The Natural Clinical History of Canine Congenital Subaortic Stenosis
The demographics and natural clinical history of canine congenital subaortic stenosis (SAS) were evaluated by retrospective analysis of 195 confirmed cases (1967 to 1991), 96 of which were untreated and available for follow‐up evaluation. Of these, 58 dogs had left ventricular outflow systolic press...
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crwiley:10.1111/j.1939-1676.1994.tb03262.x 2024-06-23T07:54:49+00:00 The Natural Clinical History of Canine Congenital Subaortic Stenosis Kienle, Richard D. Thomas, William P. Pion, Paul D. 1994 http://dx.doi.org/10.1111/j.1939-1676.1994.tb03262.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1939-1676.1994.tb03262.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1939-1676.1994.tb03262.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Veterinary Internal Medicine volume 8, issue 6, page 423-431 ISSN 0891-6640 1939-1676 journal-article 1994 crwiley https://doi.org/10.1111/j.1939-1676.1994.tb03262.x 2024-05-31T08:13:36Z The demographics and natural clinical history of canine congenital subaortic stenosis (SAS) were evaluated by retrospective analysis of 195 confirmed cases (1967 to 1991), 96 of which were untreated and available for follow‐up evaluation. Of these, 58 dogs had left ventricular outflow systolic pressure gradients available for assessment of severity. All 195 dogs were used for demographic analysis. Breeds found to be at increased relative risk included the Newfoundland (odds ratio, 88.1; P < .001), Rottweiler (odds ratio, 19.3; P < .001), Boxer (odds ratio, 8.6; P < .001), and Golden Retriever (odds ratio, 5.5; P < .001). Dogs with mild gradients (16 to 35 mm Hg) and those that developed infective endocarditis or left heart failure were diagnosed at older ages than those with moderate (36 to 80 mm Hg) and severe (>80 mm Hg) gradients. Of 96 untreated dogs, 32 (33.3%) had signs of illness varying from fatigue to syncope; 11 dogs (11.3%) developed infective endocarditis or left heart failure. Exercise intolerance or fatigue was reported in 22 dogs, syncope in 11 dogs, and respiratory signs (cough, dyspnea, tachypnea) in 9 dogs. In addition, 21 dogs (21.9%) died suddenly. Sudden death occurred mainly in the first 3 years of life, primarily but not exclusively, in dogs with severe obstructions (gradient, > 80 mm Hg; odds ratio, 16.0; P < .001). Infective endocarditis (6.3%) and left heart failure (7.3%) tended to occur later in life and in dogs with mild to moderate obstructions. Left heart failure was uncommon in the absence of additional congenital defects or infective endocarditis. Dogs with mild obstructions lived longer than other groups and tended to remain asymptomatic. The majority of dogs with severe obstructions died before 3 years of age and had a high prevalence (8 of 15) of sudden death. The prognosis for long‐term survival in dogs with untreated mild or moderate SAS is favorable (median survival, 30.5 and 51.1 months, respectively), while the prognosis for dogs with severe SAS is ... Article in Journal/Newspaper Newfoundland Wiley Online Library Journal of Veterinary Internal Medicine 8 6 423 431 |
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Wiley Online Library |
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English |
description |
The demographics and natural clinical history of canine congenital subaortic stenosis (SAS) were evaluated by retrospective analysis of 195 confirmed cases (1967 to 1991), 96 of which were untreated and available for follow‐up evaluation. Of these, 58 dogs had left ventricular outflow systolic pressure gradients available for assessment of severity. All 195 dogs were used for demographic analysis. Breeds found to be at increased relative risk included the Newfoundland (odds ratio, 88.1; P < .001), Rottweiler (odds ratio, 19.3; P < .001), Boxer (odds ratio, 8.6; P < .001), and Golden Retriever (odds ratio, 5.5; P < .001). Dogs with mild gradients (16 to 35 mm Hg) and those that developed infective endocarditis or left heart failure were diagnosed at older ages than those with moderate (36 to 80 mm Hg) and severe (>80 mm Hg) gradients. Of 96 untreated dogs, 32 (33.3%) had signs of illness varying from fatigue to syncope; 11 dogs (11.3%) developed infective endocarditis or left heart failure. Exercise intolerance or fatigue was reported in 22 dogs, syncope in 11 dogs, and respiratory signs (cough, dyspnea, tachypnea) in 9 dogs. In addition, 21 dogs (21.9%) died suddenly. Sudden death occurred mainly in the first 3 years of life, primarily but not exclusively, in dogs with severe obstructions (gradient, > 80 mm Hg; odds ratio, 16.0; P < .001). Infective endocarditis (6.3%) and left heart failure (7.3%) tended to occur later in life and in dogs with mild to moderate obstructions. Left heart failure was uncommon in the absence of additional congenital defects or infective endocarditis. Dogs with mild obstructions lived longer than other groups and tended to remain asymptomatic. The majority of dogs with severe obstructions died before 3 years of age and had a high prevalence (8 of 15) of sudden death. The prognosis for long‐term survival in dogs with untreated mild or moderate SAS is favorable (median survival, 30.5 and 51.1 months, respectively), while the prognosis for dogs with severe SAS is ... |
format |
Article in Journal/Newspaper |
author |
Kienle, Richard D. Thomas, William P. Pion, Paul D. |
spellingShingle |
Kienle, Richard D. Thomas, William P. Pion, Paul D. The Natural Clinical History of Canine Congenital Subaortic Stenosis |
author_facet |
Kienle, Richard D. Thomas, William P. Pion, Paul D. |
author_sort |
Kienle, Richard D. |
title |
The Natural Clinical History of Canine Congenital Subaortic Stenosis |
title_short |
The Natural Clinical History of Canine Congenital Subaortic Stenosis |
title_full |
The Natural Clinical History of Canine Congenital Subaortic Stenosis |
title_fullStr |
The Natural Clinical History of Canine Congenital Subaortic Stenosis |
title_full_unstemmed |
The Natural Clinical History of Canine Congenital Subaortic Stenosis |
title_sort |
natural clinical history of canine congenital subaortic stenosis |
publisher |
Wiley |
publishDate |
1994 |
url |
http://dx.doi.org/10.1111/j.1939-1676.1994.tb03262.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1939-1676.1994.tb03262.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1939-1676.1994.tb03262.x |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Journal of Veterinary Internal Medicine volume 8, issue 6, page 423-431 ISSN 0891-6640 1939-1676 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1939-1676.1994.tb03262.x |
container_title |
Journal of Veterinary Internal Medicine |
container_volume |
8 |
container_issue |
6 |
container_start_page |
423 |
op_container_end_page |
431 |
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1802647083608440832 |