Dyslipoproteinaemia in postmenopausal women with a history of eclampsia

Objective To test the hypothesis that postmenopausal women with a history of eclampsia manifest a more high risk lipid profile than postmenopausal women with a history of normal pregnancy. Setting The Department of Obstetrics and Gynaecology, National University Hospital, Reykjavik, Iceland, and the...

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Published in:BJOG: An International Journal of Obstetrics & Gynaecology
Main Authors: Hubel, Carl A., Snaedal, Sunna, Ness, Roberta B., Weissfeld, Lisa A., Geirsson, Reynir T., Roberts, James M., Arngrímsson, Reynir
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2000
Subjects:
Online Access:http://dx.doi.org/10.1111/j.1471-0528.2000.tb13340.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-0528.2000.tb13340.x
https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-0528.2000.tb13340.x
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spelling crwiley:10.1111/j.1471-0528.2000.tb13340.x 2024-06-09T07:47:12+00:00 Dyslipoproteinaemia in postmenopausal women with a history of eclampsia Hubel, Carl A. Snaedal, Sunna Ness, Roberta B. Weissfeld, Lisa A. Geirsson, Reynir T. Roberts, James M. Arngrímsson, Reynir 2000 http://dx.doi.org/10.1111/j.1471-0528.2000.tb13340.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-0528.2000.tb13340.x https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-0528.2000.tb13340.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor BJOG: An International Journal of Obstetrics & Gynaecology volume 107, issue 6, page 776-784 ISSN 1470-0328 1471-0528 journal-article 2000 crwiley https://doi.org/10.1111/j.1471-0528.2000.tb13340.x 2024-05-16T14:27:03Z Objective To test the hypothesis that postmenopausal women with a history of eclampsia manifest a more high risk lipid profile than postmenopausal women with a history of normal pregnancy. Setting The Department of Obstetrics and Gynaecology, National University Hospital, Reykjavik, Iceland, and the Magee‐Womens Research Institute, Pittsburgh, Pennsylvania, USA. Participants Thirty Icelandic women with a history of eclampsia, aged between 50 and 67 years at the time of re‐examination (cases) were individually matched for current age, and for age and parity at index pregnancy, to 30 unrelated Icelandic women with a history of normal pregnancy (controls). Methods The participating women completed a health and family history questionnaire and underwent a physical examination. Fasting plasma low density lipoprotein diameter, serum lipids, insulin, and glucose were measured. Results Mean low density lipoprotein size was significantly smaller and apolipoprotein B concentration was higher in women with prior eclampsia. The percentage of cases receiving blood pressure medication (33%) was significantly greater than controls (6.7%). Thirteen cases had had hypertensive complications in at least one other pregnancy (recurrent subgroup); postmenopausally, these women displayed significantly increased diastolic blood pressures, smaller‐sized low density lipoprotein, increased apolipoprotein B, decreased high density lipoprotein 2 (HDL 2 ) cholesterol, and increased total cholesterol: HDL cholesterol ratio compared with their controls. Fourteen cases were normotensive in all other pregnancies (nonrecurrent); these showed no differences from their controls. Conclusions Dyslipoproteinaemia is more prevalent among postmenopausal women with prior eclampsia, especially with recurrent hypertension in pregnancy, than in postmenopausal women with prior normal pregnancies. Article in Journal/Newspaper Iceland Wiley Online Library BJOG: An International Journal of Obstetrics & Gynaecology 107 6 776 784
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collection Wiley Online Library
op_collection_id crwiley
language English
description Objective To test the hypothesis that postmenopausal women with a history of eclampsia manifest a more high risk lipid profile than postmenopausal women with a history of normal pregnancy. Setting The Department of Obstetrics and Gynaecology, National University Hospital, Reykjavik, Iceland, and the Magee‐Womens Research Institute, Pittsburgh, Pennsylvania, USA. Participants Thirty Icelandic women with a history of eclampsia, aged between 50 and 67 years at the time of re‐examination (cases) were individually matched for current age, and for age and parity at index pregnancy, to 30 unrelated Icelandic women with a history of normal pregnancy (controls). Methods The participating women completed a health and family history questionnaire and underwent a physical examination. Fasting plasma low density lipoprotein diameter, serum lipids, insulin, and glucose were measured. Results Mean low density lipoprotein size was significantly smaller and apolipoprotein B concentration was higher in women with prior eclampsia. The percentage of cases receiving blood pressure medication (33%) was significantly greater than controls (6.7%). Thirteen cases had had hypertensive complications in at least one other pregnancy (recurrent subgroup); postmenopausally, these women displayed significantly increased diastolic blood pressures, smaller‐sized low density lipoprotein, increased apolipoprotein B, decreased high density lipoprotein 2 (HDL 2 ) cholesterol, and increased total cholesterol: HDL cholesterol ratio compared with their controls. Fourteen cases were normotensive in all other pregnancies (nonrecurrent); these showed no differences from their controls. Conclusions Dyslipoproteinaemia is more prevalent among postmenopausal women with prior eclampsia, especially with recurrent hypertension in pregnancy, than in postmenopausal women with prior normal pregnancies.
format Article in Journal/Newspaper
author Hubel, Carl A.
Snaedal, Sunna
Ness, Roberta B.
Weissfeld, Lisa A.
Geirsson, Reynir T.
Roberts, James M.
Arngrímsson, Reynir
spellingShingle Hubel, Carl A.
Snaedal, Sunna
Ness, Roberta B.
Weissfeld, Lisa A.
Geirsson, Reynir T.
Roberts, James M.
Arngrímsson, Reynir
Dyslipoproteinaemia in postmenopausal women with a history of eclampsia
author_facet Hubel, Carl A.
Snaedal, Sunna
Ness, Roberta B.
Weissfeld, Lisa A.
Geirsson, Reynir T.
Roberts, James M.
Arngrímsson, Reynir
author_sort Hubel, Carl A.
title Dyslipoproteinaemia in postmenopausal women with a history of eclampsia
title_short Dyslipoproteinaemia in postmenopausal women with a history of eclampsia
title_full Dyslipoproteinaemia in postmenopausal women with a history of eclampsia
title_fullStr Dyslipoproteinaemia in postmenopausal women with a history of eclampsia
title_full_unstemmed Dyslipoproteinaemia in postmenopausal women with a history of eclampsia
title_sort dyslipoproteinaemia in postmenopausal women with a history of eclampsia
publisher Wiley
publishDate 2000
url http://dx.doi.org/10.1111/j.1471-0528.2000.tb13340.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-0528.2000.tb13340.x
https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-0528.2000.tb13340.x
genre Iceland
genre_facet Iceland
op_source BJOG: An International Journal of Obstetrics & Gynaecology
volume 107, issue 6, page 776-784
ISSN 1470-0328 1471-0528
op_rights http://onlinelibrary.wiley.com/termsAndConditions#vor
op_doi https://doi.org/10.1111/j.1471-0528.2000.tb13340.x
container_title BJOG: An International Journal of Obstetrics & Gynaecology
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