Addictions and their familiality in Iceland
Here, we provide an overview of previous family studies of addiction and present a new family study based on clinical data for more than 19,000 individuals who have been treated for addiction in Iceland over the last three decades. Coupled with the extensive Icelandic genealogy information, this pop...
Published in: | Annals of the New York Academy of Sciences |
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Online Access: | http://dx.doi.org/10.1111/j.1749-6632.2009.05151.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1749-6632.2009.05151.x https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2009.05151.x |
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crwiley:10.1111/j.1749-6632.2009.05151.x 2024-09-15T18:13:19+00:00 Addictions and their familiality in Iceland Tyrfingsson, Thorarinn Thorgeirsson, Thorgeir E. Geller, Frank Runarsdóttir, Valgerdur Hansdóttir, Ingunn Bjornsdottir, Gyda Wiste, Anna K. Jonsdottir, Gudrun A. Stefansson, Hreinn Gulcher, Jeffrey R. Oskarsson, Hogni Gudbjartsson, Daniel Stefansson, Kari 2010 http://dx.doi.org/10.1111/j.1749-6632.2009.05151.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1749-6632.2009.05151.x https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2009.05151.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Annals of the New York Academy of Sciences volume 1187, issue 1, page 208-217 ISSN 0077-8923 1749-6632 journal-article 2010 crwiley https://doi.org/10.1111/j.1749-6632.2009.05151.x 2024-08-01T04:23:38Z Here, we provide an overview of previous family studies of addiction and present a new family study based on clinical data for more than 19,000 individuals who have been treated for addiction in Iceland over the last three decades. Coupled with the extensive Icelandic genealogy information, this population‐based sample provides a unique opportunity for family studies. The relative risk (RR) was determined for up to fifth‐degree relatives of probands diagnosed with alcohol, cannabis, sedative, and amphetamine dependence. We observe highly significant RR values for all substances ranging from 2.27 for alcohol to 7.3 for amphetamine, for first‐degree relatives, and RRs significantly above 1 for distant relations, where the effect of shared environmental factors is minimized. The magnitude of risk in psychostimulant dependence is particularly striking. These findings emphasize the role of genetics in the etiology of addiction and highlight the importance of substance‐specific effects. Article in Journal/Newspaper Iceland Wiley Online Library Annals of the New York Academy of Sciences 1187 1 208 217 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Here, we provide an overview of previous family studies of addiction and present a new family study based on clinical data for more than 19,000 individuals who have been treated for addiction in Iceland over the last three decades. Coupled with the extensive Icelandic genealogy information, this population‐based sample provides a unique opportunity for family studies. The relative risk (RR) was determined for up to fifth‐degree relatives of probands diagnosed with alcohol, cannabis, sedative, and amphetamine dependence. We observe highly significant RR values for all substances ranging from 2.27 for alcohol to 7.3 for amphetamine, for first‐degree relatives, and RRs significantly above 1 for distant relations, where the effect of shared environmental factors is minimized. The magnitude of risk in psychostimulant dependence is particularly striking. These findings emphasize the role of genetics in the etiology of addiction and highlight the importance of substance‐specific effects. |
format |
Article in Journal/Newspaper |
author |
Tyrfingsson, Thorarinn Thorgeirsson, Thorgeir E. Geller, Frank Runarsdóttir, Valgerdur Hansdóttir, Ingunn Bjornsdottir, Gyda Wiste, Anna K. Jonsdottir, Gudrun A. Stefansson, Hreinn Gulcher, Jeffrey R. Oskarsson, Hogni Gudbjartsson, Daniel Stefansson, Kari |
spellingShingle |
Tyrfingsson, Thorarinn Thorgeirsson, Thorgeir E. Geller, Frank Runarsdóttir, Valgerdur Hansdóttir, Ingunn Bjornsdottir, Gyda Wiste, Anna K. Jonsdottir, Gudrun A. Stefansson, Hreinn Gulcher, Jeffrey R. Oskarsson, Hogni Gudbjartsson, Daniel Stefansson, Kari Addictions and their familiality in Iceland |
author_facet |
Tyrfingsson, Thorarinn Thorgeirsson, Thorgeir E. Geller, Frank Runarsdóttir, Valgerdur Hansdóttir, Ingunn Bjornsdottir, Gyda Wiste, Anna K. Jonsdottir, Gudrun A. Stefansson, Hreinn Gulcher, Jeffrey R. Oskarsson, Hogni Gudbjartsson, Daniel Stefansson, Kari |
author_sort |
Tyrfingsson, Thorarinn |
title |
Addictions and their familiality in Iceland |
title_short |
Addictions and their familiality in Iceland |
title_full |
Addictions and their familiality in Iceland |
title_fullStr |
Addictions and their familiality in Iceland |
title_full_unstemmed |
Addictions and their familiality in Iceland |
title_sort |
addictions and their familiality in iceland |
publisher |
Wiley |
publishDate |
2010 |
url |
http://dx.doi.org/10.1111/j.1749-6632.2009.05151.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1749-6632.2009.05151.x https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2009.05151.x |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Annals of the New York Academy of Sciences volume 1187, issue 1, page 208-217 ISSN 0077-8923 1749-6632 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1749-6632.2009.05151.x |
container_title |
Annals of the New York Academy of Sciences |
container_volume |
1187 |
container_issue |
1 |
container_start_page |
208 |
op_container_end_page |
217 |
_version_ |
1810451072707198976 |