Increased plasma levels of vasoactive intestinal polypeptide in pre‐eclampsia
Abstract Objective— To investigate the plasma vasoactive peptide (VIP) levels in pregnancies complicated by pre‐eclampsia. Design— A prospective clinical study. Setting— University Department of Obstetrics, Tromso, Norway. Subjects— 18 women with untreated gestational proteinuric hypertension betwee...
Published in: | BJOG: An International Journal of Obstetrics & Gynaecology |
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Language: | English |
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Online Access: | http://dx.doi.org/10.1111/j.1471-0528.1991.tb13486.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-0528.1991.tb13486.x https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-0528.1991.tb13486.x |
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crwiley:10.1111/j.1471-0528.1991.tb13486.x 2024-06-02T08:15:17+00:00 Increased plasma levels of vasoactive intestinal polypeptide in pre‐eclampsia HOLST, N. ØIAN, P. AUNE, B. JENSSEN, T. G. BURHOL, P. G. 1991 http://dx.doi.org/10.1111/j.1471-0528.1991.tb13486.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-0528.1991.tb13486.x https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-0528.1991.tb13486.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor BJOG: An International Journal of Obstetrics & Gynaecology volume 98, issue 8, page 803-806 ISSN 1470-0328 1471-0528 journal-article 1991 crwiley https://doi.org/10.1111/j.1471-0528.1991.tb13486.x 2024-05-03T12:03:09Z Abstract Objective— To investigate the plasma vasoactive peptide (VIP) levels in pregnancies complicated by pre‐eclampsia. Design— A prospective clinical study. Setting— University Department of Obstetrics, Tromso, Norway. Subjects— 18 women with untreated gestational proteinuric hypertension between 32 and 40 weeks gestation (13 primigravid) and 8 women with normal pregnancies of similar gestational age. Interventions— Fasting blood samples on two occasions, 10 min apart. Main outcome measures— Plasma VIP measured by radioimmunoassay. Results— Mean maternal plasma VIP was 13–9 (SEM 1–7) pmol/l in those with pre‐eclampsia and 4–4 (SEM 0–5) pmol/l in normal pregnancies ( P<0.0001 ). Conclusion— The increased levels of VIP in pre‐eclampsia may represent a powerful compensatory mechanism to restore vascular perfusion of various organs, including the uterus and placenta. Article in Journal/Newspaper Tromso Tromso Wiley Online Library Norway Tromso ENVELOPE(16.546,16.546,68.801,68.801) BJOG: An International Journal of Obstetrics & Gynaecology 98 8 803 806 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract Objective— To investigate the plasma vasoactive peptide (VIP) levels in pregnancies complicated by pre‐eclampsia. Design— A prospective clinical study. Setting— University Department of Obstetrics, Tromso, Norway. Subjects— 18 women with untreated gestational proteinuric hypertension between 32 and 40 weeks gestation (13 primigravid) and 8 women with normal pregnancies of similar gestational age. Interventions— Fasting blood samples on two occasions, 10 min apart. Main outcome measures— Plasma VIP measured by radioimmunoassay. Results— Mean maternal plasma VIP was 13–9 (SEM 1–7) pmol/l in those with pre‐eclampsia and 4–4 (SEM 0–5) pmol/l in normal pregnancies ( P<0.0001 ). Conclusion— The increased levels of VIP in pre‐eclampsia may represent a powerful compensatory mechanism to restore vascular perfusion of various organs, including the uterus and placenta. |
format |
Article in Journal/Newspaper |
author |
HOLST, N. ØIAN, P. AUNE, B. JENSSEN, T. G. BURHOL, P. G. |
spellingShingle |
HOLST, N. ØIAN, P. AUNE, B. JENSSEN, T. G. BURHOL, P. G. Increased plasma levels of vasoactive intestinal polypeptide in pre‐eclampsia |
author_facet |
HOLST, N. ØIAN, P. AUNE, B. JENSSEN, T. G. BURHOL, P. G. |
author_sort |
HOLST, N. |
title |
Increased plasma levels of vasoactive intestinal polypeptide in pre‐eclampsia |
title_short |
Increased plasma levels of vasoactive intestinal polypeptide in pre‐eclampsia |
title_full |
Increased plasma levels of vasoactive intestinal polypeptide in pre‐eclampsia |
title_fullStr |
Increased plasma levels of vasoactive intestinal polypeptide in pre‐eclampsia |
title_full_unstemmed |
Increased plasma levels of vasoactive intestinal polypeptide in pre‐eclampsia |
title_sort |
increased plasma levels of vasoactive intestinal polypeptide in pre‐eclampsia |
publisher |
Wiley |
publishDate |
1991 |
url |
http://dx.doi.org/10.1111/j.1471-0528.1991.tb13486.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-0528.1991.tb13486.x https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-0528.1991.tb13486.x |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Norway Tromso |
geographic_facet |
Norway Tromso |
genre |
Tromso Tromso |
genre_facet |
Tromso Tromso |
op_source |
BJOG: An International Journal of Obstetrics & Gynaecology volume 98, issue 8, page 803-806 ISSN 1470-0328 1471-0528 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1471-0528.1991.tb13486.x |
container_title |
BJOG: An International Journal of Obstetrics & Gynaecology |
container_volume |
98 |
container_issue |
8 |
container_start_page |
803 |
op_container_end_page |
806 |
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1800739412799127552 |