Characterization of peptides related to neuropeptide tyrosine and peptide tyrosine‐tyrosine from the brain and gastrointestinal tract of teleost fish
Neuropeptide Y was isolated from the brain of the Atlantic cod, Gadus morhua and its primary structure established as Tyr‐Pro‐Ile*‐Lys‐Pro‐Glu*‐Asn‐Pro‐Gly‐Glu10‐Asp‐Ala‐Pro‐Ala‐Ala‐Asp*‐Glu*‐Leu*‐Ala‐Lys*‐Tyr20‐Tyr‐Ser‐Ala‐Leu‐Arg‐His‐Tyr‐Ile‐Asn‐Leu30‐Ile‐Thr‐Arg‐Gln‐Arg‐Tyr‐CONH 2 . Residues deno...
Published in: | European Journal of Biochemistry |
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Online Access: | http://dx.doi.org/10.1111/j.1432-1033.1992.tb17435.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1432-1033.1992.tb17435.x https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1432-1033.1992.tb17435.x |
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crwiley:10.1111/j.1432-1033.1992.tb17435.x 2024-06-02T08:03:13+00:00 Characterization of peptides related to neuropeptide tyrosine and peptide tyrosine‐tyrosine from the brain and gastrointestinal tract of teleost fish JENSEN, Jörgen CONLON, J. Michael 1992 http://dx.doi.org/10.1111/j.1432-1033.1992.tb17435.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1432-1033.1992.tb17435.x https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1432-1033.1992.tb17435.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor European Journal of Biochemistry volume 210, issue 2, page 405-410 ISSN 0014-2956 1432-1033 journal-article 1992 crwiley https://doi.org/10.1111/j.1432-1033.1992.tb17435.x 2024-05-03T11:10:26Z Neuropeptide Y was isolated from the brain of the Atlantic cod, Gadus morhua and its primary structure established as Tyr‐Pro‐Ile*‐Lys‐Pro‐Glu*‐Asn‐Pro‐Gly‐Glu10‐Asp‐Ala‐Pro‐Ala‐Ala‐Asp*‐Glu*‐Leu*‐Ala‐Lys*‐Tyr20‐Tyr‐Ser‐Ala‐Leu‐Arg‐His‐Tyr‐Ile‐Asn‐Leu30‐Ile‐Thr‐Arg‐Gln‐Arg‐Tyr‐CONH 2 . Residues denoted by an asterisk are different from the corresponding sequence of human neuropeptide Y. A structurally similar peptide was isolated from the brain of the trout, Oncorhynchus mykiss . Trout neuropeptide Y contains four substitutions (Ile3→Val, Ala14→Thr, Asp15→Glu and Ser22→Thr) compared with cod neuropeptide Y. A second peptide of the neuropeptide Y family was identified in the trout brain and this component was structurally similar to peptide tyrosine‐tyrosine previously isolated from frog intestine (six amino acid substitutions) and identical to a peptide isolated from the pancreas of the closely related species, Oncorhynchus kisutch (Coho salmon). Peptide tyrosine‐tyrosine, with the same primary structure as the brain peptide, was also isolated from an extract of the trout stomach. The data indicate that a peptide analogous to mammalian neuropeptide Y is present in the brain of teleost fish and a peptide analogous to mammalian peptide tyrosine‐tyrosine is present in brain, gastrointestinal tissue and pancreas. We speculate, therefore, that the putative gene duplication that led to pancreatic polypeptide in the higher vertebrates took place after the time of divergence of fish and tetrapods. Article in Journal/Newspaper atlantic cod Gadus morhua Wiley Online Library European Journal of Biochemistry 210 2 405 410 |
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Wiley Online Library |
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language |
English |
description |
Neuropeptide Y was isolated from the brain of the Atlantic cod, Gadus morhua and its primary structure established as Tyr‐Pro‐Ile*‐Lys‐Pro‐Glu*‐Asn‐Pro‐Gly‐Glu10‐Asp‐Ala‐Pro‐Ala‐Ala‐Asp*‐Glu*‐Leu*‐Ala‐Lys*‐Tyr20‐Tyr‐Ser‐Ala‐Leu‐Arg‐His‐Tyr‐Ile‐Asn‐Leu30‐Ile‐Thr‐Arg‐Gln‐Arg‐Tyr‐CONH 2 . Residues denoted by an asterisk are different from the corresponding sequence of human neuropeptide Y. A structurally similar peptide was isolated from the brain of the trout, Oncorhynchus mykiss . Trout neuropeptide Y contains four substitutions (Ile3→Val, Ala14→Thr, Asp15→Glu and Ser22→Thr) compared with cod neuropeptide Y. A second peptide of the neuropeptide Y family was identified in the trout brain and this component was structurally similar to peptide tyrosine‐tyrosine previously isolated from frog intestine (six amino acid substitutions) and identical to a peptide isolated from the pancreas of the closely related species, Oncorhynchus kisutch (Coho salmon). Peptide tyrosine‐tyrosine, with the same primary structure as the brain peptide, was also isolated from an extract of the trout stomach. The data indicate that a peptide analogous to mammalian neuropeptide Y is present in the brain of teleost fish and a peptide analogous to mammalian peptide tyrosine‐tyrosine is present in brain, gastrointestinal tissue and pancreas. We speculate, therefore, that the putative gene duplication that led to pancreatic polypeptide in the higher vertebrates took place after the time of divergence of fish and tetrapods. |
format |
Article in Journal/Newspaper |
author |
JENSEN, Jörgen CONLON, J. Michael |
spellingShingle |
JENSEN, Jörgen CONLON, J. Michael Characterization of peptides related to neuropeptide tyrosine and peptide tyrosine‐tyrosine from the brain and gastrointestinal tract of teleost fish |
author_facet |
JENSEN, Jörgen CONLON, J. Michael |
author_sort |
JENSEN, Jörgen |
title |
Characterization of peptides related to neuropeptide tyrosine and peptide tyrosine‐tyrosine from the brain and gastrointestinal tract of teleost fish |
title_short |
Characterization of peptides related to neuropeptide tyrosine and peptide tyrosine‐tyrosine from the brain and gastrointestinal tract of teleost fish |
title_full |
Characterization of peptides related to neuropeptide tyrosine and peptide tyrosine‐tyrosine from the brain and gastrointestinal tract of teleost fish |
title_fullStr |
Characterization of peptides related to neuropeptide tyrosine and peptide tyrosine‐tyrosine from the brain and gastrointestinal tract of teleost fish |
title_full_unstemmed |
Characterization of peptides related to neuropeptide tyrosine and peptide tyrosine‐tyrosine from the brain and gastrointestinal tract of teleost fish |
title_sort |
characterization of peptides related to neuropeptide tyrosine and peptide tyrosine‐tyrosine from the brain and gastrointestinal tract of teleost fish |
publisher |
Wiley |
publishDate |
1992 |
url |
http://dx.doi.org/10.1111/j.1432-1033.1992.tb17435.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1432-1033.1992.tb17435.x https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1432-1033.1992.tb17435.x |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
European Journal of Biochemistry volume 210, issue 2, page 405-410 ISSN 0014-2956 1432-1033 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1432-1033.1992.tb17435.x |
container_title |
European Journal of Biochemistry |
container_volume |
210 |
container_issue |
2 |
container_start_page |
405 |
op_container_end_page |
410 |
_version_ |
1800747692872171520 |