MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success
Contents Major histocompatibility complex (MHC) class II genes are important genetic risk factors for development of immune‐mediated diseases in mammals. Recently, the dog ( Canis lupus familiaris ) has emerged as a useful model organism to identify critical MHC class II genotypes that contribute to...
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crwiley:10.1111/j.1439-0531.2011.01962.x 2024-06-02T08:05:01+00:00 MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success Wilbe, M Andersson, G 2011 http://dx.doi.org/10.1111/j.1439-0531.2011.01962.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1439-0531.2011.01962.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1439-0531.2011.01962.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Reproduction in Domestic Animals volume 47, issue s1, page 27-30 ISSN 0936-6768 1439-0531 journal-article 2011 crwiley https://doi.org/10.1111/j.1439-0531.2011.01962.x 2024-05-03T10:57:35Z Contents Major histocompatibility complex (MHC) class II genes are important genetic risk factors for development of immune‐mediated diseases in mammals. Recently, the dog ( Canis lupus familiaris ) has emerged as a useful model organism to identify critical MHC class II genotypes that contribute to development of these diseases. Therefore, a study aimed to evaluate a potential genetic association between the dog leukocyte antigen (DLA) class II region and an immune‐mediated disease complex in dogs of the Nova Scotia duck tolling retriever breed was performed. We show that DLA is one of several genetic risk factors for this disease complex and that homozygosity of the risk haplotype is disadvantageous. Importantly, the disease is complex and has many genetic risk factors and therefore we cannot provide recommendations for breeders exclusively on the basis of genetic testing for DLA class II genotype. Article in Journal/Newspaper Canis lupus Wiley Online Library Reproduction in Domestic Animals 47 s1 27 30 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Contents Major histocompatibility complex (MHC) class II genes are important genetic risk factors for development of immune‐mediated diseases in mammals. Recently, the dog ( Canis lupus familiaris ) has emerged as a useful model organism to identify critical MHC class II genotypes that contribute to development of these diseases. Therefore, a study aimed to evaluate a potential genetic association between the dog leukocyte antigen (DLA) class II region and an immune‐mediated disease complex in dogs of the Nova Scotia duck tolling retriever breed was performed. We show that DLA is one of several genetic risk factors for this disease complex and that homozygosity of the risk haplotype is disadvantageous. Importantly, the disease is complex and has many genetic risk factors and therefore we cannot provide recommendations for breeders exclusively on the basis of genetic testing for DLA class II genotype. |
format |
Article in Journal/Newspaper |
author |
Wilbe, M Andersson, G |
spellingShingle |
Wilbe, M Andersson, G MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success |
author_facet |
Wilbe, M Andersson, G |
author_sort |
Wilbe, M |
title |
MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success |
title_short |
MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success |
title_full |
MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success |
title_fullStr |
MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success |
title_full_unstemmed |
MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success |
title_sort |
mhc class ii is an important genetic risk factor for canine systemic lupus erythematosus (sle)‐related disease: implications for reproductive success |
publisher |
Wiley |
publishDate |
2011 |
url |
http://dx.doi.org/10.1111/j.1439-0531.2011.01962.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1439-0531.2011.01962.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1439-0531.2011.01962.x |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Reproduction in Domestic Animals volume 47, issue s1, page 27-30 ISSN 0936-6768 1439-0531 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1439-0531.2011.01962.x |
container_title |
Reproduction in Domestic Animals |
container_volume |
47 |
container_issue |
s1 |
container_start_page |
27 |
op_container_end_page |
30 |
_version_ |
1800749755626684416 |