Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population
Objective: This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia. Method: Using 134 family trios with a history of psychosis, we genotyped six of the...
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crwiley:10.1111/j.1600-0447.2005.00631.x 2023-12-03T10:24:51+01:00 Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population Walss‐Bass, C. Raventos, H. Montero, A. P. Armas, R. Dassori, A. Contreras, S. Liu, W. Medina, R. Levinson, D. F. Pereira, M. Leach, R. J. Almasy, L. Escamilla, M. A. 2005 http://dx.doi.org/10.1111/j.1600-0447.2005.00631.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0447.2005.00631.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0447.2005.00631.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Psychiatrica Scandinavica volume 113, issue 4, page 314-321 ISSN 0001-690X 1600-0447 Psychiatry and Mental health journal-article 2005 crwiley https://doi.org/10.1111/j.1600-0447.2005.00631.x 2023-11-09T14:35:31Z Objective: This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia. Method: Using 134 family trios with a history of psychosis, we genotyped six of the seven markers originally identified to be associated with schizophrenia in Iceland. Results: The neuregulin Icelandic haplotype was not associated with schizophrenia in the CVCR population. However, a novel haplotype was found to be overrepresented in subjects with functional psychosis (global P ‐value > 0.05). Stratification of the sample by history of mania suggests that this haplotype may be preferentially over‐transmitted to persons with a history of manic psychosis. Conclusion: These results suggest that the neuregulin 1 gene is unlikely to play a major role in predisposing to schizophrenia in the CVCR. Further studies in the CVCR and other Latin American populations should be performed in order to corroborate these findings. Article in Journal/Newspaper Iceland Wiley Online Library (via Crossref) Acta Psychiatrica Scandinavica 113 4 314 321 |
institution |
Open Polar |
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Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Psychiatry and Mental health |
spellingShingle |
Psychiatry and Mental health Walss‐Bass, C. Raventos, H. Montero, A. P. Armas, R. Dassori, A. Contreras, S. Liu, W. Medina, R. Levinson, D. F. Pereira, M. Leach, R. J. Almasy, L. Escamilla, M. A. Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population |
topic_facet |
Psychiatry and Mental health |
description |
Objective: This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia. Method: Using 134 family trios with a history of psychosis, we genotyped six of the seven markers originally identified to be associated with schizophrenia in Iceland. Results: The neuregulin Icelandic haplotype was not associated with schizophrenia in the CVCR population. However, a novel haplotype was found to be overrepresented in subjects with functional psychosis (global P ‐value > 0.05). Stratification of the sample by history of mania suggests that this haplotype may be preferentially over‐transmitted to persons with a history of manic psychosis. Conclusion: These results suggest that the neuregulin 1 gene is unlikely to play a major role in predisposing to schizophrenia in the CVCR. Further studies in the CVCR and other Latin American populations should be performed in order to corroborate these findings. |
format |
Article in Journal/Newspaper |
author |
Walss‐Bass, C. Raventos, H. Montero, A. P. Armas, R. Dassori, A. Contreras, S. Liu, W. Medina, R. Levinson, D. F. Pereira, M. Leach, R. J. Almasy, L. Escamilla, M. A. |
author_facet |
Walss‐Bass, C. Raventos, H. Montero, A. P. Armas, R. Dassori, A. Contreras, S. Liu, W. Medina, R. Levinson, D. F. Pereira, M. Leach, R. J. Almasy, L. Escamilla, M. A. |
author_sort |
Walss‐Bass, C. |
title |
Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population |
title_short |
Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population |
title_full |
Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population |
title_fullStr |
Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population |
title_full_unstemmed |
Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population |
title_sort |
association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a hispanic population |
publisher |
Wiley |
publishDate |
2005 |
url |
http://dx.doi.org/10.1111/j.1600-0447.2005.00631.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0447.2005.00631.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0447.2005.00631.x |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Acta Psychiatrica Scandinavica volume 113, issue 4, page 314-321 ISSN 0001-690X 1600-0447 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1600-0447.2005.00631.x |
container_title |
Acta Psychiatrica Scandinavica |
container_volume |
113 |
container_issue |
4 |
container_start_page |
314 |
op_container_end_page |
321 |
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1784273435667464192 |