Helicobacter pylori Infection, Intestinal Metaplasia, and Gastric Cancer Risk in Eastern Siberia
Abstract Background: The incidence of gastric cancer (GC) is extremely high in Russia and eastern Siberia, where information on the epidemiology of Helicobacter pylori infection is fragmentary. Aims: To assess the prevalence of both H. pylori infection (including CagA status) and intestinal metaplas...
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crwiley:10.1111/j.1523-5378.2011.00827.x 2024-06-23T07:52:35+00:00 Helicobacter pylori Infection, Intestinal Metaplasia, and Gastric Cancer Risk in Eastern Siberia Tsukanov, Vladislav Vladimirovich Butorin, Nikolai Nikolaevich Maady, Ayas Sergeevich Shtygasheva, Olga Vladimirovna Amelchugova, Olga Sergeevna Tonkikh, Julia Leongardovna Fassan, Matteo Rugge, Massimo 2011 http://dx.doi.org/10.1111/j.1523-5378.2011.00827.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1523-5378.2011.00827.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1523-5378.2011.00827.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Helicobacter volume 16, issue 2, page 107-112 ISSN 1083-4389 1523-5378 journal-article 2011 crwiley https://doi.org/10.1111/j.1523-5378.2011.00827.x 2024-06-13T04:23:06Z Abstract Background: The incidence of gastric cancer (GC) is extremely high in Russia and eastern Siberia, where information on the epidemiology of Helicobacter pylori infection is fragmentary. Aims: To assess the prevalence of both H. pylori infection (including CagA status) and intestinal metaplasia (IM) in Russian and eastern Siberian populations carrying a different risk of GC. Materials and Methods: A sample of 2129 consecutive patients was considered, including 689 Europoids and 1440 Mongoloids (493 Evenks, 533 Khakass people, and 414 Tuvans), who all underwent serum sampling and upper gastrointestinal endoscopy. H. pylori status was established (ELISA, urease test, and histology), and IgG anti‐CagA antibodies were assessed (ELISA) in H. pylori ‐positive cases. At least 3 biopsy samples per patient were considered, and IM was scored as present versus absent. The prevalence of H. pylori , CagA+ve status, and IM was compared with the incidence of GC according to the regional cancer registries. Results: The prevalence of H. pylori was similar for the Europoids and Mongoloids (93.6 vs 94.3%). The prevalence of CagA+ve infection was as follows: Europoids 61.2%, Evenks 36.4%, Khakass 44.0%, Tuvans 60.0% ( p 1vs2 < .001; p 1vs3 < .001; p 2vs4 < .001; p 3vs4 < .001). The prevalence of IM was as follows: Europoids 10.7%, Evenks 5.1%, Khakass 9.8%, and Tuvans 23.4% ( p 1vs2 = .001; p 1vs4 < .001; p 2vs4 < .001; p 3vs4 < .001). The incidence of GC (per 100,000 population/year) was as follows: Europoids 33.2; Evenks 18.2; Khakass 20.2; Tuvans 50.7 ( p 1vs2 = 0.04; p 1vs3 = .05; p 2vs4 < .001; p 3vs4 < .001). Conclusion: H. pylori infection is consistently high in Russian and eastern Siberian populations; ethnicities with similar prevalence of CagA+ve status had different prevalence of IM and incidence of GC. As expected, IM prevalence correlated with the incidence of GC. Host‐related and/or environmental factors may explain discrepancies between H. pylori status, the prevalence of IM, and ... Article in Journal/Newspaper Evenks Siberia Wiley Online Library Helicobacter 16 2 107 112 |
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Abstract Background: The incidence of gastric cancer (GC) is extremely high in Russia and eastern Siberia, where information on the epidemiology of Helicobacter pylori infection is fragmentary. Aims: To assess the prevalence of both H. pylori infection (including CagA status) and intestinal metaplasia (IM) in Russian and eastern Siberian populations carrying a different risk of GC. Materials and Methods: A sample of 2129 consecutive patients was considered, including 689 Europoids and 1440 Mongoloids (493 Evenks, 533 Khakass people, and 414 Tuvans), who all underwent serum sampling and upper gastrointestinal endoscopy. H. pylori status was established (ELISA, urease test, and histology), and IgG anti‐CagA antibodies were assessed (ELISA) in H. pylori ‐positive cases. At least 3 biopsy samples per patient were considered, and IM was scored as present versus absent. The prevalence of H. pylori , CagA+ve status, and IM was compared with the incidence of GC according to the regional cancer registries. Results: The prevalence of H. pylori was similar for the Europoids and Mongoloids (93.6 vs 94.3%). The prevalence of CagA+ve infection was as follows: Europoids 61.2%, Evenks 36.4%, Khakass 44.0%, Tuvans 60.0% ( p 1vs2 < .001; p 1vs3 < .001; p 2vs4 < .001; p 3vs4 < .001). The prevalence of IM was as follows: Europoids 10.7%, Evenks 5.1%, Khakass 9.8%, and Tuvans 23.4% ( p 1vs2 = .001; p 1vs4 < .001; p 2vs4 < .001; p 3vs4 < .001). The incidence of GC (per 100,000 population/year) was as follows: Europoids 33.2; Evenks 18.2; Khakass 20.2; Tuvans 50.7 ( p 1vs2 = 0.04; p 1vs3 = .05; p 2vs4 < .001; p 3vs4 < .001). Conclusion: H. pylori infection is consistently high in Russian and eastern Siberian populations; ethnicities with similar prevalence of CagA+ve status had different prevalence of IM and incidence of GC. As expected, IM prevalence correlated with the incidence of GC. Host‐related and/or environmental factors may explain discrepancies between H. pylori status, the prevalence of IM, and ... |
format |
Article in Journal/Newspaper |
author |
Tsukanov, Vladislav Vladimirovich Butorin, Nikolai Nikolaevich Maady, Ayas Sergeevich Shtygasheva, Olga Vladimirovna Amelchugova, Olga Sergeevna Tonkikh, Julia Leongardovna Fassan, Matteo Rugge, Massimo |
spellingShingle |
Tsukanov, Vladislav Vladimirovich Butorin, Nikolai Nikolaevich Maady, Ayas Sergeevich Shtygasheva, Olga Vladimirovna Amelchugova, Olga Sergeevna Tonkikh, Julia Leongardovna Fassan, Matteo Rugge, Massimo Helicobacter pylori Infection, Intestinal Metaplasia, and Gastric Cancer Risk in Eastern Siberia |
author_facet |
Tsukanov, Vladislav Vladimirovich Butorin, Nikolai Nikolaevich Maady, Ayas Sergeevich Shtygasheva, Olga Vladimirovna Amelchugova, Olga Sergeevna Tonkikh, Julia Leongardovna Fassan, Matteo Rugge, Massimo |
author_sort |
Tsukanov, Vladislav Vladimirovich |
title |
Helicobacter pylori Infection, Intestinal Metaplasia, and Gastric Cancer Risk in Eastern Siberia |
title_short |
Helicobacter pylori Infection, Intestinal Metaplasia, and Gastric Cancer Risk in Eastern Siberia |
title_full |
Helicobacter pylori Infection, Intestinal Metaplasia, and Gastric Cancer Risk in Eastern Siberia |
title_fullStr |
Helicobacter pylori Infection, Intestinal Metaplasia, and Gastric Cancer Risk in Eastern Siberia |
title_full_unstemmed |
Helicobacter pylori Infection, Intestinal Metaplasia, and Gastric Cancer Risk in Eastern Siberia |
title_sort |
helicobacter pylori infection, intestinal metaplasia, and gastric cancer risk in eastern siberia |
publisher |
Wiley |
publishDate |
2011 |
url |
http://dx.doi.org/10.1111/j.1523-5378.2011.00827.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1523-5378.2011.00827.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1523-5378.2011.00827.x |
genre |
Evenks Siberia |
genre_facet |
Evenks Siberia |
op_source |
Helicobacter volume 16, issue 2, page 107-112 ISSN 1083-4389 1523-5378 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1523-5378.2011.00827.x |
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Helicobacter |
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16 |
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2 |
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107 |
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112 |
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1802643941094326272 |