HLA antigens in Tlingit Indians with rheumatoid arthritis
Abstract: HLA‐DR4 has been described in association with rheumatoid arthritis (RA) in multiple populations. We have studied HLA antigens in Alaskan Tlingit Indians. HLA‐DR4 was decreased in the RA group (n = 32) compared with controls (n = 62) (6% vs 21% p=0.07). The predominant DR4 allele observed...
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crwiley:10.1111/j.1399-0039.1992.tb01960.x 2024-06-02T08:15:16+00:00 HLA antigens in Tlingit Indians with rheumatoid arthritis Nelson, J. Lee Boyer, Georgiana Templin, David Lanier, Anne Barrington, Robert Nisperos, Brenda Smith, Anajane Mickelson, Eric Hansen, John A. 1992 http://dx.doi.org/10.1111/j.1399-0039.1992.tb01960.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1992.tb01960.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1992.tb01960.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Tissue Antigens volume 40, issue 2, page 57-63 ISSN 0001-2815 1399-0039 journal-article 1992 crwiley https://doi.org/10.1111/j.1399-0039.1992.tb01960.x 2024-05-03T10:58:59Z Abstract: HLA‐DR4 has been described in association with rheumatoid arthritis (RA) in multiple populations. We have studied HLA antigens in Alaskan Tlingit Indians. HLA‐DR4 was decreased in the RA group (n = 32) compared with controls (n = 62) (6% vs 21% p=0.07). The predominant DR4 allele observed was DRB1*0403 (Dw13.1). The most striking observation in these studies was a marked predominance of the DRB1*1402 allele encoding Dw16 (DRw14). This allele was present in 91% of RA cases, but was also highly prevalent in controls (80%, OR = 2.4 p = 0.20). DRB1*1402 only was observed in 47% of cases and 31% of controls. The DRB3*0101 (DRw52), and the DQA*0501 and DQB*0301 alleles encoding a subset of DQw3 were associated with DRB1*1402 in cases and in controls. HLA‐Bw62 was increased in RA cases (28%) compared with controls (8%) (OR = 4.5, p = 0.01, corrected p = ns). Article in Journal/Newspaper tlingit Wiley Online Library Tissue Antigens 40 2 57 63 |
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Wiley Online Library |
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English |
description |
Abstract: HLA‐DR4 has been described in association with rheumatoid arthritis (RA) in multiple populations. We have studied HLA antigens in Alaskan Tlingit Indians. HLA‐DR4 was decreased in the RA group (n = 32) compared with controls (n = 62) (6% vs 21% p=0.07). The predominant DR4 allele observed was DRB1*0403 (Dw13.1). The most striking observation in these studies was a marked predominance of the DRB1*1402 allele encoding Dw16 (DRw14). This allele was present in 91% of RA cases, but was also highly prevalent in controls (80%, OR = 2.4 p = 0.20). DRB1*1402 only was observed in 47% of cases and 31% of controls. The DRB3*0101 (DRw52), and the DQA*0501 and DQB*0301 alleles encoding a subset of DQw3 were associated with DRB1*1402 in cases and in controls. HLA‐Bw62 was increased in RA cases (28%) compared with controls (8%) (OR = 4.5, p = 0.01, corrected p = ns). |
format |
Article in Journal/Newspaper |
author |
Nelson, J. Lee Boyer, Georgiana Templin, David Lanier, Anne Barrington, Robert Nisperos, Brenda Smith, Anajane Mickelson, Eric Hansen, John A. |
spellingShingle |
Nelson, J. Lee Boyer, Georgiana Templin, David Lanier, Anne Barrington, Robert Nisperos, Brenda Smith, Anajane Mickelson, Eric Hansen, John A. HLA antigens in Tlingit Indians with rheumatoid arthritis |
author_facet |
Nelson, J. Lee Boyer, Georgiana Templin, David Lanier, Anne Barrington, Robert Nisperos, Brenda Smith, Anajane Mickelson, Eric Hansen, John A. |
author_sort |
Nelson, J. Lee |
title |
HLA antigens in Tlingit Indians with rheumatoid arthritis |
title_short |
HLA antigens in Tlingit Indians with rheumatoid arthritis |
title_full |
HLA antigens in Tlingit Indians with rheumatoid arthritis |
title_fullStr |
HLA antigens in Tlingit Indians with rheumatoid arthritis |
title_full_unstemmed |
HLA antigens in Tlingit Indians with rheumatoid arthritis |
title_sort |
hla antigens in tlingit indians with rheumatoid arthritis |
publisher |
Wiley |
publishDate |
1992 |
url |
http://dx.doi.org/10.1111/j.1399-0039.1992.tb01960.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1992.tb01960.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1992.tb01960.x |
genre |
tlingit |
genre_facet |
tlingit |
op_source |
Tissue Antigens volume 40, issue 2, page 57-63 ISSN 0001-2815 1399-0039 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1399-0039.1992.tb01960.x |
container_title |
Tissue Antigens |
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40 |
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2 |
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57 |
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63 |
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1800739381782249472 |