A SEARCH FOR ASSOCIATION BETWEEN IgD CONCENTRATIONS AND IMMUNOGLOBULIN ALLOTYPES IN 936 SERA FROM A GENETIC ISOLATE IN NEWFOUNDLAND

• Published in: European Journal of Immunogenetics
• Main Authors: Salimonu, L. S., Bryant, D. G., Lange, G. de, Marshall, W. H., Newton, R. M., Loghem, E. Van
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 1979
• Subjects: Genetics (clinical); Genetics; Molecular Biology; General Medicine; Immunology; Newfoundland
• Online Access: http://dx.doi.org/10.1111/j.1744-313x.1979.tb00338.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1744-313X.1979.tb00338.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1744-313X.1979.tb00338.x

Summary Immunoglobulin allotype (Gm) data has been analysed against immunoglobulin D (IgD) concentrations in a population study in Newfoundland. There was no significant difference between the distribution of IgD concentrations in people homozygous for the alleles Glm(f) and G3m(b) when compared with people homozygous for the alleles G1m(a) and G3m(g). These findings, involving 573 homozygous individuals as opposed to ninety‐eight in an earlier study on a New York population, do not confirm the earlier findings. Thus a genetic influence on IgD concentration by Gm genes or genes closely linked to them is not universally demonstrable by typing for these four markers and by using the Mancini technique for measuring IgD concentration.