3 Tesla MRI‐Detected Brain Lesions after Pulmonary Vein Isolation for Atrial Fibrillation: Results of the MACPAF Study

• Published in: Journal of Cardiovascular Electrophysiology
• Main Authors: HAEUSLER, KARL GEORG, KOCH, LYDIA, HERM, JULIANE, KOPP, UTE A., HEUSCHMANN, PETER U., ENDRES, MATTHIAS, SCHULTHEISS, HEINZ‐PETER, SCHIRDEWAN, ALEXANDER, FIEBACH, JOCHEN B.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2012
• Subjects: Arctic
• Online Access: http://dx.doi.org/10.1111/j.1540-8167.2012.02420.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1540-8167.2012.02420.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1540-8167.2012.02420.x

MRI Results of the MACPAF Study. Background: Left atrial catheter ablation (LACA) is an established therapeutic approach to abolish symptomatic atrial fibrillation (AF). Objective: Based on the prospective MACPAF study (clinicaltrials.gov NCT01061931) we report the rate of ischemic brain lesions postablation and their impact on cognitive function. Methods: Patients with symptomatic paroxysmal AF were randomized to LACA using the Arctic Front® or the HD Mesh Ablator® catheter. All patients underwent brain MRI at 3 Tesla, neurological, and neuropsychological examinations within 48 hours prior and after the ablation procedure. Results: There was no clinically evident stroke in 37 patients (mean age 62.4 ± 8.4 years; 41% female; median CHADS2 score 1 [IQR 0–2]) after LACA but high‐resolution diffusion‐weighted imaging (DWI) detected new ischemic lesions in 15 (41%) patients after LACA. Four (27%) of the HD Mesh Ablator® patients and 11 (50%) of the Arctic Front® patients suffered a silent ischemic lesion (P = 0.19). In these 15 patients, there was a nonsignificant trend toward lower cardiac ejection fraction (P = 0.07) and AF episodes during LACA (P = 0.09), while activated clotting time levels, number of energy applications, periprocedural electrocardioversion or CHADS 2 score had no impact. Lesion volumes varied from 5 to 150 mm 3 and 1 to 5 lesions were detected per patient. However, acute brain lesions had no effect on cognitive performance immediately after LACA. Of the DWI lesions postablation 82% were not detectable on FLAIR images 6–9 months postablation. Conclusions: According to 3 Tesla high‐resolution DWI, ischemic brain lesions after LACA were common but not associated with impaired cognitive function after the ablation procedure. (J Cardiovasc Electrophysiol, Vol. 24, pp. 14‐21, January 2013)