Factors associated with fatal outcome in childhood meningococcal disease
The purpose of this study was to identify factors associated with a fatal outcome in children with meningococcal disease and to design a new clinical scoring system. We reviewed the charts of all 137 children with meningococcal disease admitted alive to the University Hospital, Tromso, during the ye...
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crwiley:10.1111/j.1651-2227.1995.tb13513.x 2023-12-03T10:31:16+01:00 Factors associated with fatal outcome in childhood meningococcal disease Flaegstad, T Kaaresen, PI Stoklando, T Gutteberg, T 1995 http://dx.doi.org/10.1111/j.1651-2227.1995.tb13513.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1651-2227.1995.tb13513.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1651-2227.1995.tb13513.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Paediatrica volume 84, issue 10, page 1137-1142 ISSN 0803-5253 1651-2227 General Medicine Pediatrics, Perinatology and Child Health journal-article 1995 crwiley https://doi.org/10.1111/j.1651-2227.1995.tb13513.x 2023-11-09T13:40:55Z The purpose of this study was to identify factors associated with a fatal outcome in children with meningococcal disease and to design a new clinical scoring system. We reviewed the charts of all 137 children with meningococcal disease admitted alive to the University Hospital, Tromso, during the years 1977‐92. Twelve of the children died (8.7%). On admission the following clinical signs were significantly associated with poor outcome: peripheral vasoconstriction, cyanosis, extensive petechiae, hypotension, altered consciousness, hyperventilation and absence of neck rigidity. The laboratory parameters low pH, low base excess, thrombocytopenia, low Trombotest and leukopenia were also associated with later death. Multiple logistic regression was performed to examine the independent effect of each variable. Cyanosis, peripheral vasoconstriction and base excess– 10mmol/l or pH7.35 were significantly associated with a fatal outcome. A clinical scoring system based on the extent of petechiae, the presence of peripheral vasoconstriction, hyperventilation and/or cyanosis, the absence of neck rigidity and impairment of consciousness is proposed. Twenty‐nine patients received3.5 points, of whom 12 died and 12 survived. None of the patients who died had less than 3.5 points. The clinical scoring system is based solely on clinical signs. It can be done rapidly and performs well in identifying children who might benefit from early intensive care. Children, disease, meningitis, meningococci, prognostic score, sepsis Article in Journal/Newspaper Tromso Tromso Wiley Online Library (via Crossref) Tromso ENVELOPE(16.546,16.546,68.801,68.801) Acta Paediatrica 84 10 1137 1142 |
institution |
Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
General Medicine Pediatrics, Perinatology and Child Health |
spellingShingle |
General Medicine Pediatrics, Perinatology and Child Health Flaegstad, T Kaaresen, PI Stoklando, T Gutteberg, T Factors associated with fatal outcome in childhood meningococcal disease |
topic_facet |
General Medicine Pediatrics, Perinatology and Child Health |
description |
The purpose of this study was to identify factors associated with a fatal outcome in children with meningococcal disease and to design a new clinical scoring system. We reviewed the charts of all 137 children with meningococcal disease admitted alive to the University Hospital, Tromso, during the years 1977‐92. Twelve of the children died (8.7%). On admission the following clinical signs were significantly associated with poor outcome: peripheral vasoconstriction, cyanosis, extensive petechiae, hypotension, altered consciousness, hyperventilation and absence of neck rigidity. The laboratory parameters low pH, low base excess, thrombocytopenia, low Trombotest and leukopenia were also associated with later death. Multiple logistic regression was performed to examine the independent effect of each variable. Cyanosis, peripheral vasoconstriction and base excess– 10mmol/l or pH7.35 were significantly associated with a fatal outcome. A clinical scoring system based on the extent of petechiae, the presence of peripheral vasoconstriction, hyperventilation and/or cyanosis, the absence of neck rigidity and impairment of consciousness is proposed. Twenty‐nine patients received3.5 points, of whom 12 died and 12 survived. None of the patients who died had less than 3.5 points. The clinical scoring system is based solely on clinical signs. It can be done rapidly and performs well in identifying children who might benefit from early intensive care. Children, disease, meningitis, meningococci, prognostic score, sepsis |
format |
Article in Journal/Newspaper |
author |
Flaegstad, T Kaaresen, PI Stoklando, T Gutteberg, T |
author_facet |
Flaegstad, T Kaaresen, PI Stoklando, T Gutteberg, T |
author_sort |
Flaegstad, T |
title |
Factors associated with fatal outcome in childhood meningococcal disease |
title_short |
Factors associated with fatal outcome in childhood meningococcal disease |
title_full |
Factors associated with fatal outcome in childhood meningococcal disease |
title_fullStr |
Factors associated with fatal outcome in childhood meningococcal disease |
title_full_unstemmed |
Factors associated with fatal outcome in childhood meningococcal disease |
title_sort |
factors associated with fatal outcome in childhood meningococcal disease |
publisher |
Wiley |
publishDate |
1995 |
url |
http://dx.doi.org/10.1111/j.1651-2227.1995.tb13513.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1651-2227.1995.tb13513.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1651-2227.1995.tb13513.x |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso |
geographic_facet |
Tromso |
genre |
Tromso Tromso |
genre_facet |
Tromso Tromso |
op_source |
Acta Paediatrica volume 84, issue 10, page 1137-1142 ISSN 0803-5253 1651-2227 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1651-2227.1995.tb13513.x |
container_title |
Acta Paediatrica |
container_volume |
84 |
container_issue |
10 |
container_start_page |
1137 |
op_container_end_page |
1142 |
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1784257480201601024 |