Epstein‐Barr Virus Infection and Serological Profile in Greenland Eskimo Children
ABSTRACT. The Epstein‐Barr virus (EBV)‐specific antibody profile of 101 Greenland Eskimo children was determined. The proportion of children with serological evidence of recent or past primary EBV infections rose from 22 % at 6 months of age to 79 % at 24 months of age. All but 2 of 49 children more...
Published in: | Acta Paediatrica |
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Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
1985
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Subjects: | |
Online Access: | http://dx.doi.org/10.1111/j.1651-2227.1985.tb10015.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1651-2227.1985.tb10015.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1651-2227.1985.tb10015.x |
Summary: | ABSTRACT. The Epstein‐Barr virus (EBV)‐specific antibody profile of 101 Greenland Eskimo children was determined. The proportion of children with serological evidence of recent or past primary EBV infections rose from 22 % at 6 months of age to 79 % at 24 months of age. All but 2 of 49 children more than 4 years of age proved seropositive. The geometric mean titre (GMT) of antibodies to the viral capsid antigen (VCA) was highest during the first 3 years of life and declined sharply to a lower, nearly constant level in older children. The GMT of antibodies to the nuclear antigen (EBNA), rose slowly during the first 4 years of life to its persistent level. None of the children had a history of illnesses comparable to infectious mononucleosis. The results have shown that in this population with an enhanced risk of nasopharyngeal carcinoma, primary EBV infection occurs at a very early age. |
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