ADRENAL FUNCTION IN WILD AND REHABILITATED PACIFIC HARBOR SEALS ( PHOCA VITULINA RICHARDII ) AND IN SEALS WITH PHOCINE HERPESVIRUS‐ASSOCIATED ADRENAL NECROSIS
A bstract Adrenal function in harbor seals ( Phoca vitulina richardii ) was evaluated using adrenocorticotrophic hormone (ACTH) stimulation tests and fecal cortisol levels. The effect of ACTH administration on plasma cortisol and aldosterone levels in five free‐living and 14 rehabilitated harbor sea...
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Wiley
1999
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Online Access: | http://dx.doi.org/10.1111/j.1748-7692.1999.tb00844.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-7692.1999.tb00844.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-7692.1999.tb00844.x |
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crwiley:10.1111/j.1748-7692.1999.tb00844.x 2023-12-03T10:23:45+01:00 ADRENAL FUNCTION IN WILD AND REHABILITATED PACIFIC HARBOR SEALS ( PHOCA VITULINA RICHARDII ) AND IN SEALS WITH PHOCINE HERPESVIRUS‐ASSOCIATED ADRENAL NECROSIS Gulland, F. M. D. Haulena, M. Lowenstine, L. J. Munro, C. Graham, P. A. Bauman, J. Harvey, J. 1999 http://dx.doi.org/10.1111/j.1748-7692.1999.tb00844.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-7692.1999.tb00844.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-7692.1999.tb00844.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Marine Mammal Science volume 15, issue 3, page 810-827 ISSN 0824-0469 1748-7692 Aquatic Science Ecology, Evolution, Behavior and Systematics journal-article 1999 crwiley https://doi.org/10.1111/j.1748-7692.1999.tb00844.x 2023-11-09T14:16:41Z A bstract Adrenal function in harbor seals ( Phoca vitulina richardii ) was evaluated using adrenocorticotrophic hormone (ACTH) stimulation tests and fecal cortisol levels. The effect of ACTH administration on plasma cortisol and aldosterone levels in five free‐living and 14 rehabilitated harbor seal pups was determined using enzyme immunoassay and radioimmunoassay, respectively. In free‐living seals, injection of ACTH caused a significant increase in mean plasma cortisol but not of mean aldosterone levels 60 min postinjection. In these seals, mean initial plasma aldosterone was significantly higher than initial levels in rehabilitated seals, while initial cortisol levels were similar. Of the rehabilitated seals, eight died with adrenal cortical necrosis associated with herpesvirus inclusions, while six lived to be released. In the seals that were released, both mean initial cortisol levels and response to ACTH decreased through rehabilitation. In the seals that died, mean initial cortisol and response to ACTH increased through rehabilitation. The differences between initial cortisol levels in seals that lived and those that died were significant at weeks two and four of rehabilitation but not at the week of admission. There was considerable individual variation in initial plasma aldosterone levels and responses to ACTH, although initial aldosterone levels were significantly higher in rehabilitated seals that died than in seals that lived. Seals with adrenal necrosis associated with herpesvirus infection did not have decreased adrenal hormone responses to ACTH. Differences between initial hormone levels and responses to ACTH in different groups of seals may be associated with differing stress levels. Fecal cortisol assays were not a useful method of assessing adrenal function in these seals, as measured levels did not correlate with plasma cortisol levels. Article in Journal/Newspaper harbor seal Phoca vitulina Wiley Online Library (via Crossref) Pacific Marine Mammal Science 15 3 810 827 |
institution |
Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Aquatic Science Ecology, Evolution, Behavior and Systematics |
spellingShingle |
Aquatic Science Ecology, Evolution, Behavior and Systematics Gulland, F. M. D. Haulena, M. Lowenstine, L. J. Munro, C. Graham, P. A. Bauman, J. Harvey, J. ADRENAL FUNCTION IN WILD AND REHABILITATED PACIFIC HARBOR SEALS ( PHOCA VITULINA RICHARDII ) AND IN SEALS WITH PHOCINE HERPESVIRUS‐ASSOCIATED ADRENAL NECROSIS |
topic_facet |
Aquatic Science Ecology, Evolution, Behavior and Systematics |
description |
A bstract Adrenal function in harbor seals ( Phoca vitulina richardii ) was evaluated using adrenocorticotrophic hormone (ACTH) stimulation tests and fecal cortisol levels. The effect of ACTH administration on plasma cortisol and aldosterone levels in five free‐living and 14 rehabilitated harbor seal pups was determined using enzyme immunoassay and radioimmunoassay, respectively. In free‐living seals, injection of ACTH caused a significant increase in mean plasma cortisol but not of mean aldosterone levels 60 min postinjection. In these seals, mean initial plasma aldosterone was significantly higher than initial levels in rehabilitated seals, while initial cortisol levels were similar. Of the rehabilitated seals, eight died with adrenal cortical necrosis associated with herpesvirus inclusions, while six lived to be released. In the seals that were released, both mean initial cortisol levels and response to ACTH decreased through rehabilitation. In the seals that died, mean initial cortisol and response to ACTH increased through rehabilitation. The differences between initial cortisol levels in seals that lived and those that died were significant at weeks two and four of rehabilitation but not at the week of admission. There was considerable individual variation in initial plasma aldosterone levels and responses to ACTH, although initial aldosterone levels were significantly higher in rehabilitated seals that died than in seals that lived. Seals with adrenal necrosis associated with herpesvirus infection did not have decreased adrenal hormone responses to ACTH. Differences between initial hormone levels and responses to ACTH in different groups of seals may be associated with differing stress levels. Fecal cortisol assays were not a useful method of assessing adrenal function in these seals, as measured levels did not correlate with plasma cortisol levels. |
format |
Article in Journal/Newspaper |
author |
Gulland, F. M. D. Haulena, M. Lowenstine, L. J. Munro, C. Graham, P. A. Bauman, J. Harvey, J. |
author_facet |
Gulland, F. M. D. Haulena, M. Lowenstine, L. J. Munro, C. Graham, P. A. Bauman, J. Harvey, J. |
author_sort |
Gulland, F. M. D. |
title |
ADRENAL FUNCTION IN WILD AND REHABILITATED PACIFIC HARBOR SEALS ( PHOCA VITULINA RICHARDII ) AND IN SEALS WITH PHOCINE HERPESVIRUS‐ASSOCIATED ADRENAL NECROSIS |
title_short |
ADRENAL FUNCTION IN WILD AND REHABILITATED PACIFIC HARBOR SEALS ( PHOCA VITULINA RICHARDII ) AND IN SEALS WITH PHOCINE HERPESVIRUS‐ASSOCIATED ADRENAL NECROSIS |
title_full |
ADRENAL FUNCTION IN WILD AND REHABILITATED PACIFIC HARBOR SEALS ( PHOCA VITULINA RICHARDII ) AND IN SEALS WITH PHOCINE HERPESVIRUS‐ASSOCIATED ADRENAL NECROSIS |
title_fullStr |
ADRENAL FUNCTION IN WILD AND REHABILITATED PACIFIC HARBOR SEALS ( PHOCA VITULINA RICHARDII ) AND IN SEALS WITH PHOCINE HERPESVIRUS‐ASSOCIATED ADRENAL NECROSIS |
title_full_unstemmed |
ADRENAL FUNCTION IN WILD AND REHABILITATED PACIFIC HARBOR SEALS ( PHOCA VITULINA RICHARDII ) AND IN SEALS WITH PHOCINE HERPESVIRUS‐ASSOCIATED ADRENAL NECROSIS |
title_sort |
adrenal function in wild and rehabilitated pacific harbor seals ( phoca vitulina richardii ) and in seals with phocine herpesvirus‐associated adrenal necrosis |
publisher |
Wiley |
publishDate |
1999 |
url |
http://dx.doi.org/10.1111/j.1748-7692.1999.tb00844.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-7692.1999.tb00844.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-7692.1999.tb00844.x |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
harbor seal Phoca vitulina |
genre_facet |
harbor seal Phoca vitulina |
op_source |
Marine Mammal Science volume 15, issue 3, page 810-827 ISSN 0824-0469 1748-7692 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1748-7692.1999.tb00844.x |
container_title |
Marine Mammal Science |
container_volume |
15 |
container_issue |
3 |
container_start_page |
810 |
op_container_end_page |
827 |
_version_ |
1784272008949792768 |