M D |
author_sort |
Poley, J |
title |
Combinatorial effects of administration of immunostimulatory compounds in feed and follow‐up administration of triple‐dose <scp>SLICE</scp> ® (<scp>e</scp>mamectin benzoate) on <scp>A</scp>tlantic salmon, <scp>S</scp>almo salar L., infection with <scp>L</scp>epeophtheirus salmonis |
title_short |
Combinatorial effects of administration of immunostimulatory compounds in feed and follow‐up administration of triple‐dose <scp>SLICE</scp> ® (<scp>e</scp>mamectin benzoate) on <scp>A</scp>tlantic salmon, <scp>S</scp>almo salar L., infection with <scp>L</scp>epeophtheirus salmonis |
title_full |
Combinatorial effects of administration of immunostimulatory compounds in feed and follow‐up administration of triple‐dose <scp>SLICE</scp> ® (<scp>e</scp>mamectin benzoate) on <scp>A</scp>tlantic salmon, <scp>S</scp>almo salar L., infection with <scp>L</scp>epeophtheirus salmonis |
title_fullStr |
Combinatorial effects of administration of immunostimulatory compounds in feed and follow‐up administration of triple‐dose <scp>SLICE</scp> ® (<scp>e</scp>mamectin benzoate) on <scp>A</scp>tlantic salmon, <scp>S</scp>almo salar L., infection with <scp>L</scp>epeophtheirus salmonis |
title_full_unstemmed |
Combinatorial effects of administration of immunostimulatory compounds in feed and follow‐up administration of triple‐dose <scp>SLICE</scp> ® (<scp>e</scp>mamectin benzoate) on <scp>A</scp>tlantic salmon, <scp>S</scp>almo salar L., infection with <scp>L</scp>epeophtheirus salmonis |
title_sort |
combinatorial effects of administration of immunostimulatory compounds in feed and follow‐up administration of triple‐dose <scp>slice</scp> ® (<scp>e</scp>mamectin benzoate) on <scp>a</scp>tlantic salmon, <scp>s</scp>almo salar l., infection with <scp>l</scp>epeophtheirus salmonis |
publisher |
Wiley |
publishDate |
2013 |
url |
http://dx.doi.org/10.1111/jfd.12062 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjfd.12062 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.12062 |
long_lat |
ENVELOPE(15.306,15.306,66.954,66.954) |
geographic |
Almo |
geographic_facet |
Almo |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Journal of Fish Diseases volume 36, issue 3, page 299-309 ISSN 0140-7775 1365-2761 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/jfd.12062 |
container_title |
Journal of Fish Diseases |
container_volume |
36 |
container_issue |
3 |
container_start_page |
299 |
op_container_end_page |
309 |
_version_ |
1784267144710586368 |