MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success

Contents Major histocompatibility complex (MHC) class II genes are important genetic risk factors for development of immune‐mediated diseases in mammals. Recently, the dog ( Canis lupus familiaris ) has emerged as a useful model organism to identify critical MHC class II genotypes that contribute to...

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Published in:Reproduction in Domestic Animals
Main Authors: Wilbe, M, Andersson, G
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2011
Subjects:
Online Access:http://dx.doi.org/10.1111/j.1439-0531.2011.01962.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1439-0531.2011.01962.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1439-0531.2011.01962.x
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spelling crwiley:10.1111/j.1439-0531.2011.01962.x 2024-06-02T08:05:01+00:00 MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success Wilbe, M Andersson, G 2011 http://dx.doi.org/10.1111/j.1439-0531.2011.01962.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1439-0531.2011.01962.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1439-0531.2011.01962.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Reproduction in Domestic Animals volume 47, issue s1, page 27-30 ISSN 0936-6768 1439-0531 journal-article 2011 crwiley https://doi.org/10.1111/j.1439-0531.2011.01962.x 2024-05-03T10:57:35Z Contents Major histocompatibility complex (MHC) class II genes are important genetic risk factors for development of immune‐mediated diseases in mammals. Recently, the dog ( Canis lupus familiaris ) has emerged as a useful model organism to identify critical MHC class II genotypes that contribute to development of these diseases. Therefore, a study aimed to evaluate a potential genetic association between the dog leukocyte antigen (DLA) class II region and an immune‐mediated disease complex in dogs of the Nova Scotia duck tolling retriever breed was performed. We show that DLA is one of several genetic risk factors for this disease complex and that homozygosity of the risk haplotype is disadvantageous. Importantly, the disease is complex and has many genetic risk factors and therefore we cannot provide recommendations for breeders exclusively on the basis of genetic testing for DLA class II genotype. Article in Journal/Newspaper Canis lupus Wiley Online Library Reproduction in Domestic Animals 47 s1 27 30
institution Open Polar
collection Wiley Online Library
op_collection_id crwiley
language English
description Contents Major histocompatibility complex (MHC) class II genes are important genetic risk factors for development of immune‐mediated diseases in mammals. Recently, the dog ( Canis lupus familiaris ) has emerged as a useful model organism to identify critical MHC class II genotypes that contribute to development of these diseases. Therefore, a study aimed to evaluate a potential genetic association between the dog leukocyte antigen (DLA) class II region and an immune‐mediated disease complex in dogs of the Nova Scotia duck tolling retriever breed was performed. We show that DLA is one of several genetic risk factors for this disease complex and that homozygosity of the risk haplotype is disadvantageous. Importantly, the disease is complex and has many genetic risk factors and therefore we cannot provide recommendations for breeders exclusively on the basis of genetic testing for DLA class II genotype.
format Article in Journal/Newspaper
author Wilbe, M
Andersson, G
spellingShingle Wilbe, M
Andersson, G
MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success
author_facet Wilbe, M
Andersson, G
author_sort Wilbe, M
title MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success
title_short MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success
title_full MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success
title_fullStr MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success
title_full_unstemmed MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success
title_sort mhc class ii is an important genetic risk factor for canine systemic lupus erythematosus (sle)‐related disease: implications for reproductive success
publisher Wiley
publishDate 2011
url http://dx.doi.org/10.1111/j.1439-0531.2011.01962.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1439-0531.2011.01962.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1439-0531.2011.01962.x
genre Canis lupus
genre_facet Canis lupus
op_source Reproduction in Domestic Animals
volume 47, issue s1, page 27-30
ISSN 0936-6768 1439-0531
op_rights http://onlinelibrary.wiley.com/termsAndConditions#vor
op_doi https://doi.org/10.1111/j.1439-0531.2011.01962.x
container_title Reproduction in Domestic Animals
container_volume 47
container_issue s1
container_start_page 27
op_container_end_page 30
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