Fenton chemistry and oxidative stress mediate the toxicity of the β‐amyloid peptide in a Drosophila model of Alzheimer’s disease

• Published in: European Journal of Neuroscience
• Main Authors: Rival, Thomas, Page, Richard M., Chandraratna, Dhianjali S., Sendall, Timothy J., Ryder, Edward, Liu, Beinan, Lewis, Huw, Rosahl, Thomas, Hider, Robert, Camargo, L. M., Shearman, Mark S., Crowther, Damian C., Lomas, David A.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2009
• Subjects: Arctic; Fenton
• Online Access: http://dx.doi.org/10.1111/j.1460-9568.2009.06701.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1460-9568.2009.06701.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1460-9568.2009.06701.x

Abstract The mechanism by which aggregates of the β‐amyloid peptide (Aβ) mediate their toxicity is uncertain. We show here that the expression of the 42‐amino‐acid isoform of Aβ (Aβ 1–42 ) changes the expression of genes involved in oxidative stress in a Drosophila model of Alzheimer’s disease. A su...