Baseline serum 25‐hydroxyvitamin D concentrations in the Tromsø Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow‐up

Diabet. Med. 27, 1107–1115 (2010) Abstract Aims We wanted to test the hypothesis that low serum 25‐hydroxyvitamin D (25(OH)D) concentrations are associated with increased risk of developing Type 2 diabetes mellitus (DM) in a population‐based cohort during 11 years of follow‐up. Methods The analyses...

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Published in:Diabetic Medicine
Main Authors: Grimnes, G., Emaus, N., Joakimsen, R. M., Figenschau, Y., Jenssen, T., Njølstad, I., Schirmer, H., Jorde, R.
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2010
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Online Access:http://dx.doi.org/10.1111/j.1464-5491.2010.03092.x
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spelling crwiley:10.1111/j.1464-5491.2010.03092.x 2024-09-30T14:45:09+00:00 Baseline serum 25‐hydroxyvitamin D concentrations in the Tromsø Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow‐up Grimnes, G. Emaus, N. Joakimsen, R. M. Figenschau, Y. Jenssen, T. Njølstad, I. Schirmer, H. Jorde, R. 2010 http://dx.doi.org/10.1111/j.1464-5491.2010.03092.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1464-5491.2010.03092.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1464-5491.2010.03092.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Diabetic Medicine volume 27, issue 10, page 1107-1115 ISSN 0742-3071 1464-5491 journal-article 2010 crwiley https://doi.org/10.1111/j.1464-5491.2010.03092.x 2024-09-05T05:08:13Z Diabet. Med. 27, 1107–1115 (2010) Abstract Aims We wanted to test the hypothesis that low serum 25‐hydroxyvitamin D (25(OH)D) concentrations are associated with increased risk of developing Type 2 diabetes mellitus (DM) in a population‐based cohort during 11 years of follow‐up. Methods The analyses included 4157 non‐smokers and 1962 smokers from the Tromsø Study 1994–95 without diabetes at baseline. Subsequent Type 2 DM was defined using a hospital journal‐based end‐point registry, completed through the year 2005. Participants were allocated into quartiles of serum 25(OH)D within each month to account for seasonal variation, and serum 25(OH)D values both as a continuous variable and in quartiles were used in Cox regression models. The analyses were stratified by smoking. Adjustments were made for age, sex, body mass index (BMI), physical activity and, in non‐smokers, former smoking. Results Type 2 DM was registered in 183 non‐smoking and 64 smoking participants. Using the fourth (highest) quartile of serum 25(OH)D as the reference, non‐smoking participants in the third, second and first quartiles had age‐ and sex‐adjusted hazard ratios (95% confidence intervals) of incident Type 2 DM of 1.00 (0.62–1.61), 1.50 (0.97–2.31) and 1.89 (1.25–2.88), respectively, whereas the corresponding values for smokers were 1.79 (0.77–4.19), 2.33 (1.02–5.35) and 2.68 (1.18–6.08). Adjustment for BMI attenuated the hazard ratios, and they were no longer significant. Conclusions Baseline serum 25(OH)D was inversely associated with subsequent Type 2 DM in a population‐based 11 year follow‐up study, but not after adjustment for BMI. Randomized trials are needed to define the possible role of serum 25(OH)D status, and thereby the role of supplementation, in the prevention of Type 2 DM. Article in Journal/Newspaper Tromsø Wiley Online Library Tromsø Diabetic Medicine 27 10 1107 1115
institution Open Polar
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language English
description Diabet. Med. 27, 1107–1115 (2010) Abstract Aims We wanted to test the hypothesis that low serum 25‐hydroxyvitamin D (25(OH)D) concentrations are associated with increased risk of developing Type 2 diabetes mellitus (DM) in a population‐based cohort during 11 years of follow‐up. Methods The analyses included 4157 non‐smokers and 1962 smokers from the Tromsø Study 1994–95 without diabetes at baseline. Subsequent Type 2 DM was defined using a hospital journal‐based end‐point registry, completed through the year 2005. Participants were allocated into quartiles of serum 25(OH)D within each month to account for seasonal variation, and serum 25(OH)D values both as a continuous variable and in quartiles were used in Cox regression models. The analyses were stratified by smoking. Adjustments were made for age, sex, body mass index (BMI), physical activity and, in non‐smokers, former smoking. Results Type 2 DM was registered in 183 non‐smoking and 64 smoking participants. Using the fourth (highest) quartile of serum 25(OH)D as the reference, non‐smoking participants in the third, second and first quartiles had age‐ and sex‐adjusted hazard ratios (95% confidence intervals) of incident Type 2 DM of 1.00 (0.62–1.61), 1.50 (0.97–2.31) and 1.89 (1.25–2.88), respectively, whereas the corresponding values for smokers were 1.79 (0.77–4.19), 2.33 (1.02–5.35) and 2.68 (1.18–6.08). Adjustment for BMI attenuated the hazard ratios, and they were no longer significant. Conclusions Baseline serum 25(OH)D was inversely associated with subsequent Type 2 DM in a population‐based 11 year follow‐up study, but not after adjustment for BMI. Randomized trials are needed to define the possible role of serum 25(OH)D status, and thereby the role of supplementation, in the prevention of Type 2 DM.
format Article in Journal/Newspaper
author Grimnes, G.
Emaus, N.
Joakimsen, R. M.
Figenschau, Y.
Jenssen, T.
Njølstad, I.
Schirmer, H.
Jorde, R.
spellingShingle Grimnes, G.
Emaus, N.
Joakimsen, R. M.
Figenschau, Y.
Jenssen, T.
Njølstad, I.
Schirmer, H.
Jorde, R.
Baseline serum 25‐hydroxyvitamin D concentrations in the Tromsø Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow‐up
author_facet Grimnes, G.
Emaus, N.
Joakimsen, R. M.
Figenschau, Y.
Jenssen, T.
Njølstad, I.
Schirmer, H.
Jorde, R.
author_sort Grimnes, G.
title Baseline serum 25‐hydroxyvitamin D concentrations in the Tromsø Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow‐up
title_short Baseline serum 25‐hydroxyvitamin D concentrations in the Tromsø Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow‐up
title_full Baseline serum 25‐hydroxyvitamin D concentrations in the Tromsø Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow‐up
title_fullStr Baseline serum 25‐hydroxyvitamin D concentrations in the Tromsø Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow‐up
title_full_unstemmed Baseline serum 25‐hydroxyvitamin D concentrations in the Tromsø Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow‐up
title_sort baseline serum 25‐hydroxyvitamin d concentrations in the tromsø study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow‐up
publisher Wiley
publishDate 2010
url http://dx.doi.org/10.1111/j.1464-5491.2010.03092.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1464-5491.2010.03092.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1464-5491.2010.03092.x
geographic Tromsø
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op_source Diabetic Medicine
volume 27, issue 10, page 1107-1115
ISSN 0742-3071 1464-5491
op_rights http://onlinelibrary.wiley.com/termsAndConditions#vor
op_doi https://doi.org/10.1111/j.1464-5491.2010.03092.x
container_title Diabetic Medicine
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container_issue 10
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