Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing
Abstract: Bathing in the Blue Lagoon, a specific geothermal biotope in Iceland has been known for many years to be beneficial for human skin in general and for patients with psoriasis and atopic dermatitis in particular. The scientific rationale for this empirical observation, however has remained e...
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crwiley:10.1111/j.1600-0625.2007.00693.x 2024-09-15T18:14:18+00:00 Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing Grether‐Beck, Susanne Mühlberg, Kathrin Brenden, Heidi Felsner, Ingo Brynjólfsdóttir, Ása Einarsson, Sigurbjörn Krutmann, Jean 2008 http://dx.doi.org/10.1111/j.1600-0625.2007.00693.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0625.2007.00693.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0625.2007.00693.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Experimental Dermatology volume 17, issue 9, page 771-779 ISSN 0906-6705 1600-0625 journal-article 2008 crwiley https://doi.org/10.1111/j.1600-0625.2007.00693.x 2024-08-09T04:25:45Z Abstract: Bathing in the Blue Lagoon, a specific geothermal biotope in Iceland has been known for many years to be beneficial for human skin in general and for patients with psoriasis and atopic dermatitis in particular. The scientific rationale for this empirical observation, however has remained elusive. We now report that extracts prepared from silica mud and two different microalgae species derived from the Blue Lagoon are capable of inducing involucrin, loricrin, transglutaminase‐1 and filaggrin gene expression in primary human epidermal keratinocytes. The same extracts also affects primary human dermal fibroblasts, because extracts from silica mud and one type of algae inhibited UVA radiation‐induced upregulation of matrix metalloproteinase‐1 expression and both algae, as well as silica mud extracts induced collagen 1A1 and 1A2 gene expression in this cell type. These effects were not restricted to the in vitro situation because topical treatment of healthy human skin ( n = 20) with a galenic formulation containing all three extracts induced identical gene regulatory effects in vivo , which were associated with a significant reduction of transepidermal water loss. In aggregate, these results suggest that the bioactives in Blue Lagoon have the capacity to improve skin barrier function and to prevent premature skin ageing. These observations explain at least some of the beneficial effects of bathing in the Blue Lagoon and provide a scientific basis for the use of Blue Lagoon extracts in cosmetic and/or medical products. Article in Journal/Newspaper Iceland Wiley Online Library Experimental Dermatology 17 9 771 779 |
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English |
description |
Abstract: Bathing in the Blue Lagoon, a specific geothermal biotope in Iceland has been known for many years to be beneficial for human skin in general and for patients with psoriasis and atopic dermatitis in particular. The scientific rationale for this empirical observation, however has remained elusive. We now report that extracts prepared from silica mud and two different microalgae species derived from the Blue Lagoon are capable of inducing involucrin, loricrin, transglutaminase‐1 and filaggrin gene expression in primary human epidermal keratinocytes. The same extracts also affects primary human dermal fibroblasts, because extracts from silica mud and one type of algae inhibited UVA radiation‐induced upregulation of matrix metalloproteinase‐1 expression and both algae, as well as silica mud extracts induced collagen 1A1 and 1A2 gene expression in this cell type. These effects were not restricted to the in vitro situation because topical treatment of healthy human skin ( n = 20) with a galenic formulation containing all three extracts induced identical gene regulatory effects in vivo , which were associated with a significant reduction of transepidermal water loss. In aggregate, these results suggest that the bioactives in Blue Lagoon have the capacity to improve skin barrier function and to prevent premature skin ageing. These observations explain at least some of the beneficial effects of bathing in the Blue Lagoon and provide a scientific basis for the use of Blue Lagoon extracts in cosmetic and/or medical products. |
format |
Article in Journal/Newspaper |
author |
Grether‐Beck, Susanne Mühlberg, Kathrin Brenden, Heidi Felsner, Ingo Brynjólfsdóttir, Ása Einarsson, Sigurbjörn Krutmann, Jean |
spellingShingle |
Grether‐Beck, Susanne Mühlberg, Kathrin Brenden, Heidi Felsner, Ingo Brynjólfsdóttir, Ása Einarsson, Sigurbjörn Krutmann, Jean Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing |
author_facet |
Grether‐Beck, Susanne Mühlberg, Kathrin Brenden, Heidi Felsner, Ingo Brynjólfsdóttir, Ása Einarsson, Sigurbjörn Krutmann, Jean |
author_sort |
Grether‐Beck, Susanne |
title |
Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing |
title_short |
Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing |
title_full |
Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing |
title_fullStr |
Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing |
title_full_unstemmed |
Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing |
title_sort |
bioactive molecules from the blue lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing |
publisher |
Wiley |
publishDate |
2008 |
url |
http://dx.doi.org/10.1111/j.1600-0625.2007.00693.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0625.2007.00693.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0625.2007.00693.x |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Experimental Dermatology volume 17, issue 9, page 771-779 ISSN 0906-6705 1600-0625 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1600-0625.2007.00693.x |
container_title |
Experimental Dermatology |
container_volume |
17 |
container_issue |
9 |
container_start_page |
771 |
op_container_end_page |
779 |
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1810452073424093184 |