Cardiac output and its distribution through capillaries and A‐V shunts in diving seals
Regional blood flow and cardiac output were determined by distribution of radioactive microspheres injected via catheter into the left ventricle during experimental diving and recovery in juvenile spotted seals ( Phoca vitulina largha ) and grey seals ( Halichoerus grypus ). Cardiac output was 9.7 L...
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crwiley:10.1111/j.1748-1716.1983.tb07250.x 2023-12-03T10:29:06+01:00 Cardiac output and its distribution through capillaries and A‐V shunts in diving seals BLIX, A. S. ELSNER, R. KJEKSHUS, J. K. 1983 http://dx.doi.org/10.1111/j.1748-1716.1983.tb07250.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-1716.1983.tb07250.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-1716.1983.tb07250.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Physiologica Scandinavica volume 118, issue 2, page 109-116 ISSN 0001-6772 1365-201X Physiology journal-article 1983 crwiley https://doi.org/10.1111/j.1748-1716.1983.tb07250.x 2023-11-09T14:30:21Z Regional blood flow and cardiac output were determined by distribution of radioactive microspheres injected via catheter into the left ventricle during experimental diving and recovery in juvenile spotted seals ( Phoca vitulina largha ) and grey seals ( Halichoerus grypus ). Cardiac output was 9.7 L/min before diving, declined 90% during submersion and increased to 12.1 L/min after 40 s of recovery. Left ventricular myocardial perfusion declined from 179 ± 24 (21) to 25 ± 2 (6) ml/min · 100 g at 2 min submersion, and measured 23 ± 3 (8) after 10 min of submersion. Cerebral cortical flow was reduced from a pre‐dive value of 115 ± 3 (15) to 40 ± 5 (3) and 49 ± 6 (3) at 2 and 5 min of diving, respectively, but increased to 253 ± 14 (4) ml/min · 100 g at 10 min along with elevated PCO 2 (84 torr) and lowered pH (7.10) in arterial blood. It remained at that level in recovery. Brain stem perfusion after 10 min submersion was still identical with control, but increased to 275% of control in recovery. Adrenal flow decreased to 34 and 27% of control at 2 and 5 min of diving, respectively. Recovery flow after 10 min of diving was 200% of control. Liver, kidney, fat, skin, and stomach were ischemic throughout the dive. Recovery flow increased slowly in these tissues. Skeletal muscle ( M. psoas ) was perfused at a low rate. (3 ml/min · 100 g) pre‐dive and was ischemic during diving. Recovery muscle perfusion was variable at different sites (from 5 to 105 ml/min · 100 g). Pre‐dive pulmonary capillary perfusion was 58 ± 8 (9) ml/min · 100 g, decreased to 7 ± 0 (3) ml/min · 100 g after 10 min of submersion, and had increased to 50% of pre‐dive value after 40 s of recovery from a 10 min dive. Conclusions are: (1) previous information from implanted flow transducers was confirmed, (2) detailed data for discrete tissues elaborate the concept of selective redistribution of cardiac output in diving seals, (3) non‐uniform reperfusion contributes to the maintenance of arterial presssure during recovery, and (4) substantial A‐V ... Article in Journal/Newspaper Phoca vitulina Wiley Online Library (via Crossref) Acta Physiologica Scandinavica 118 2 109 116 |
institution |
Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Physiology |
spellingShingle |
Physiology BLIX, A. S. ELSNER, R. KJEKSHUS, J. K. Cardiac output and its distribution through capillaries and A‐V shunts in diving seals |
topic_facet |
Physiology |
description |
Regional blood flow and cardiac output were determined by distribution of radioactive microspheres injected via catheter into the left ventricle during experimental diving and recovery in juvenile spotted seals ( Phoca vitulina largha ) and grey seals ( Halichoerus grypus ). Cardiac output was 9.7 L/min before diving, declined 90% during submersion and increased to 12.1 L/min after 40 s of recovery. Left ventricular myocardial perfusion declined from 179 ± 24 (21) to 25 ± 2 (6) ml/min · 100 g at 2 min submersion, and measured 23 ± 3 (8) after 10 min of submersion. Cerebral cortical flow was reduced from a pre‐dive value of 115 ± 3 (15) to 40 ± 5 (3) and 49 ± 6 (3) at 2 and 5 min of diving, respectively, but increased to 253 ± 14 (4) ml/min · 100 g at 10 min along with elevated PCO 2 (84 torr) and lowered pH (7.10) in arterial blood. It remained at that level in recovery. Brain stem perfusion after 10 min submersion was still identical with control, but increased to 275% of control in recovery. Adrenal flow decreased to 34 and 27% of control at 2 and 5 min of diving, respectively. Recovery flow after 10 min of diving was 200% of control. Liver, kidney, fat, skin, and stomach were ischemic throughout the dive. Recovery flow increased slowly in these tissues. Skeletal muscle ( M. psoas ) was perfused at a low rate. (3 ml/min · 100 g) pre‐dive and was ischemic during diving. Recovery muscle perfusion was variable at different sites (from 5 to 105 ml/min · 100 g). Pre‐dive pulmonary capillary perfusion was 58 ± 8 (9) ml/min · 100 g, decreased to 7 ± 0 (3) ml/min · 100 g after 10 min of submersion, and had increased to 50% of pre‐dive value after 40 s of recovery from a 10 min dive. Conclusions are: (1) previous information from implanted flow transducers was confirmed, (2) detailed data for discrete tissues elaborate the concept of selective redistribution of cardiac output in diving seals, (3) non‐uniform reperfusion contributes to the maintenance of arterial presssure during recovery, and (4) substantial A‐V ... |
format |
Article in Journal/Newspaper |
author |
BLIX, A. S. ELSNER, R. KJEKSHUS, J. K. |
author_facet |
BLIX, A. S. ELSNER, R. KJEKSHUS, J. K. |
author_sort |
BLIX, A. S. |
title |
Cardiac output and its distribution through capillaries and A‐V shunts in diving seals |
title_short |
Cardiac output and its distribution through capillaries and A‐V shunts in diving seals |
title_full |
Cardiac output and its distribution through capillaries and A‐V shunts in diving seals |
title_fullStr |
Cardiac output and its distribution through capillaries and A‐V shunts in diving seals |
title_full_unstemmed |
Cardiac output and its distribution through capillaries and A‐V shunts in diving seals |
title_sort |
cardiac output and its distribution through capillaries and a‐v shunts in diving seals |
publisher |
Wiley |
publishDate |
1983 |
url |
http://dx.doi.org/10.1111/j.1748-1716.1983.tb07250.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-1716.1983.tb07250.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-1716.1983.tb07250.x |
genre |
Phoca vitulina |
genre_facet |
Phoca vitulina |
op_source |
Acta Physiologica Scandinavica volume 118, issue 2, page 109-116 ISSN 0001-6772 1365-201X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1748-1716.1983.tb07250.x |
container_title |
Acta Physiologica Scandinavica |
container_volume |
118 |
container_issue |
2 |
container_start_page |
109 |
op_container_end_page |
116 |
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1784254243979395072 |