Drug Effects on Pre‐and Post‐branchial Blood Pressure and Heart Rate in a Free‐swimming Marine Teleost, Gadus morhua 1

Abstract Drug effects on pre‐and post‐branchial blood pressure and heart rate have been simultaneously and continuously registrated in free‐swimming cod (Gadus morhua). Adrenaline, noradrenaline and phenylephrine increased blood pressure, presumably by increasing systemic vascular resistance by alph...

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Published in:Acta Physiologica Scandinavica
Main Authors: Helgason, Sigurdur St., Nilsson, Stefan
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 1973
Subjects:
Online Access:http://dx.doi.org/10.1111/j.1748-1716.1973.tb05482.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-1716.1973.tb05482.x
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spelling crwiley:10.1111/j.1748-1716.1973.tb05482.x 2024-09-15T18:07:15+00:00 Drug Effects on Pre‐and Post‐branchial Blood Pressure and Heart Rate in a Free‐swimming Marine Teleost, Gadus morhua 1 Helgason, Sigurdur St. Nilsson, Stefan 1973 http://dx.doi.org/10.1111/j.1748-1716.1973.tb05482.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-1716.1973.tb05482.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-1716.1973.tb05482.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Physiologica Scandinavica volume 88, issue 4, page 533-540 ISSN 0001-6772 1365-201X journal-article 1973 crwiley https://doi.org/10.1111/j.1748-1716.1973.tb05482.x 2024-07-02T04:12:18Z Abstract Drug effects on pre‐and post‐branchial blood pressure and heart rate have been simultaneously and continuously registrated in free‐swimming cod (Gadus morhua). Adrenaline, noradrenaline and phenylephrine increased blood pressure, presumably by increasing systemic vascular resistance by alpha adrenergic stimulation. The heart rate was decreased by the same drugs, obviously by a baro‐receptor reflex, with the efferent inhibitory cholinergic fibres running in the vagus nerve. Yohimbine decreased the blood pressure and blocked the effect of adrenaline. The drop in blood pressure may be due to blockade of a normally acting vaso‐constrictor effect on the systemic vessels. Pre‐and post‐branchial blood pressure was reduced by isoprenaline, and this effect was reversed by propranolol, suggesting presence of adrenergic beta‐receptors in the systemic vascular bed. Propranolol also caused a drop in heart rate and post‐branchial blood pressure, while the pre‐branchial blood pressure was increased. This again could be due to abolishment of a normally acting adrenergic influence on the heart and branchial vessels. Article in Journal/Newspaper Gadus morhua Wiley Online Library Acta Physiologica Scandinavica 88 4 533 540
institution Open Polar
collection Wiley Online Library
op_collection_id crwiley
language English
description Abstract Drug effects on pre‐and post‐branchial blood pressure and heart rate have been simultaneously and continuously registrated in free‐swimming cod (Gadus morhua). Adrenaline, noradrenaline and phenylephrine increased blood pressure, presumably by increasing systemic vascular resistance by alpha adrenergic stimulation. The heart rate was decreased by the same drugs, obviously by a baro‐receptor reflex, with the efferent inhibitory cholinergic fibres running in the vagus nerve. Yohimbine decreased the blood pressure and blocked the effect of adrenaline. The drop in blood pressure may be due to blockade of a normally acting vaso‐constrictor effect on the systemic vessels. Pre‐and post‐branchial blood pressure was reduced by isoprenaline, and this effect was reversed by propranolol, suggesting presence of adrenergic beta‐receptors in the systemic vascular bed. Propranolol also caused a drop in heart rate and post‐branchial blood pressure, while the pre‐branchial blood pressure was increased. This again could be due to abolishment of a normally acting adrenergic influence on the heart and branchial vessels.
format Article in Journal/Newspaper
author Helgason, Sigurdur St.
Nilsson, Stefan
spellingShingle Helgason, Sigurdur St.
Nilsson, Stefan
Drug Effects on Pre‐and Post‐branchial Blood Pressure and Heart Rate in a Free‐swimming Marine Teleost, Gadus morhua 1
author_facet Helgason, Sigurdur St.
Nilsson, Stefan
author_sort Helgason, Sigurdur St.
title Drug Effects on Pre‐and Post‐branchial Blood Pressure and Heart Rate in a Free‐swimming Marine Teleost, Gadus morhua 1
title_short Drug Effects on Pre‐and Post‐branchial Blood Pressure and Heart Rate in a Free‐swimming Marine Teleost, Gadus morhua 1
title_full Drug Effects on Pre‐and Post‐branchial Blood Pressure and Heart Rate in a Free‐swimming Marine Teleost, Gadus morhua 1
title_fullStr Drug Effects on Pre‐and Post‐branchial Blood Pressure and Heart Rate in a Free‐swimming Marine Teleost, Gadus morhua 1
title_full_unstemmed Drug Effects on Pre‐and Post‐branchial Blood Pressure and Heart Rate in a Free‐swimming Marine Teleost, Gadus morhua 1
title_sort drug effects on pre‐and post‐branchial blood pressure and heart rate in a free‐swimming marine teleost, gadus morhua 1
publisher Wiley
publishDate 1973
url http://dx.doi.org/10.1111/j.1748-1716.1973.tb05482.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-1716.1973.tb05482.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-1716.1973.tb05482.x
genre Gadus morhua
genre_facet Gadus morhua
op_source Acta Physiologica Scandinavica
volume 88, issue 4, page 533-540
ISSN 0001-6772 1365-201X
op_rights http://onlinelibrary.wiley.com/termsAndConditions#vor
op_doi https://doi.org/10.1111/j.1748-1716.1973.tb05482.x
container_title Acta Physiologica Scandinavica
container_volume 88
container_issue 4
container_start_page 533
op_container_end_page 540
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