Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis
Abstract A group of non‐azotaemic bull terriers from families with hereditary nephritis had significant subclinical renal disease. Of the renal function tests carried out, proteinuria, almost exclusively albumin, was a reliable and early indicator of glomerular abnormality. While 24‐hour urinary pro...
Published in: | Journal of Small Animal Practice |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
1991
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1111/j.1748-5827.1991.tb00556.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-5827.1991.tb00556.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-5827.1991.tb00556.x |
id |
crwiley:10.1111/j.1748-5827.1991.tb00556.x |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1111/j.1748-5827.1991.tb00556.x 2023-12-03T10:29:57+01:00 Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis Hood, J. C. Robinson, W. F. Clark, W. T. Sutherland, R. J. James, L. Thomas, M. A. B. Huxtable, C. R. 1991 http://dx.doi.org/10.1111/j.1748-5827.1991.tb00556.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-5827.1991.tb00556.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-5827.1991.tb00556.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Small Animal Practice volume 32, issue 5, page 241-248 ISSN 0022-4510 1748-5827 Small Animals journal-article 1991 crwiley https://doi.org/10.1111/j.1748-5827.1991.tb00556.x 2023-11-09T14:16:38Z Abstract A group of non‐azotaemic bull terriers from families with hereditary nephritis had significant subclinical renal disease. Of the renal function tests carried out, proteinuria, almost exclusively albumin, was a reliable and early indicator of glomerular abnormality. While 24‐hour urinary protein excretion (24 UPE) in the bull terriers was significantly higher than in a group of normal dogs of other breeds, urinary protein excretion (UPE) was also significantly higher when measured by simple single sample tests such as the urinary protein to urinary creatinine ratio (UP/C). UPE in bull terriers was correlated with increasing age, in contrast to lack of correlation in the normal dogs. The degree of proteinuria in affected bull terriers from which renal biopsies were taken correlated with the severity of histopathological changes which mainly affected glomeruli. Light microscopic examination revealed segmentally thickened glomerular and tubular basement membranes, thickened Bowman's capsules and adhesions between glomerular capillaries and Bowman's capsules. Other renal function tests were performed but failed to detect subclinical disease. It is suggested that hereditary nephritis (HN) in bull terriers is similar to that seen in samoyeds, dober‐mann pinschers and humans. Article in Journal/Newspaper samoyed* Wiley Online Library (via Crossref) Journal of Small Animal Practice 32 5 241 248 |
institution |
Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Small Animals |
spellingShingle |
Small Animals Hood, J. C. Robinson, W. F. Clark, W. T. Sutherland, R. J. James, L. Thomas, M. A. B. Huxtable, C. R. Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis |
topic_facet |
Small Animals |
description |
Abstract A group of non‐azotaemic bull terriers from families with hereditary nephritis had significant subclinical renal disease. Of the renal function tests carried out, proteinuria, almost exclusively albumin, was a reliable and early indicator of glomerular abnormality. While 24‐hour urinary protein excretion (24 UPE) in the bull terriers was significantly higher than in a group of normal dogs of other breeds, urinary protein excretion (UPE) was also significantly higher when measured by simple single sample tests such as the urinary protein to urinary creatinine ratio (UP/C). UPE in bull terriers was correlated with increasing age, in contrast to lack of correlation in the normal dogs. The degree of proteinuria in affected bull terriers from which renal biopsies were taken correlated with the severity of histopathological changes which mainly affected glomeruli. Light microscopic examination revealed segmentally thickened glomerular and tubular basement membranes, thickened Bowman's capsules and adhesions between glomerular capillaries and Bowman's capsules. Other renal function tests were performed but failed to detect subclinical disease. It is suggested that hereditary nephritis (HN) in bull terriers is similar to that seen in samoyeds, dober‐mann pinschers and humans. |
format |
Article in Journal/Newspaper |
author |
Hood, J. C. Robinson, W. F. Clark, W. T. Sutherland, R. J. James, L. Thomas, M. A. B. Huxtable, C. R. |
author_facet |
Hood, J. C. Robinson, W. F. Clark, W. T. Sutherland, R. J. James, L. Thomas, M. A. B. Huxtable, C. R. |
author_sort |
Hood, J. C. |
title |
Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis |
title_short |
Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis |
title_full |
Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis |
title_fullStr |
Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis |
title_full_unstemmed |
Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis |
title_sort |
proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis |
publisher |
Wiley |
publishDate |
1991 |
url |
http://dx.doi.org/10.1111/j.1748-5827.1991.tb00556.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-5827.1991.tb00556.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-5827.1991.tb00556.x |
genre |
samoyed* |
genre_facet |
samoyed* |
op_source |
Journal of Small Animal Practice volume 32, issue 5, page 241-248 ISSN 0022-4510 1748-5827 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1748-5827.1991.tb00556.x |
container_title |
Journal of Small Animal Practice |
container_volume |
32 |
container_issue |
5 |
container_start_page |
241 |
op_container_end_page |
248 |
_version_ |
1784255550684397568 |