Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid

Abstract Oxidative stress is implicated in the cognitive deterioration associated with normal aging as well as neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. We investigated the effect of ascorbic acid (vitamin C) on oxidative stress, cognition, and motor abilities in mice...

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Published in:Journal of Neurochemistry
Main Authors: Harrison, Fiona E., Yu, Sarah S., Van Den Bossche, Kristen L., Li, Liying, May, James M., McDonald, Michael P.
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2008
Subjects:
Online Access:http://dx.doi.org/10.1111/j.1471-4159.2008.05469.x
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spelling crwiley:10.1111/j.1471-4159.2008.05469.x 2024-10-06T13:49:16+00:00 Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid Harrison, Fiona E. Yu, Sarah S. Van Den Bossche, Kristen L. Li, Liying May, James M. McDonald, Michael P. 2008 http://dx.doi.org/10.1111/j.1471-4159.2008.05469.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-4159.2008.05469.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.2008.05469.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Neurochemistry volume 106, issue 3, page 1198-1208 ISSN 0022-3042 1471-4159 journal-article 2008 crwiley https://doi.org/10.1111/j.1471-4159.2008.05469.x 2024-09-11T04:12:03Z Abstract Oxidative stress is implicated in the cognitive deterioration associated with normal aging as well as neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. We investigated the effect of ascorbic acid (vitamin C) on oxidative stress, cognition, and motor abilities in mice null for gulono‐γ‐lactone oxidase (Gulo). Gulo−/− mice are unable to synthesize ascorbic acid and depend on dietary ascorbic acid for survival. Gulo−/− mice were given supplements that provided them either with ascorbic acid levels equal to‐ or slightly higher than wild‐type mice (Gulo‐sufficient), or lower than physiological levels (Gulo‐low) that were just enough to prevent scurvy. Ascorbic acid is a major anti‐oxidant in mice and any reduction in ascorbic acid level is therefore likely to result in increased oxidative stress. Ascorbic acid levels in the brain and liver were higher in Gulo‐sufficient mice than in Gulo‐low mice. F 4 ‐neuroprostanes were elevated in cortex and cerebellum in Gulo‐low mice and in the cortex of Gulo‐sufficient mice. All Gulo−/− mice were cognitively normal but had a strength and agility deficit that was worse in Gulo‐low mice. This suggests that low levels of ascorbic acid and elevated oxidative stress as measured by F 4 ‐neuroprostanes alone are insufficient to impair memory in the knockouts but may be responsible for the exacerbated motor deficits in Gulo‐low mice, and ascorbic acid may have a vital role in maintaining motor abilities. Article in Journal/Newspaper Gulo gulo Wiley Online Library Journal of Neurochemistry 106 3 1198 1208
institution Open Polar
collection Wiley Online Library
op_collection_id crwiley
language English
description Abstract Oxidative stress is implicated in the cognitive deterioration associated with normal aging as well as neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. We investigated the effect of ascorbic acid (vitamin C) on oxidative stress, cognition, and motor abilities in mice null for gulono‐γ‐lactone oxidase (Gulo). Gulo−/− mice are unable to synthesize ascorbic acid and depend on dietary ascorbic acid for survival. Gulo−/− mice were given supplements that provided them either with ascorbic acid levels equal to‐ or slightly higher than wild‐type mice (Gulo‐sufficient), or lower than physiological levels (Gulo‐low) that were just enough to prevent scurvy. Ascorbic acid is a major anti‐oxidant in mice and any reduction in ascorbic acid level is therefore likely to result in increased oxidative stress. Ascorbic acid levels in the brain and liver were higher in Gulo‐sufficient mice than in Gulo‐low mice. F 4 ‐neuroprostanes were elevated in cortex and cerebellum in Gulo‐low mice and in the cortex of Gulo‐sufficient mice. All Gulo−/− mice were cognitively normal but had a strength and agility deficit that was worse in Gulo‐low mice. This suggests that low levels of ascorbic acid and elevated oxidative stress as measured by F 4 ‐neuroprostanes alone are insufficient to impair memory in the knockouts but may be responsible for the exacerbated motor deficits in Gulo‐low mice, and ascorbic acid may have a vital role in maintaining motor abilities.
format Article in Journal/Newspaper
author Harrison, Fiona E.
Yu, Sarah S.
Van Den Bossche, Kristen L.
Li, Liying
May, James M.
McDonald, Michael P.
spellingShingle Harrison, Fiona E.
Yu, Sarah S.
Van Den Bossche, Kristen L.
Li, Liying
May, James M.
McDonald, Michael P.
Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
author_facet Harrison, Fiona E.
Yu, Sarah S.
Van Den Bossche, Kristen L.
Li, Liying
May, James M.
McDonald, Michael P.
author_sort Harrison, Fiona E.
title Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
title_short Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
title_full Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
title_fullStr Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
title_full_unstemmed Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
title_sort elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
publisher Wiley
publishDate 2008
url http://dx.doi.org/10.1111/j.1471-4159.2008.05469.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-4159.2008.05469.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.2008.05469.x
genre Gulo gulo
genre_facet Gulo gulo
op_source Journal of Neurochemistry
volume 106, issue 3, page 1198-1208
ISSN 0022-3042 1471-4159
op_rights http://onlinelibrary.wiley.com/termsAndConditions#vor
op_doi https://doi.org/10.1111/j.1471-4159.2008.05469.x
container_title Journal of Neurochemistry
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