Epstein‐Barr virus in exfoliated cells from the postnasal space
There is a high incidence of undifferentiated nasopharyngeal carcinoma (NCP) in certain populations, including Greenland Eskimos. The cancer appears to have a causal association with Epstein‐Barr virus (EBV), which is regularly found in NPC epithelial cells. With the aim of developing a method of sc...
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crwiley:10.1111/j.1699-0463.1994.tb04885.x 2024-03-31T07:52:35+00:00 Epstein‐Barr virus in exfoliated cells from the postnasal space Viral detection by polymerase chain reaction is not a useful means of screening for nasopharyngeal carcinoma in high‐risk populations HØRding, ULLA Albeck, HENRIK Katholm, MORTEN Kristensen, HENNING SUND 1994 http://dx.doi.org/10.1111/j.1699-0463.1994.tb04885.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1699-0463.1994.tb04885.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1699-0463.1994.tb04885.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor APMIS volume 102, issue 1-6, page 367-370 ISSN 0903-4641 1600-0463 Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine journal-article 1994 crwiley https://doi.org/10.1111/j.1699-0463.1994.tb04885.x 2024-03-04T13:02:32Z There is a high incidence of undifferentiated nasopharyngeal carcinoma (NCP) in certain populations, including Greenland Eskimos. The cancer appears to have a causal association with Epstein‐Barr virus (EBV), which is regularly found in NPC epithelial cells. With the aim of developing a method of screening or facilitating early diagnosis of NPC, we used the polymerase chain reaction to examine exfoliated nasopharyngeal cells for EBV in 54 Greenland and 17 white Danish subjects, none of whom was suspected of having NPC. EBV DNA was found in 81% of Greenland and 35% of Danish subjects. These findings support the concept of EBV infection leading in most cases to a chronic carrier state. It is concluded that EBV detection in nasopharyngeal cells is not at present a suitable method for identification of individuals at increased risk of developing NPC. Article in Journal/Newspaper eskimo* Greenland Wiley Online Library Greenland APMIS 102 1-6 367 370 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
topic |
Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine |
spellingShingle |
Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine HØRding, ULLA Albeck, HENRIK Katholm, MORTEN Kristensen, HENNING SUND Epstein‐Barr virus in exfoliated cells from the postnasal space |
topic_facet |
Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine |
description |
There is a high incidence of undifferentiated nasopharyngeal carcinoma (NCP) in certain populations, including Greenland Eskimos. The cancer appears to have a causal association with Epstein‐Barr virus (EBV), which is regularly found in NPC epithelial cells. With the aim of developing a method of screening or facilitating early diagnosis of NPC, we used the polymerase chain reaction to examine exfoliated nasopharyngeal cells for EBV in 54 Greenland and 17 white Danish subjects, none of whom was suspected of having NPC. EBV DNA was found in 81% of Greenland and 35% of Danish subjects. These findings support the concept of EBV infection leading in most cases to a chronic carrier state. It is concluded that EBV detection in nasopharyngeal cells is not at present a suitable method for identification of individuals at increased risk of developing NPC. |
format |
Article in Journal/Newspaper |
author |
HØRding, ULLA Albeck, HENRIK Katholm, MORTEN Kristensen, HENNING SUND |
author_facet |
HØRding, ULLA Albeck, HENRIK Katholm, MORTEN Kristensen, HENNING SUND |
author_sort |
HØRding, ULLA |
title |
Epstein‐Barr virus in exfoliated cells from the postnasal space |
title_short |
Epstein‐Barr virus in exfoliated cells from the postnasal space |
title_full |
Epstein‐Barr virus in exfoliated cells from the postnasal space |
title_fullStr |
Epstein‐Barr virus in exfoliated cells from the postnasal space |
title_full_unstemmed |
Epstein‐Barr virus in exfoliated cells from the postnasal space |
title_sort |
epstein‐barr virus in exfoliated cells from the postnasal space |
publisher |
Wiley |
publishDate |
1994 |
url |
http://dx.doi.org/10.1111/j.1699-0463.1994.tb04885.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1699-0463.1994.tb04885.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1699-0463.1994.tb04885.x |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland |
genre_facet |
eskimo* Greenland |
op_source |
APMIS volume 102, issue 1-6, page 367-370 ISSN 0903-4641 1600-0463 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1699-0463.1994.tb04885.x |
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APMIS |
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102 |
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1-6 |
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367 |
op_container_end_page |
370 |
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1795031795648954368 |