Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway
ABSTRACT – Forty‐three outpatients with “midwinter insomnia” (an early type insomnia commonly seen north of the Polar Circle when the sun stays below the horizon) were randomly allocated to one of three treatment groups, receiving either 15 mg midazolam, 1 mg flunitrazepam, or placebo, for 5 nights,...
Published in: | Acta Psychiatrica Scandinavica |
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crwiley:10.1111/j.1600-0447.1983.tb06731.x 2023-12-03T10:27:51+01:00 Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway Lingjærde, O. Bratlid, T. Westby, O. C. Gordeladze, J. O. 1983 http://dx.doi.org/10.1111/j.1600-0447.1983.tb06731.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0447.1983.tb06731.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0447.1983.tb06731.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Psychiatrica Scandinavica volume 67, issue 2, page 118-129 ISSN 0001-690X 1600-0447 Psychiatry and Mental health journal-article 1983 crwiley https://doi.org/10.1111/j.1600-0447.1983.tb06731.x 2023-11-09T14:35:17Z ABSTRACT – Forty‐three outpatients with “midwinter insomnia” (an early type insomnia commonly seen north of the Polar Circle when the sun stays below the horizon) were randomly allocated to one of three treatment groups, receiving either 15 mg midazolam, 1 mg flunitrazepam, or placebo, for 5 nights, double blind, after 3 nights without drug. In all three groups, this was followed by 5 nights on placebo (single blind). Several subjective sleep variables were recorded every morning, some variables also at noon. Placebo had practically no effect on any sleep variable, whereas both active drugs markedly improved sleep with regard to the following variables: sleep latency, number of awakenings, total duration of sleep, quality of sleep, total evaluation of sleep, and feelings of drowsiness in the morning and at noon. In the withdrawal period, patients who had Received active drug showed a deterioration of sleep on most variables, but not beyond the baseline level. A true “rebound insomnia” could thus not be demonstrated. There was no significant difference in any of the variables between midazolam and flunitrazepam treatment. Side effects were reported by very few patients. Midazolam seems to be as effective as flunitrazepam in this type of insomnia, in spite of its much shorter biological half‐life. Article in Journal/Newspaper Northern Norway Wiley Online Library (via Crossref) Midwinter ENVELOPE(139.931,139.931,-66.690,-66.690) Norway Acta Psychiatrica Scandinavica 67 2 118 129 |
institution |
Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Psychiatry and Mental health |
spellingShingle |
Psychiatry and Mental health Lingjærde, O. Bratlid, T. Westby, O. C. Gordeladze, J. O. Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway |
topic_facet |
Psychiatry and Mental health |
description |
ABSTRACT – Forty‐three outpatients with “midwinter insomnia” (an early type insomnia commonly seen north of the Polar Circle when the sun stays below the horizon) were randomly allocated to one of three treatment groups, receiving either 15 mg midazolam, 1 mg flunitrazepam, or placebo, for 5 nights, double blind, after 3 nights without drug. In all three groups, this was followed by 5 nights on placebo (single blind). Several subjective sleep variables were recorded every morning, some variables also at noon. Placebo had practically no effect on any sleep variable, whereas both active drugs markedly improved sleep with regard to the following variables: sleep latency, number of awakenings, total duration of sleep, quality of sleep, total evaluation of sleep, and feelings of drowsiness in the morning and at noon. In the withdrawal period, patients who had Received active drug showed a deterioration of sleep on most variables, but not beyond the baseline level. A true “rebound insomnia” could thus not be demonstrated. There was no significant difference in any of the variables between midazolam and flunitrazepam treatment. Side effects were reported by very few patients. Midazolam seems to be as effective as flunitrazepam in this type of insomnia, in spite of its much shorter biological half‐life. |
format |
Article in Journal/Newspaper |
author |
Lingjærde, O. Bratlid, T. Westby, O. C. Gordeladze, J. O. |
author_facet |
Lingjærde, O. Bratlid, T. Westby, O. C. Gordeladze, J. O. |
author_sort |
Lingjærde, O. |
title |
Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway |
title_short |
Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway |
title_full |
Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway |
title_fullStr |
Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway |
title_full_unstemmed |
Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway |
title_sort |
effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern norway |
publisher |
Wiley |
publishDate |
1983 |
url |
http://dx.doi.org/10.1111/j.1600-0447.1983.tb06731.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0447.1983.tb06731.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0447.1983.tb06731.x |
long_lat |
ENVELOPE(139.931,139.931,-66.690,-66.690) |
geographic |
Midwinter Norway |
geographic_facet |
Midwinter Norway |
genre |
Northern Norway |
genre_facet |
Northern Norway |
op_source |
Acta Psychiatrica Scandinavica volume 67, issue 2, page 118-129 ISSN 0001-690X 1600-0447 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1600-0447.1983.tb06731.x |
container_title |
Acta Psychiatrica Scandinavica |
container_volume |
67 |
container_issue |
2 |
container_start_page |
118 |
op_container_end_page |
129 |
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1784277764520542208 |