Clinical Findings in 40 Dogs with Hypersensitivity Associated with Administration of Potentiated Sulfonamides
The purpose of this study was to summarize the clinical findings in 40 dogs with systemic hypersensitivity reactions associated with the administration of potentiated sulfonamides. Dogs ranged from 6 months to 14 years of age, with a mean of 5.7 ± 3.2 years. Spayed female dogs were overrepresented (...
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crwiley:10.1111/j.1939-1676.2003.tb02495.x 2024-04-21T08:11:02+00:00 Clinical Findings in 40 Dogs with Hypersensitivity Associated with Administration of Potentiated Sulfonamides Trepanier, Lauren A. Danhof, Rebecca Toll, Jeffrey Watrous, Deborah 2003 http://dx.doi.org/10.1111/j.1939-1676.2003.tb02495.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1939-1676.2003.tb02495.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1939-1676.2003.tb02495.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Veterinary Internal Medicine volume 17, issue 5, page 647-652 ISSN 0891-6640 1939-1676 General Veterinary journal-article 2003 crwiley https://doi.org/10.1111/j.1939-1676.2003.tb02495.x 2024-03-28T08:28:08Z The purpose of this study was to summarize the clinical findings in 40 dogs with systemic hypersensitivity reactions associated with the administration of potentiated sulfonamides. Dogs ranged from 6 months to 14 years of age, with a mean of 5.7 ± 3.2 years. Spayed female dogs were overrepresented (24 of 40, or 60% of the dogs), as were Samoyeds (3 of 40; 8%) and Miniature Schnauzers (5 of 40; 13%). Mean dosages of potentiated sulfonamides were 47.0 ± 14.9 mg/kg/d (range, 23.4–81.4 mg/kg/d). The time from the 1st administration of the drug to the onset of the clinical signs of hypersensitivity ranged from 5 to 36 days, with a mean of 12.1 ± 5.9 days. There was no relationship between either the dosage or type of sulfonamide given and the time to the onset of the clinical signs. Fever was the most common clinical sign observed (55% of the dogs); thrombocytopenia was 2nd (54%), and hepatopathy (28%) was 3rd. Neutropenia, keratoconjunctivitis sicca (KCS), hemolytic anemia, arthropathy, uveitis, skin and mucocutaneous lesions, proteinuria, facial palsy, suspected meningitis, hypothyroidism, pancreatitis, facial edema, and pneumonitis were also observed in some patients. Of 39 dogs with adequate follow‐up, 30 (77%) recovered, whereas 8 (21%) either died or were euthanized, and 1 recovered clinically but had persistent increases in alanine aminotransferase (ALT) activity. Dogs with hepatopathy generally had a poorer prognosis (46% recovery) than dogs without hepatopathy (89% recovery; P = .0035). Sixty‐three percent of the dogs with thrombocytopenia recovered, compared to 90% of the dogs without thrombocytopenia (P = .042). Recovery was not associated with sex, age, breed, or type of sulfonamide administered. Article in Journal/Newspaper samoyed* Wiley Online Library Journal of Veterinary Internal Medicine 17 5 647 652 |
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language |
English |
topic |
General Veterinary |
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General Veterinary Trepanier, Lauren A. Danhof, Rebecca Toll, Jeffrey Watrous, Deborah Clinical Findings in 40 Dogs with Hypersensitivity Associated with Administration of Potentiated Sulfonamides |
topic_facet |
General Veterinary |
description |
The purpose of this study was to summarize the clinical findings in 40 dogs with systemic hypersensitivity reactions associated with the administration of potentiated sulfonamides. Dogs ranged from 6 months to 14 years of age, with a mean of 5.7 ± 3.2 years. Spayed female dogs were overrepresented (24 of 40, or 60% of the dogs), as were Samoyeds (3 of 40; 8%) and Miniature Schnauzers (5 of 40; 13%). Mean dosages of potentiated sulfonamides were 47.0 ± 14.9 mg/kg/d (range, 23.4–81.4 mg/kg/d). The time from the 1st administration of the drug to the onset of the clinical signs of hypersensitivity ranged from 5 to 36 days, with a mean of 12.1 ± 5.9 days. There was no relationship between either the dosage or type of sulfonamide given and the time to the onset of the clinical signs. Fever was the most common clinical sign observed (55% of the dogs); thrombocytopenia was 2nd (54%), and hepatopathy (28%) was 3rd. Neutropenia, keratoconjunctivitis sicca (KCS), hemolytic anemia, arthropathy, uveitis, skin and mucocutaneous lesions, proteinuria, facial palsy, suspected meningitis, hypothyroidism, pancreatitis, facial edema, and pneumonitis were also observed in some patients. Of 39 dogs with adequate follow‐up, 30 (77%) recovered, whereas 8 (21%) either died or were euthanized, and 1 recovered clinically but had persistent increases in alanine aminotransferase (ALT) activity. Dogs with hepatopathy generally had a poorer prognosis (46% recovery) than dogs without hepatopathy (89% recovery; P = .0035). Sixty‐three percent of the dogs with thrombocytopenia recovered, compared to 90% of the dogs without thrombocytopenia (P = .042). Recovery was not associated with sex, age, breed, or type of sulfonamide administered. |
format |
Article in Journal/Newspaper |
author |
Trepanier, Lauren A. Danhof, Rebecca Toll, Jeffrey Watrous, Deborah |
author_facet |
Trepanier, Lauren A. Danhof, Rebecca Toll, Jeffrey Watrous, Deborah |
author_sort |
Trepanier, Lauren A. |
title |
Clinical Findings in 40 Dogs with Hypersensitivity Associated with Administration of Potentiated Sulfonamides |
title_short |
Clinical Findings in 40 Dogs with Hypersensitivity Associated with Administration of Potentiated Sulfonamides |
title_full |
Clinical Findings in 40 Dogs with Hypersensitivity Associated with Administration of Potentiated Sulfonamides |
title_fullStr |
Clinical Findings in 40 Dogs with Hypersensitivity Associated with Administration of Potentiated Sulfonamides |
title_full_unstemmed |
Clinical Findings in 40 Dogs with Hypersensitivity Associated with Administration of Potentiated Sulfonamides |
title_sort |
clinical findings in 40 dogs with hypersensitivity associated with administration of potentiated sulfonamides |
publisher |
Wiley |
publishDate |
2003 |
url |
http://dx.doi.org/10.1111/j.1939-1676.2003.tb02495.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1939-1676.2003.tb02495.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1939-1676.2003.tb02495.x |
genre |
samoyed* |
genre_facet |
samoyed* |
op_source |
Journal of Veterinary Internal Medicine volume 17, issue 5, page 647-652 ISSN 0891-6640 1939-1676 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1939-1676.2003.tb02495.x |
container_title |
Journal of Veterinary Internal Medicine |
container_volume |
17 |
container_issue |
5 |
container_start_page |
647 |
op_container_end_page |
652 |
_version_ |
1796952661209120768 |