Inhibition of NMDA‐type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii)
J. Neurochem . (2012) 122 , 934–940. Abstract Hibernation is an adaptation to overcome periods of resource limitation often associated with extreme climatic conditions. The hibernation season consists of prolonged bouts of torpor that are interrupted by brief interbout arousals. Physiological mechan...
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crwiley:10.1111/j.1471-4159.2012.07832.x 2024-06-02T08:00:12+00:00 Inhibition of NMDA‐type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii) Jinka, Tulasi R. Rasley, Brian T. Drew, Kelly L. 2012 http://dx.doi.org/10.1111/j.1471-4159.2012.07832.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-4159.2012.07832.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.2012.07832.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Neurochemistry volume 122, issue 5, page 934-940 ISSN 0022-3042 1471-4159 journal-article 2012 crwiley https://doi.org/10.1111/j.1471-4159.2012.07832.x 2024-05-03T10:36:18Z J. Neurochem . (2012) 122 , 934–940. Abstract Hibernation is an adaptation to overcome periods of resource limitation often associated with extreme climatic conditions. The hibernation season consists of prolonged bouts of torpor that are interrupted by brief interbout arousals. Physiological mechanisms regulating spontaneous arousals are poorly understood, but may be related to a need for gluconeogenesis or elimination of metabolic wastes. Glutamate is derived from glutamine through the glutamate–glutamine cycle and from glucose via the pyruvate carboxylase pathway when nitrogen balance favors formation of glutamine. This study tests the hypothesis that activation of NMDA‐type glutamate receptors (NMDAR) maintains torpor in arctic ground squirrel (arctic ground squirrel (AGS); Urocitellus parryii). Administration of NMDAR antagonists MK‐801 (5 mg/kg, i.p.) that crosses the blood–brain barrier and AP5 (5 mg/kg, i.p.) that does not cross the blood–brain barrier induced arousal in AGS. Central administration of MK‐801 (0.2, 2, 20 or 200 μg; icv) to hibernating AGS failed to induce arousal. Results suggest that activation of NMDAR at a peripheral or circumventricular site is necessary to maintain prolonged torpor and that a decrease in glutamate at these sites may contribute to spontaneous arousal in AGS. Article in Journal/Newspaper Arctic ground squirrel Arctic Urocitellus parryii Wiley Online Library Arctic Journal of Neurochemistry 122 5 934 940 |
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English |
description |
J. Neurochem . (2012) 122 , 934–940. Abstract Hibernation is an adaptation to overcome periods of resource limitation often associated with extreme climatic conditions. The hibernation season consists of prolonged bouts of torpor that are interrupted by brief interbout arousals. Physiological mechanisms regulating spontaneous arousals are poorly understood, but may be related to a need for gluconeogenesis or elimination of metabolic wastes. Glutamate is derived from glutamine through the glutamate–glutamine cycle and from glucose via the pyruvate carboxylase pathway when nitrogen balance favors formation of glutamine. This study tests the hypothesis that activation of NMDA‐type glutamate receptors (NMDAR) maintains torpor in arctic ground squirrel (arctic ground squirrel (AGS); Urocitellus parryii). Administration of NMDAR antagonists MK‐801 (5 mg/kg, i.p.) that crosses the blood–brain barrier and AP5 (5 mg/kg, i.p.) that does not cross the blood–brain barrier induced arousal in AGS. Central administration of MK‐801 (0.2, 2, 20 or 200 μg; icv) to hibernating AGS failed to induce arousal. Results suggest that activation of NMDAR at a peripheral or circumventricular site is necessary to maintain prolonged torpor and that a decrease in glutamate at these sites may contribute to spontaneous arousal in AGS. |
format |
Article in Journal/Newspaper |
author |
Jinka, Tulasi R. Rasley, Brian T. Drew, Kelly L. |
spellingShingle |
Jinka, Tulasi R. Rasley, Brian T. Drew, Kelly L. Inhibition of NMDA‐type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii) |
author_facet |
Jinka, Tulasi R. Rasley, Brian T. Drew, Kelly L. |
author_sort |
Jinka, Tulasi R. |
title |
Inhibition of NMDA‐type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii) |
title_short |
Inhibition of NMDA‐type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii) |
title_full |
Inhibition of NMDA‐type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii) |
title_fullStr |
Inhibition of NMDA‐type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii) |
title_full_unstemmed |
Inhibition of NMDA‐type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii) |
title_sort |
inhibition of nmda‐type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (urocitellus parryii) |
publisher |
Wiley |
publishDate |
2012 |
url |
http://dx.doi.org/10.1111/j.1471-4159.2012.07832.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-4159.2012.07832.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.2012.07832.x |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic ground squirrel Arctic Urocitellus parryii |
genre_facet |
Arctic ground squirrel Arctic Urocitellus parryii |
op_source |
Journal of Neurochemistry volume 122, issue 5, page 934-940 ISSN 0022-3042 1471-4159 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1471-4159.2012.07832.x |
container_title |
Journal of Neurochemistry |
container_volume |
122 |
container_issue |
5 |
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934 |
op_container_end_page |
940 |
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1800744196063100928 |