The established and the challenger: A direct comparison of current cryoballoon technologies for pulmonary vein isolation
Abstract Introduction Cryoballoon (CB) ablation for pulmonary vein isolation (PVI) is an effective treatment of atrial fibrillation (AF). Recently, a novel cryoablation system was introduced. The aim of the study was to compare the safety, efficacy and biophysical characteristics of a novel cryoabla...
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crwiley:10.1111/jce.15288 2024-10-13T14:05:36+00:00 The established and the challenger: A direct comparison of current cryoballoon technologies for pulmonary vein isolation Moser, Fabian Rottner, Laura Moser, Julia Schleberger, Ruben Lemoine, Marc Münkler, Paula Dinshaw, Leon Kirchhof, Paulus Reissmann, Bruno Ouyang, Feifan Rillig, Andreas Metzner, Andreas 2021 http://dx.doi.org/10.1111/jce.15288 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jce.15288 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jce.15288 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ Journal of Cardiovascular Electrophysiology volume 33, issue 1, page 48-54 ISSN 1045-3873 1540-8167 journal-article 2021 crwiley https://doi.org/10.1111/jce.15288 2024-09-27T04:17:34Z Abstract Introduction Cryoballoon (CB) ablation for pulmonary vein isolation (PVI) is an effective treatment of atrial fibrillation (AF). Recently, a novel cryoablation system was introduced. The aim of the study was to compare the safety, efficacy and biophysical characteristics of a novel cryoablation system (POLARx™; Boston Scientific) to a commonly used and clinically well characterized system (Arctic Front Advance Pro™, AFA; Medtronic). Methods and Results Fifty consecutive patients with symptomatic AF, who underwent CB‐based ablation with the POLARx were compared to 50 consecutive patients treated with the AFA. Acute PVI was achieved in 99.8% (POLARx 99.5%, AFA 100%, p = 1.00). Time to isolation (TTI) was comparable in both groups (POLARx 35 [27, 48] s, AFA 30 [21, 43] s, p = 0.165). The POLARx showed a lower balloon temperature at TTI (POLARx −44 [−50, −36] °C, AFA −31 [−38, −21] °C, p < 0.001) and lower nadir temperature (POLARx −60 [−65, −55] °C, AFA −48 [−54, −45] °C, p < 0.001). Procedure time (POLARx 80 [60, 105] min, AFA 62 [42, 80] min, p < 0.001), fluoroscopy time (POLARx 17 [13, 22] min, AFA 11 [7, 16] min, p < 0.001) and freeze cycles per patient (POLARx 5 [4, 6], AFA 4.5 [4, 5], p = 0.002) were higher in the POLARx group. Two cerebral ischemic events occurred in the POLARx group, two patients in each group had phrenic nerve injury. Conclusion Both systems enable effective isolation of pulmonary veins. The POLARx required longer procedure and fluoroscopy times. Larger, prospective and randomized studies are needed to assess long‐term efficacy and safety of this technology. Article in Journal/Newspaper Arctic Wiley Online Library Arctic Journal of Cardiovascular Electrophysiology 33 1 48 54 |
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Abstract Introduction Cryoballoon (CB) ablation for pulmonary vein isolation (PVI) is an effective treatment of atrial fibrillation (AF). Recently, a novel cryoablation system was introduced. The aim of the study was to compare the safety, efficacy and biophysical characteristics of a novel cryoablation system (POLARx™; Boston Scientific) to a commonly used and clinically well characterized system (Arctic Front Advance Pro™, AFA; Medtronic). Methods and Results Fifty consecutive patients with symptomatic AF, who underwent CB‐based ablation with the POLARx were compared to 50 consecutive patients treated with the AFA. Acute PVI was achieved in 99.8% (POLARx 99.5%, AFA 100%, p = 1.00). Time to isolation (TTI) was comparable in both groups (POLARx 35 [27, 48] s, AFA 30 [21, 43] s, p = 0.165). The POLARx showed a lower balloon temperature at TTI (POLARx −44 [−50, −36] °C, AFA −31 [−38, −21] °C, p < 0.001) and lower nadir temperature (POLARx −60 [−65, −55] °C, AFA −48 [−54, −45] °C, p < 0.001). Procedure time (POLARx 80 [60, 105] min, AFA 62 [42, 80] min, p < 0.001), fluoroscopy time (POLARx 17 [13, 22] min, AFA 11 [7, 16] min, p < 0.001) and freeze cycles per patient (POLARx 5 [4, 6], AFA 4.5 [4, 5], p = 0.002) were higher in the POLARx group. Two cerebral ischemic events occurred in the POLARx group, two patients in each group had phrenic nerve injury. Conclusion Both systems enable effective isolation of pulmonary veins. The POLARx required longer procedure and fluoroscopy times. Larger, prospective and randomized studies are needed to assess long‐term efficacy and safety of this technology. |
format |
Article in Journal/Newspaper |
author |
Moser, Fabian Rottner, Laura Moser, Julia Schleberger, Ruben Lemoine, Marc Münkler, Paula Dinshaw, Leon Kirchhof, Paulus Reissmann, Bruno Ouyang, Feifan Rillig, Andreas Metzner, Andreas |
spellingShingle |
Moser, Fabian Rottner, Laura Moser, Julia Schleberger, Ruben Lemoine, Marc Münkler, Paula Dinshaw, Leon Kirchhof, Paulus Reissmann, Bruno Ouyang, Feifan Rillig, Andreas Metzner, Andreas The established and the challenger: A direct comparison of current cryoballoon technologies for pulmonary vein isolation |
author_facet |
Moser, Fabian Rottner, Laura Moser, Julia Schleberger, Ruben Lemoine, Marc Münkler, Paula Dinshaw, Leon Kirchhof, Paulus Reissmann, Bruno Ouyang, Feifan Rillig, Andreas Metzner, Andreas |
author_sort |
Moser, Fabian |
title |
The established and the challenger: A direct comparison of current cryoballoon technologies for pulmonary vein isolation |
title_short |
The established and the challenger: A direct comparison of current cryoballoon technologies for pulmonary vein isolation |
title_full |
The established and the challenger: A direct comparison of current cryoballoon technologies for pulmonary vein isolation |
title_fullStr |
The established and the challenger: A direct comparison of current cryoballoon technologies for pulmonary vein isolation |
title_full_unstemmed |
The established and the challenger: A direct comparison of current cryoballoon technologies for pulmonary vein isolation |
title_sort |
established and the challenger: a direct comparison of current cryoballoon technologies for pulmonary vein isolation |
publisher |
Wiley |
publishDate |
2021 |
url |
http://dx.doi.org/10.1111/jce.15288 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jce.15288 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jce.15288 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Cardiovascular Electrophysiology volume 33, issue 1, page 48-54 ISSN 1045-3873 1540-8167 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1111/jce.15288 |
container_title |
Journal of Cardiovascular Electrophysiology |
container_volume |
33 |
container_issue |
1 |
container_start_page |
48 |
op_container_end_page |
54 |
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1812811678595678208 |