Varying disease‐mediated selection at different life‐history stages of Atlantic salmon in fresh water
Abstract Laboratory studies on associations between disease resistance and susceptibility and major histocompatibility (MH) genes in Atlantic salmon Salmo salar have shown the importance of immunogenetics in understanding the capacity of populations to fight specific diseases. However, the occurrenc...
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crwiley:10.1111/j.1752-4571.2011.00197.x 2023-12-03T10:19:31+01:00 Varying disease‐mediated selection at different life‐history stages of Atlantic salmon in fresh water de Eyto, Elvira McGinnity, Philip Huisman, Jisca Coughlan, Jamie Consuegra, Sofia Farrell, Killian O’Toole, Ciar Tufto, Jarle Megens, Hendrik‐Jan Jordan, William Cross, Tom Stet, Rene′ J. M. 2011 http://dx.doi.org/10.1111/j.1752-4571.2011.00197.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1752-4571.2011.00197.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1752-4571.2011.00197.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Evolutionary Applications volume 4, issue 6, page 749-762 ISSN 1752-4571 1752-4571 General Agricultural and Biological Sciences Genetics Ecology, Evolution, Behavior and Systematics journal-article 2011 crwiley https://doi.org/10.1111/j.1752-4571.2011.00197.x 2023-11-09T14:24:52Z Abstract Laboratory studies on associations between disease resistance and susceptibility and major histocompatibility (MH) genes in Atlantic salmon Salmo salar have shown the importance of immunogenetics in understanding the capacity of populations to fight specific diseases. However, the occurrence and virulence of pathogens may vary spatially and temporally in the wild, making it more complicated to predict the overall effect that MH genes exert on fitness of natural populations and over several life‐history stages. Here we show that MH variability is a significant determinant of salmon survival in fresh water, by comparing observed and expected genotype frequencies at MH and control microsatellite loci at parr and migrant stages in the wild. We found that additive allelic effects at immunogenetic loci were more likely to determine survival than dominance deviation, and that selection on certain MH alleles varied with life stage, possibly owing to varying pathogen prevalence and/or virulence over time. Our results highlight the importance of preserving genetic diversity (particularly at MH loci) in wild populations, so that they have the best chance of adapting to new and increased disease challenges as a result of projected climate warming and increasing aquaculture. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library (via Crossref) Evolutionary Applications 4 6 749 762 |
institution |
Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
General Agricultural and Biological Sciences Genetics Ecology, Evolution, Behavior and Systematics |
spellingShingle |
General Agricultural and Biological Sciences Genetics Ecology, Evolution, Behavior and Systematics de Eyto, Elvira McGinnity, Philip Huisman, Jisca Coughlan, Jamie Consuegra, Sofia Farrell, Killian O’Toole, Ciar Tufto, Jarle Megens, Hendrik‐Jan Jordan, William Cross, Tom Stet, Rene′ J. M. Varying disease‐mediated selection at different life‐history stages of Atlantic salmon in fresh water |
topic_facet |
General Agricultural and Biological Sciences Genetics Ecology, Evolution, Behavior and Systematics |
description |
Abstract Laboratory studies on associations between disease resistance and susceptibility and major histocompatibility (MH) genes in Atlantic salmon Salmo salar have shown the importance of immunogenetics in understanding the capacity of populations to fight specific diseases. However, the occurrence and virulence of pathogens may vary spatially and temporally in the wild, making it more complicated to predict the overall effect that MH genes exert on fitness of natural populations and over several life‐history stages. Here we show that MH variability is a significant determinant of salmon survival in fresh water, by comparing observed and expected genotype frequencies at MH and control microsatellite loci at parr and migrant stages in the wild. We found that additive allelic effects at immunogenetic loci were more likely to determine survival than dominance deviation, and that selection on certain MH alleles varied with life stage, possibly owing to varying pathogen prevalence and/or virulence over time. Our results highlight the importance of preserving genetic diversity (particularly at MH loci) in wild populations, so that they have the best chance of adapting to new and increased disease challenges as a result of projected climate warming and increasing aquaculture. |
format |
Article in Journal/Newspaper |
author |
de Eyto, Elvira McGinnity, Philip Huisman, Jisca Coughlan, Jamie Consuegra, Sofia Farrell, Killian O’Toole, Ciar Tufto, Jarle Megens, Hendrik‐Jan Jordan, William Cross, Tom Stet, Rene′ J. M. |
author_facet |
de Eyto, Elvira McGinnity, Philip Huisman, Jisca Coughlan, Jamie Consuegra, Sofia Farrell, Killian O’Toole, Ciar Tufto, Jarle Megens, Hendrik‐Jan Jordan, William Cross, Tom Stet, Rene′ J. M. |
author_sort |
de Eyto, Elvira |
title |
Varying disease‐mediated selection at different life‐history stages of Atlantic salmon in fresh water |
title_short |
Varying disease‐mediated selection at different life‐history stages of Atlantic salmon in fresh water |
title_full |
Varying disease‐mediated selection at different life‐history stages of Atlantic salmon in fresh water |
title_fullStr |
Varying disease‐mediated selection at different life‐history stages of Atlantic salmon in fresh water |
title_full_unstemmed |
Varying disease‐mediated selection at different life‐history stages of Atlantic salmon in fresh water |
title_sort |
varying disease‐mediated selection at different life‐history stages of atlantic salmon in fresh water |
publisher |
Wiley |
publishDate |
2011 |
url |
http://dx.doi.org/10.1111/j.1752-4571.2011.00197.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1752-4571.2011.00197.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1752-4571.2011.00197.x |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Evolutionary Applications volume 4, issue 6, page 749-762 ISSN 1752-4571 1752-4571 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1752-4571.2011.00197.x |
container_title |
Evolutionary Applications |
container_volume |
4 |
container_issue |
6 |
container_start_page |
749 |
op_container_end_page |
762 |
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1784266821552046080 |