The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes
Summary: The immunoglobulin heavy chain locus in teleost fish is structurally similar to that in mammals, comprising a series of variable gene segments upstream of two constant region genes coding for IgM and IgD. Atlantic salmon have been shown to possess two distinct heavy chain loci, related to t...
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crwiley:10.1111/j.1600-065x.1998.tb01260.x 2024-06-23T07:51:14+00:00 The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes Hordvik, Ivar 1998 http://dx.doi.org/10.1111/j.1600-065x.1998.tb01260.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-065X.1998.tb01260.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-065X.1998.tb01260.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Immunological Reviews volume 166, issue 1, page 153-157 ISSN 0105-2896 1600-065X journal-article 1998 crwiley https://doi.org/10.1111/j.1600-065x.1998.tb01260.x 2024-06-06T04:22:04Z Summary: The immunoglobulin heavy chain locus in teleost fish is structurally similar to that in mammals, comprising a series of variable gene segments upstream of two constant region genes coding for IgM and IgD. Atlantic salmon have been shown to possess two distinct heavy chain loci, related to the tetraploid ancestry of this fish family. The nature (and results) of the evolutionary processes following the tetraploidization event are the focus of this review. Salmonid fish did not return quickly to a diploid state, but are still in the process of re‐establishing disomic inheritance. Thus, a specific locus in one species may still be endowed with four alleles, while it may have been converted to a pair of isoloci in another species. Analyses of immunoglobulin heavy chain genes in Atlantic salmon (Salmo salar) have strongly indicated that the ancestral heavy chain locus was subjected to tetrasomy throughout the radiation of the genera Oncorhynchus and Salmo, and that disomic inheritance was established in the Salmo lineage in the comparatively recent past. The introduction of disomic inheritance at these loci has resulted in two subsets of IgM and IgD heavy chains in Atlantic salmon. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library Immunological Reviews 166 1 153 157 |
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Wiley Online Library |
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English |
description |
Summary: The immunoglobulin heavy chain locus in teleost fish is structurally similar to that in mammals, comprising a series of variable gene segments upstream of two constant region genes coding for IgM and IgD. Atlantic salmon have been shown to possess two distinct heavy chain loci, related to the tetraploid ancestry of this fish family. The nature (and results) of the evolutionary processes following the tetraploidization event are the focus of this review. Salmonid fish did not return quickly to a diploid state, but are still in the process of re‐establishing disomic inheritance. Thus, a specific locus in one species may still be endowed with four alleles, while it may have been converted to a pair of isoloci in another species. Analyses of immunoglobulin heavy chain genes in Atlantic salmon (Salmo salar) have strongly indicated that the ancestral heavy chain locus was subjected to tetrasomy throughout the radiation of the genera Oncorhynchus and Salmo, and that disomic inheritance was established in the Salmo lineage in the comparatively recent past. The introduction of disomic inheritance at these loci has resulted in two subsets of IgM and IgD heavy chains in Atlantic salmon. |
format |
Article in Journal/Newspaper |
author |
Hordvik, Ivar |
spellingShingle |
Hordvik, Ivar The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes |
author_facet |
Hordvik, Ivar |
author_sort |
Hordvik, Ivar |
title |
The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes |
title_short |
The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes |
title_full |
The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes |
title_fullStr |
The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes |
title_full_unstemmed |
The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes |
title_sort |
impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes |
publisher |
Wiley |
publishDate |
1998 |
url |
http://dx.doi.org/10.1111/j.1600-065x.1998.tb01260.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-065X.1998.tb01260.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-065X.1998.tb01260.x |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Immunological Reviews volume 166, issue 1, page 153-157 ISSN 0105-2896 1600-065X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1600-065x.1998.tb01260.x |
container_title |
Immunological Reviews |
container_volume |
166 |
container_issue |
1 |
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153 |
op_container_end_page |
157 |
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1802642252623773696 |