A population study of alpha‐keto acid reductase

• Published in: Annals of Human Genetics
• Main Authors: FRIEDRICH, C. A., FERRELL, R. E.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 1985
• Subjects: eskimo*
• Online Access: http://dx.doi.org/10.1111/j.1469-1809.1985.tb01682.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1469-1809.1985.tb01682.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1469-1809.1985.tb01682.x

Summary An electrophoretic survey of 509 individuals of Japanese, Mexican American, American Negro, Eskimo, Amerindian and Anglo‐American origin failed to reveal genetically determined variation at the alpha‐keto acid reductase locus by starch gel electrophoresis. Additional screening of 232 individuals by thin layer isoelectric focusing in polyacrylamide gels detected a single phenotype. Interspecific variation at the alpha‐keto acid reductase locus is clearly resolved using either method. These results indicate that the alpha‐keto acid reductase locus is monomorphic in most human population groups despite earlier results suggesting the existence of genetic polymorphism.