Quantitative and Qualitative Distribution of Mercury in Organs from Arctic Sledgedogs: An Atomic Absorption Spectrophotometric and Histochemical Study of Tissue Samples from Natural Long‐Termed High Dietary Organic Mercury‐Exposed Dogs from Thule, Greenland
Abstract: Organs from 10 sledgedogs fed methyl mercury‐containing organs and meat from predatory marine animals also eaten by humans in the Thule district of Greenland, were examined histochemically for cellular distribution of mercury, and the organ concentrations of mercury were quantified by atom...
Published in: | Pharmacology & Toxicology |
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crwiley:10.1111/j.1600-0773.1995.tb01011.x 2023-12-03T10:17:24+01:00 Quantitative and Qualitative Distribution of Mercury in Organs from Arctic Sledgedogs: An Atomic Absorption Spectrophotometric and Histochemical Study of Tissue Samples from Natural Long‐Termed High Dietary Organic Mercury‐Exposed Dogs from Thule, Greenland Hansen, Jens C. Danscher, Gorm 1995 http://dx.doi.org/10.1111/j.1600-0773.1995.tb01011.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0773.1995.tb01011.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0773.1995.tb01011.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Pharmacology & Toxicology volume 77, issue 3, page 189-195 ISSN 0901-9928 Health, Toxicology and Mutagenesis Pharmacology Toxicology journal-article 1995 crwiley https://doi.org/10.1111/j.1600-0773.1995.tb01011.x 2023-11-09T14:15:58Z Abstract: Organs from 10 sledgedogs fed methyl mercury‐containing organs and meat from predatory marine animals also eaten by humans in the Thule district of Greenland, were examined histochemically for cellular distribution of mercury, and the organ concentrations of mercury were quantified by atomic absorption spectrometry (total Hg). In selected organs the methyl mercuric level was determined by gaschromatography. The highest concentration of total mercury was found in mesenterial lymph nodes followed by liver and kidneys, which indicates that the lymphatic system might play an important role in the regulating transport of mercury to target organs. The concentrations were age‐related, and the results suggest that demethylation takes place in all organs except skeletal muscles, but lowest in CNS. The distribution of mercury at cellular and subcellular levels was studied by the autometallographic technique. The atomic absorption spectrometric and autometallographic results were in good agreement. The brain mean concentration in the oldest group was 438 μg/kg, a level much lower than what has been reported to cause effects in the human central nervous system. However, if humans over a period of e.g. 50 years eat Arctic marine meat and accumulate mercury in the same way as dogs, the possibility that this may have health implications cannot be entirely excluded. Article in Journal/Newspaper Arctic Greenland Thule Wiley Online Library (via Crossref) Arctic Greenland Pharmacology & Toxicology 77 3 189 195 |
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Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Health, Toxicology and Mutagenesis Pharmacology Toxicology |
spellingShingle |
Health, Toxicology and Mutagenesis Pharmacology Toxicology Hansen, Jens C. Danscher, Gorm Quantitative and Qualitative Distribution of Mercury in Organs from Arctic Sledgedogs: An Atomic Absorption Spectrophotometric and Histochemical Study of Tissue Samples from Natural Long‐Termed High Dietary Organic Mercury‐Exposed Dogs from Thule, Greenland |
topic_facet |
Health, Toxicology and Mutagenesis Pharmacology Toxicology |
description |
Abstract: Organs from 10 sledgedogs fed methyl mercury‐containing organs and meat from predatory marine animals also eaten by humans in the Thule district of Greenland, were examined histochemically for cellular distribution of mercury, and the organ concentrations of mercury were quantified by atomic absorption spectrometry (total Hg). In selected organs the methyl mercuric level was determined by gaschromatography. The highest concentration of total mercury was found in mesenterial lymph nodes followed by liver and kidneys, which indicates that the lymphatic system might play an important role in the regulating transport of mercury to target organs. The concentrations were age‐related, and the results suggest that demethylation takes place in all organs except skeletal muscles, but lowest in CNS. The distribution of mercury at cellular and subcellular levels was studied by the autometallographic technique. The atomic absorption spectrometric and autometallographic results were in good agreement. The brain mean concentration in the oldest group was 438 μg/kg, a level much lower than what has been reported to cause effects in the human central nervous system. However, if humans over a period of e.g. 50 years eat Arctic marine meat and accumulate mercury in the same way as dogs, the possibility that this may have health implications cannot be entirely excluded. |
format |
Article in Journal/Newspaper |
author |
Hansen, Jens C. Danscher, Gorm |
author_facet |
Hansen, Jens C. Danscher, Gorm |
author_sort |
Hansen, Jens C. |
title |
Quantitative and Qualitative Distribution of Mercury in Organs from Arctic Sledgedogs: An Atomic Absorption Spectrophotometric and Histochemical Study of Tissue Samples from Natural Long‐Termed High Dietary Organic Mercury‐Exposed Dogs from Thule, Greenland |
title_short |
Quantitative and Qualitative Distribution of Mercury in Organs from Arctic Sledgedogs: An Atomic Absorption Spectrophotometric and Histochemical Study of Tissue Samples from Natural Long‐Termed High Dietary Organic Mercury‐Exposed Dogs from Thule, Greenland |
title_full |
Quantitative and Qualitative Distribution of Mercury in Organs from Arctic Sledgedogs: An Atomic Absorption Spectrophotometric and Histochemical Study of Tissue Samples from Natural Long‐Termed High Dietary Organic Mercury‐Exposed Dogs from Thule, Greenland |
title_fullStr |
Quantitative and Qualitative Distribution of Mercury in Organs from Arctic Sledgedogs: An Atomic Absorption Spectrophotometric and Histochemical Study of Tissue Samples from Natural Long‐Termed High Dietary Organic Mercury‐Exposed Dogs from Thule, Greenland |
title_full_unstemmed |
Quantitative and Qualitative Distribution of Mercury in Organs from Arctic Sledgedogs: An Atomic Absorption Spectrophotometric and Histochemical Study of Tissue Samples from Natural Long‐Termed High Dietary Organic Mercury‐Exposed Dogs from Thule, Greenland |
title_sort |
quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long‐termed high dietary organic mercury‐exposed dogs from thule, greenland |
publisher |
Wiley |
publishDate |
1995 |
url |
http://dx.doi.org/10.1111/j.1600-0773.1995.tb01011.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0773.1995.tb01011.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0773.1995.tb01011.x |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Greenland Thule |
genre_facet |
Arctic Greenland Thule |
op_source |
Pharmacology & Toxicology volume 77, issue 3, page 189-195 ISSN 0901-9928 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1600-0773.1995.tb01011.x |
container_title |
Pharmacology & Toxicology |
container_volume |
77 |
container_issue |
3 |
container_start_page |
189 |
op_container_end_page |
195 |
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1784264363299831808 |