Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women
In order to evaluate the role of the pineal gland in human reproduction, day‐ and nighttime concentrations of serum melatonin, FSH, LH and prolactin were measured by radioimmunoassays on various days of the menstrual cycle during summer (average daylight 22 h) and winter (daylight 5 h) in healthy fe...
Published in: | Acta Physiologica Scandinavica |
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crwiley:10.1111/j.1748-1716.1988.tb08335.x 2024-09-15T18:25:40+00:00 Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women KIVELÄ, A. KAUPPILA, A. YLÖSTALO, P. VAKKURI, O. LEPPÄLUOTO, J. 1988 http://dx.doi.org/10.1111/j.1748-1716.1988.tb08335.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-1716.1988.tb08335.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-1716.1988.tb08335.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Physiologica Scandinavica volume 132, issue 3, page 321-327 ISSN 0001-6772 1365-201X journal-article 1988 crwiley https://doi.org/10.1111/j.1748-1716.1988.tb08335.x 2024-08-20T04:14:00Z In order to evaluate the role of the pineal gland in human reproduction, day‐ and nighttime concentrations of serum melatonin, FSH, LH and prolactin were measured by radioimmunoassays on various days of the menstrual cycle during summer (average daylight 22 h) and winter (daylight 5 h) in healthy females ( n = 12) from northern Finland (65 o N). A multifactorial analysis of variance showed that, in addition to the well‐established increases of gonadotropins at midcycle and melatonin and prolactin at night, there was a significant effect of season on the serum levels of melatonin and LH. Night‐time serum melatonin levels on cycle days 2 and 10 were 27% and 49% ( P < 0.05 and < 0.01) higher in winter than in summer. Night‐time serum LH levels at midcycle were 76% ( P < 0.05) higher in summer than in winter. There were no significant effects of season on the serum levels of FSH, prolactin, day‐time melatonin or LH outside the mid‐cycle. Neither were there any significant effects of the day of the menstrual cycle on the serum melatonin levels. It is possible that in winter the high levels of melatonin in the follicular phase have an inhibitory effect on the serum LH levels. In summer the melatonin levels are lower and perhaps less inhibitory on the secretion of LH, resulting in the stimulation of the reproductive competence in human females. Article in Journal/Newspaper Northern Finland Wiley Online Library Acta Physiologica Scandinavica 132 3 321 327 |
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Wiley Online Library |
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English |
description |
In order to evaluate the role of the pineal gland in human reproduction, day‐ and nighttime concentrations of serum melatonin, FSH, LH and prolactin were measured by radioimmunoassays on various days of the menstrual cycle during summer (average daylight 22 h) and winter (daylight 5 h) in healthy females ( n = 12) from northern Finland (65 o N). A multifactorial analysis of variance showed that, in addition to the well‐established increases of gonadotropins at midcycle and melatonin and prolactin at night, there was a significant effect of season on the serum levels of melatonin and LH. Night‐time serum melatonin levels on cycle days 2 and 10 were 27% and 49% ( P < 0.05 and < 0.01) higher in winter than in summer. Night‐time serum LH levels at midcycle were 76% ( P < 0.05) higher in summer than in winter. There were no significant effects of season on the serum levels of FSH, prolactin, day‐time melatonin or LH outside the mid‐cycle. Neither were there any significant effects of the day of the menstrual cycle on the serum melatonin levels. It is possible that in winter the high levels of melatonin in the follicular phase have an inhibitory effect on the serum LH levels. In summer the melatonin levels are lower and perhaps less inhibitory on the secretion of LH, resulting in the stimulation of the reproductive competence in human females. |
format |
Article in Journal/Newspaper |
author |
KIVELÄ, A. KAUPPILA, A. YLÖSTALO, P. VAKKURI, O. LEPPÄLUOTO, J. |
spellingShingle |
KIVELÄ, A. KAUPPILA, A. YLÖSTALO, P. VAKKURI, O. LEPPÄLUOTO, J. Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women |
author_facet |
KIVELÄ, A. KAUPPILA, A. YLÖSTALO, P. VAKKURI, O. LEPPÄLUOTO, J. |
author_sort |
KIVELÄ, A. |
title |
Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women |
title_short |
Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women |
title_full |
Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women |
title_fullStr |
Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women |
title_full_unstemmed |
Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women |
title_sort |
seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women |
publisher |
Wiley |
publishDate |
1988 |
url |
http://dx.doi.org/10.1111/j.1748-1716.1988.tb08335.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-1716.1988.tb08335.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-1716.1988.tb08335.x |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Acta Physiologica Scandinavica volume 132, issue 3, page 321-327 ISSN 0001-6772 1365-201X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1748-1716.1988.tb08335.x |
container_title |
Acta Physiologica Scandinavica |
container_volume |
132 |
container_issue |
3 |
container_start_page |
321 |
op_container_end_page |
327 |
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1810466159759196160 |